Bio-X Frontiers in Interdisciplinary Biosciences Seminar, "Molecular Mechanisms in the Assembly of a Presynaptic Inhibitory Microcircuit"

Apr 09, 2015 (Thu) | 12:00 PM -1:05 PM
James H. Clark Center, 318 Campus Drive, Seminar Room S360 : Stanford, CA

Lunch to be served at 12:00PM; seminar begins at 12:15PM. Abstract: The regulation of information flow by local inhibitory microcircuits has a fundamental role in animal behavior. In the mammalian spinal cord GABAergic inhibitory interneurons serve key functions in sensory-motor transformation. One class termed GABApre neurons forms axo-axonic synapses with the terminals of proprioceptive sensory afferents and exerts an inhibitory constraint on sensory processing. We are using the GABApre interneuron circuitry to understand: how distinct neuronal populations are generated; how these distinct neuronal populations recognize and choose their correct synaptic partners from among different available targets; and how postsynaptic signals induce the differentiation of presynaptic terminals.

Department:  BioX

Contact: Christina Huber | 650-725-7472 | chuber@stanford.edu

Presenter(s):

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