Weight Loss Diet Study: Low Carb vs Low Fat
The traditional weight loss diet recommended by health professionals has been a low-fat, high-carbohydrate, calorie restricted diet. This recommendation has been challenged by a number of alternative dietary strategies, particularly low-carbohydrate diets. In several recent weight loss studies insulin resistant adults had more success with low- vs. high-carbohydrate diets, in contrast to insulin sensitive adults who had either more success or comparable success with the low-fat diets. The investigators enrolled 61 people with a wide range of insulin sensitivity/resistance. After determining their insulin resistance status, the investigators will split them in the middle and randomly assign them to one of four groups for six months: (1) Low-Carbohydrate/Insulin Resistant (LC/IR); (2) Low-Carbohydrate/Insulin Sensitive (LC/IS); (3) Low-Fat/Insulin Resistant (LF/IR); and (4) Low-Fat/Insulin Sensitive (LF/IS) (15 people/group). After 6 months the participants will switch diet for the following 6 months, i.e. those randomized to the Low-Carbohydrate diet will switch to the Low-Fat diet and vice-versa. The primary outcome of this study is to determine whether weight loss success can be increased if one follows the dietary approach appropriately matched to their insulin resistance status. Secondary outcomes include fasting insulin, glucose, lipids, and fatty acid composition.
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Stanford is currently not accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- behavioral: Low-Carbohydrate Diet
- behavioral: Low-Fat Diet
Eligibility
Inclusion Criteria:
- Age: > or = 18 years of age
- Women: Pre-menopausal (self-report) and <50 years of age
- Men: <50 years of age
- Race/Ethnicity: All
- BMI (body mass index): 28-40 kg/m2 (need to lose >10% body weight to achieve healthy
BMI)
- Body weight stable for the last two months, and not actively on a weight loss plan
- No plans to move from the area over the next 14 months
- Available and able to participate in the evaluations and intervention for the study
period
- Willing to accept random assignment
- To enhance study generalizability, people on medications not noted below as specific
exclusions can participate if they have been stable on such medications for at least
three months
- Ability and willingness to give written informed consent
- No known active psychiatric illness
Exclusion Criteria:
- Pregnant, lactating, within 6 months post-partum, or planning to become pregnant in
the next 12 months; no menstruation for the previous 12 months
- Diabetes (type 1 and 2) or history of gestational diabetes or on hypoglycemic
medications for any other indication
- Prevalent diseases: Malabsorption, renal or liver disease, active neoplasms, recent
myocardial infarction, hypertension (except for those stable on hypertensive
medications) (<6 months) (patient self-report and, if available, review of labs from
primary care provider)
- Smokers (because of effect on weight and lipids)
- History of serious arrhythmias, or cerebrovascular disease
- Uncontrolled hyper- or hypothyroidism (TSH not within normal limits)
- Medications: Lipid lowering, diabetes medications, and those known to affect
weight/energy expenditure
- Excessive alcohol intake (self-reported, >3 drinks/day)
Ages Eligible for Study
18 Years - 50 Years
Genders Eligible for Study
All
Not currently accepting new patients for this trial
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Antonella Dewell
6507368577
Not Recruiting
Our research team includes physicians, residents, medical students, research assistants, and volunteers. Our research topics include medical imaging, device validation, mobile application development, and pharmaceutical trials.
Some of the Neuro-Opthalmic concerns we investigate include Multiple Sclerosis, Optic Neuritis, IIH, and ICP.