Joshua Akey, "Characteristics of functional genomic variation in yeast and humans"
May 12, 2014 (Mon) | 4:00 PM -6:00 PM
393 Serra Mall, Herrin T-175 : Stanford, CA
My laboratory is broadly interested in leveraging patterns of genetic variation within and between species to make inferences about population history and the architecture of high-dimensional molecular phenotypes in a variety of organisms. I will discuss two ongoing areas of interest in the lab. First, I will describe experiments in yeast to dissect the genetics of heritable variation in functional genomics phenotypes such as mRNA decay rates and chromatin structure. Second, I will discuss patterns of putatively functional coding and non-coding variation in humans gleaned from massively large sequencing projects. In addition, I will show how archaic admixture between humans and Neandertals has contributed to patterns of adaptive and deleterious variation segregating in contemporary populations.
Contact: Maria Magana-Lopez | 650-723-2413 | firstname.lastname@example.org