Publications

Lab Publications

Journal Articles

[18F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease.

James ML, Belichenko NP, Shuhendler AJ, Hoehne A, Andrews LE, Condon C, Nguyen TV, Reiser V, Jones P, Trigg W, Rao J, Gambhir SS, Longo FM.
Theranostics. 2017 Mar 24;7(6):1422-1436. doi: 10.7150/thno.17666. eCollection 2017.
PMID: 28529627

Neurotrophin receptor signaling as a therapeutic target for Huntington's Disease.

Simmons, DA, Longo FM, Massa SM. CNS Neurol Disord Drug Targets. 2016
PMID:27823570

A small molecule p75NTR ligand normalizes signaling and reduces Huntington’s Disease phenotypes in R6/2 and BACHD mice.

Danielle A. Simmons, Nadia P. Belichenko, Ellen C. Ford, Sarah Semaan, Marie Monbureau, Sruti Aiyaswamy, Cameron M. Holman, Christina Condon, Mehrdad Shamloo, Stephen M. Massa and Frank M. Longo.
Hum. Mol. Genet. 2016

A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth

Tao Yang, Stephen M. Massa, Kevin C. Tran, Danielle A. Simmons, Jayakumar Rajadas, Anne Y. Zeng, Taichang Jang, Sara Carsanaro, Frank M. Longo
Neuropharmacology. 2016 Nov; 110(A):343-361
PMID:27334657

A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM.
PLoS One. 2014 Aug 25;9(8):e102136. doi: 10.1371/journal.pone.0102136. eCollection 2014.
PMID:25153701

Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.

Nguyen TV, Shen L, Vander Griend L, Quach LN, Belichenko NP, Saw N, Yang T, Shamloo M, Wyss-Coray T, Massa SM, Longo FM.
J Alzheimers Dis. 2014;42(2):459-83. doi: 10.3233/JAD-140036.
PMID:24898660

A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.

Simmons DA, Belichenko NP, Yang T, Condon C, Monbureau M, Shamloo M, Jing D, Massa SM, Longo FM.
J Neurosci. 2013 Nov 27;33(48):18712-27. doi: 10.1523/JNEUROSCI.1310-13.2013. Erratum in: J Neurosci. 2014 Jan 29;34(5):2012.
PMID:24285878

Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.

Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM.
Neurobiol Aging. 2013 Aug;34(8):2052-63. doi: 10.1016/j.neurobiolaging.2013.02.015. Epub 2013 Mar 29.
PMID:23545424

Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.

Longo FM, Massa SM.
Nat Rev Drug Discov. 2013 Jul;12(7):507-25. Review.
PMID:23977697

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.

Massa SM, Yang T, Xie Y, Shi J, Bilgen M, Joyce JN, Nehama D, Rajadas J, Longo FM.
J Clin Invest. 2010 May;120(5):1774-85. doi: 10.1172/JCI41356. Epub 2010 Apr 19.
PMID:20407211

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.

Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM.
J Neurosci. 2009 Aug 26;29(34):10627-37. doi: 10.1523/JNEUROSCI.0620-09.2009.
PMID:19710315

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.

Yang T, Knowles JK, Lu Q, Zhang H, Arancio O, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller GG, Xie Y, Massa SM, Longo FM.
PLoS One. 2008;3(11):e3604. doi: 10.1371/journal.pone.0003604. Epub 2008 Nov 3.
PMID:18978948

Small molecule modulation of p75 neurotrophin receptor functions.

Longo FM, Massa SM.
CNS Neurol Disord Drug Targets. 2008 Feb;7(1):63-70. Review.
PMID:18289033

Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms.

Longo FM, Yang T, Knowles JK, Xie Y, Moore LA, Massa SM.
Curr Alzheimer Res. 2007 Dec;4(5):503-6. Review.
PMID:18220511

LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways.

Yang T, Massa SM, Longo FM.
J Neurobiol. 2006

Book Chapters

Simmons, DA, Yang, T., Massa, S.M. and Longo, F.M. (2016) Wolfe, M.S. (ed.), In Developing Therapeutics for Alzheimer's Disease: Progress and Challenges. Elsevier Inc., Cambridge, MA, USA, in press., pp. 437-449.

Collaborative Publications

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity.

Czirr E, Castello NA, Mosher KI, Castellano JM, Hinkson IV, Lucin KM, Baeza-Raja B, Ryu JK, Li L, Farina SN, Belichenko NP, Longo FM, Akassoglou K, Britschgi M, Cirrito JR, Wyss-Coray T.
J Exp Med. 2017 Apr 3;214(4):1081-1092. doi: 10.1084/jem.20162011. Epub 2017 Mar 15.
PMID: 28298456

The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice that Is Reversed by Tropomyosin Receptor Kinase B Activation.

Warnault V, Darcq E, Morisot N, Phamluong K, Wilbrecht L, Massa SM, Longo FM, Ron D.
Biol Psychiatry. 2015 Jun 12. pii: S0006-3223(15)00481-3. doi: 10.1016/j.biopsych.2015.06.007.
PMID: 26204799

A strategy for analyzing bond strength and interaction kinetics between Pleckstrin homology domains and PI(4,5)P2 phospholipids using force distance spectroscopy and surface plasmon resonance.

Malkovskiy AV, Wagh DA, Longo FM, Rajadas J.
Analyst. 2015 Jun 15;140(13):4558-65. doi: 10.1039/c5an00498e.
PMID:26040325

B-lymphocyte-mediated delayed cognitive impairment following stroke.

Doyle KP, Quach LN, Solé M, Axtell RC, Nguyen TV, Soler-Llavina GJ, Jurado S, Han J, Steinman L, Longo FM, Schneider JA, Malenka RC, Buckwalter MS.
J Neurosci. 2015 Feb 4;35(5):2133-45. doi: 10.1523/JNEUROSCI.4098-14.2015.
PMID:25653369

PET imaging of translocator protein (18 kDa) in a mouse model of Alzheimer's disease using N-(2,5-dimethoxybenzyl)-2-18F-fluoro-N-(2-phenoxyphenyl)acetamide.

James ML, Belichenko NP, Nguyen TV, Andrews LE, Ding Z, Liu H, Bodapati D, Arksey N, Shen B, Cheng Z, Wyss-Coray T, Gambhir SS, Longo FM, Chin FT.
J Nucl Med. 2015 Feb;56(2):311-6. doi: 10.2967/jnumed.114.141648. Epub 2015 Jan 22.
PMID:25613536

Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury.

Xu B, Park D, Ohtake Y, Li H, Hayat U, Liu J, Selzer ME, Longo FM, Li S.
Neurobiol Dis. 2015 Jan;73:36-48. doi: 10.1016/j.nbd.2014.08.030. Epub 2014 Sep 8.
PMID:25220840

Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75 NTR.

Friesland A, Weng Z, Duenas M, Massa SM, Longo FM, Lu Q.
Neurotoxicology. 2014 Dec;45:81-90. doi: 10.1016/j.neuro.2014.09.005. Epub 2014 Sep 30.
PMID:25277379

Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus.

Grabenstatter HL, Carlsen J, Raol YH, Yang T, Hund D, Cruz Del Angel Y, White AM, Gonzalez MI, Longo FM, Russek SJ, Brooks-Kayal AR.
J Neurosci Res. 2014 Oct;92(10):1307-18. doi: 10.1002/jnr.23402. Epub 2014 May 7.
PMID:24801281

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.

Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo FM, Wyss-Coray T.
Nat Med. 2014 Jun;20(6):659-63. doi: 10.1038/nm.3569. Epub 2014 May 4.
PMID:24793238

A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury.

Shi J, Longo FM, Massa SM.
Stem Cells. 2013 Nov;31(11):2561-74. doi: 10.1002/stem.1516.
PMID:23940017

Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury.

Tep C, Lim TH, Ko PO, Getahun S, Ryu JC, Goettl VM, Massa SM, Basso M, Longo FM, Yoon SO.
J Neurosci. 2013 Jan 9;33(2):397-410. doi: 10.1523/JNEUROSCI.0399-12.2013. Erratum in: J Neurosci. 2014 Jan 29;34(5):2012.
PMID:23303920

Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke.

Han J, Pollak J, Yang T, Siddiqui MR, Doyle KP, Taravosh-Lahn K, Cekanaviciute E, Han A, Goodman JZ, Jones B, Jing D, Massa SM, Longo FM, Buckwalter MS.
Stroke. 2012 Jul;43(7):1918-24. doi: 10.1161/STROKEAHA.111.641878. Epub 2012 Apr 24.
PMID:22535263

Suppression of immunodeficiency virus-associated neural damage by the p75 neurotrophin receptor ligand, LM11A-31, in an in vitro feline model.

Meeker RB, Poulton W, Feng WH, Hudson L, Longo FM.
J Neuroimmune Pharmacol. 2012 Jun;7(2):388-400. doi: 10.1007/s11481-011-9325-0. Epub 2011 Dec 10.
PMID:22161560

Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function.

Faizi M, Bader PL, Saw N, Nguyen TV, Beraki S, Wyss-Coray T, Longo FM, Shamloo M.
Brain Behav. 2012 Mar;2(2):142-54. doi: 10.1002/brb3.41.
PMID:22574282

A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome.

Schmid DA, Yang T, Ogier M, Adams I, Mirakhur Y, Wang Q, Massa SM, Longo FM, Katz DM.
J Neurosci. 2012 Feb 1;32(5):1803-10. doi: 10.1523/JNEUROSCI.0865-11.2012. Erratum in: J Neurosci. 2014 Jan 29;34(5):2012.
PMID:22302819

The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis.

Bernabeu RO, Longo FM.
BMC Neurosci. 2010 Oct 20;11:136. doi: 10.1186/1471-2202-11-136.
PMID:20961458