The Leeper laboratory studies the vascular biology of atherosclerosis and aneurysm disease. We are interested in the molecular mechanisms that mediate vascular disease, and developing new translational therapies directed against them. Our group uses a combination of hypothesis-free genetic approaches, favoring the concept that insights generated in this manner are likely to have relevance to human disease. Currently, our major focus is on a process known as ‘programmed cell removal’, or ‘efferocytosis’ (Latin: to carry the dead to the grave’). We seek to determine why diseased cells accumulate in the atherosclerotic plaque, and how to harness the power of the immune system as a means to reactivate their removal and stabilize the vulnerable lesion. Our group pursues the goal of true ‘bench-to-bedside’ translation, bringing together interdisciplinary experts spanning the fields of genomics, molecular biology, translational vascular biology, and clinical Vascular Medicine. Ultimately, we seek to train the next generation of investigators and physician-scientists who will develop a platform of new therapies directed against atherosclerosis, which is now the leading killer worldwide.
"Good vascular health is the key to longevity"
Watch Elsie Ross, MD Vascular Surgeon and Eri Fukaya, MD Vascular Medicine Specialist, discuss the importance of vascular health and how to protect your vascular system.
News, Events, and Team Milestones
Publication in Nature Nanotechnology
Trojan horse nanoparticles deliver anti-atherosclerotic therapy specifically to the diseased blood vessel
Society for Vascular Medicine Young Investigator Award
Congratulation to Leeper Lab Postdoctoral fellow Lingfeng Luo for being awarded the Society for Vascular Medicine (SVM) Young Investigator Award, for his abstract "Efficient suppression of vascular smooth muscle cell proliferation and intimal hyperplasia by targeting phosphodiesterase 10A". He will be presenting his research at the SVM 2021 Scientific Sessions on September 9-11, 2021.
2021 Hoeg Award
We are excited to announce that Dr. Nick Leeper, will be awarded the Jeffrey M. Hoeg Arteriosclerosis, Thrombosis, and Vascular Biology Award for Basic Science and Clinical Research. Dr. Leeper will receive his award during the Vascular Discovery: From Genes to Medicine Scientific Sessions 2021.
Leeper Lab Alumna off to Medical School
Congratulations to Leeper lab alumna, Jessie Dalman, on being accepted to the University of Michigan Medical School. Best wishes to Jessie as she embarks on this exciting new journey!