From Precision Biology to Precision Medicine in Pulmonary Hypertension:
Revolutionizing Healthcare through Revolutionary Science

Friday, May 18, 2018 – Sheraton Palo Alto

Session 1: Precision Biology

Moderators: Vinicio de Jesus Perez, MD & Andrew Sweatt, MD

7:30am – 8:15am 

8:15 – 8:20  
Welcome from the Wall Center
Marlene Rabinovitch, MD
Stanford University

8:20 – 9:00  
Precision Biology and Precision Medicine: A Primer
Joseph Loscalzo, MD, PhD
Harvard University

Single Cell ‘Omics 

9:00 – 9:30 (No Live Stream)
Molecular Cell Atlas of the Human Lung
Kyle Travaglini and Astrid Gillich, PhD
Stanford University

9:30 – 10:00
Transcriptomic Profiling of the Lung
Tushar Desai, MD, MPH
Stanford University

10:00– 10:30 
Spatial Proteomics and the Single Cell
Emma Lundberg, PhD
Stanford University

10:30 – 11:00


Novel Preclinical Models of Disease

11:00 – 11:15 (No Live Stream)
Single Cell Analysis of the Pulmonary Vasculature
Ross Metzger, PhD
Stanford University

11:15 – 11:30  
Using Lineage Tracing and RNA Seq to Understand Neointima Formation in Pulmonary Vascular Disease
Maya Kumar, PhD
Stanford University

11:30 – 11:45 (No Live Stream)
Single Cell RNA Seq to Dissect Pericyte Fate in Mice
Ke Yuan, PhD
Stanford University

11:45 – 12:00  
High Throughput Drug Screening of iPSC Derived Vascular Cells to Reverse PAH Phenotype? 
Mingxia Gu, MD, MPH
Stanford University

12:00 – 1:00

Session 2: Precision Medicine

Moderators: Edda Spiekerkoetter, MD & Rachel Hopper, MD

1:00 – 1:45
What Complete Genome Sequencing Tells us About Genetic Causes of PAH in the UK: Results from the BRIDGE Study
Nick Morrell, MD
Cambridge University, UK


‘Omics in Pulmonary Vascular Medicine

1:45 – 2:15  
Application of Metabolomics to Identify Unique Clinical Phenotypes in the PAH Population
Christopher Rhodes, PhD
Imperial College, UK

2:15 – 2:45
Immune Phenotyping of PAH
Andrew Sweatt, MD
Stanford University

2:45 – 3:00  
Update from the Ongoing NIH PVDOMICs Study: Can the Combination of Multiple ‘Omics Strategies Help in the Risk Stratification of PAH Patients?
Jane Leopold, MD
Brigham and Women's Hospital, Boston

3:00– 3:15 
Targeting the BMPR2 Pathways as an Example for Precision Medicine
Edda Spiekerkoetter, MD
Stanford University

3:15 – 3:30 

Learning from Other Disciplines to Improve Management of Individuals with PAH?

3:30 – 4:00
Bioengineering in PH: Computational Modeling of Patient-Specific Hemodynamics to Predict Clinical Outcomes
Alison Marsden, PhD
Stanford University

4:00 – 4:30  
Obtaining Unbiased Data from Big Data Analysis: Do We “Lump” or Do We “Split”?
Purvesh Khatri, PhD
Stanford University

4:30 – 5:00  
Precision Medicine for All?  Addressing Health Disparities and Patient Privacy
Evan Brittain, MD
Vanderbilt University

5:00 – 6:00
Panel Discussion:
Lena Bolivar | Former Patient
Jeffrey Feinstein, MD, MPH | Stanford University
Derek Solum, PhD | United Therapeutics
Gayathri Swaminath, PhD | Merck
Roham Zamanian, MD | Stanford University

6:00 – 6:30