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The Thalamic reticular nucleus (TRN) provides major inhibitory inputs to the thalamus and plays important roles in sensory gating, attention selection and sleep rhythms. Many of the risk genes for ASD, schizophrenia and ADHD are highly expressed in the TRN, raising the possibility that TRN may be a circuit converging point for some of the overlapping behavioral abnormalities in these disorders. Using TRN-specific genetic deletions in mice, we demonstrate the critical roles of TRN dysfunction in attention deficit, hyperactivity and sleep disruption, commonly observed in neurodevelopmental disorders including ASD.

Department:  Neurosciences Institute

Contact: Roula J. El-Asmar | 6504501508 | roula@stanford.edu

Presenter(s):

• Guoping Feng Director Brain & Cognitive Sciences, MIT

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