Education and Training
Assessing the Endometrial Environment in Recurrent Pregnancy Loss and Unexplained Infertility
The purpose of this study is to determine if patients with recurrent pregnancy loss or unexplained infertility have an altered uterine gene expression or uterine microbiome (micro-organism composition) during the window of embryo implantation. Furthermore we would like to assess for women with an abnormal uterine gene expression whether vaginal progesterone medication improves or alters gene expression and for women with an abnormal microbiome whether antibiotic treatment followed by probiotic treatment normalizes the microbiome.
Stanford is currently not accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- diagnostic test: Uterine ERA and microbiome testing
- drug: Oral antibiotics and vaginal probiotics
Eligibility
Inclusion/Exclusion Criteria:
1. Recurrent Pregnancy Loss
Inclusion:
- Age 18-45
- 3 or more SABs including biochemical pregnancies OR 2 or more SABs if one is
documented to be euploid
Exclusion:
- irregular menstrual cycles
- Submucosal fibroid >3cm
- Stage 3-4 endometriosis
- BMI >40
- IUD within the last 3 months
2. Unexplained infertility Patients
Inclusion:
- TTC x >= 1 year
- At least one SA with TMS >10 mil within last 2 years
- At least one patent fallopian tube documented by HSG or SHG
- Cycle length 25-35 days
Exclusion:
- Irregular menstrual cycles
- Submucosal fibroid >3cm
- Stage 3-4 endometriosis
- BMI >40
- IUD within the last 3 months
- Less then 2 SABs including biochemical pregnancies
3. Healthy control patients
Inclusion:
- Patients who present for fertility preservation, sex selection, same sex couples
needing fertility care, preconception counseling
- 1 or more live births
Exclusion:
- Irregular menstrual cycles
- Submucosal fibroid >3cm
- Stage 3-4 endometriosis
- BMI >40
- IUD within the last 3 months
- Less then 2 SABs including biochemical pregnancies
- No history of RPL or infertility
Ages Eligible for Study
18 Years - 45 Years
Genders Eligible for Study
Female
Not currently accepting new patients for this trial
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Sara J Churchill, MD
617-513-4997
Not Recruiting