WELCOME TO THE YE LAB
Otto H. Warburg, 1883-1970.
One hundred years ago, Otto H. Warburg identified the metabolic hallmark of cancer, now known as the Warburg effect. This phenomenon observes that tumor cells consume glucose at an elevated rate and produce significant amounts of lactate. It posed a challenging question: why would tumor cells rely on the Warburg effect when the production and excretion of lactate seemed like an inefficient use of the carbon backbone and energy essential for proliferation? In one of his seminal reviews, Warburg suggested that the Warburg effect stemmed from respiratory injury, leading to cell dedifferentiation. Not only did he recognize that inhibiting respiration resulted in metabolic reprogramming, he also astutely proposed a link between metabolic shifts and cell dedifferentiation. However, the precise mechanism was elusive due to the then-limited understanding of the interplay between metabolism and epigenetic regulation.
Our laboratory is dedicated to pursuing two primary objectives:
(1) Elucidating the manner in which the Warburg effect/metabolic reprogramming is triggered, subsequently remodeling the epigenetic landscape and disrupt differentiation.
(2) Develop metabolic therapy that can reverse the Warburg effect and reactivate differentiation, effectively reverting cancer cells back to normal cells.