Frank Pugh, "Genomic mechanisms of chromatin organization and transcription initiation"
Nov 18, 2013 (Mon) | 4:00 PM -6:00 PM
393 Serra Mall, Herrin T-175 : Stanford, CA
Abstract: From yeast to humans, transcription initiates across the genome in nucleosome-free regions. RNA polymerase II then proceeds to transcribe both coding and noncoding genes that are encased within a nucleosome array. Dr. Pugh’s lecture will describe his lab’s development and application of the ChIP-exo assay to locate at near-single bp resolution where transcription and chromatin regulators reside across yeast and human genomes. The level of detail provided offers a novel structural glimpse of these protein/DNA complexes on a genomic scale. In addition, they suggest mechanisms by which the transcription machinery assembles at coding and noncoding genes and how they engage chromatin. The lecture will also touch on how remodeling factors use the same nucleosome-free promoter regions to organize nucleosomal arrays.
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