February 2020 Member Publications

59 CVI Member Publications for February

1.     The metabolic signature of T cells in rheumatoid arthritis. Weyand CM, Wu B, Goronzy JJ. Curr Opin Rheumatol. 2020 Mar;32(2):159-167. doi: 10.1097/BOR.0000000000000683. PMID: 31895885

2.     Multi-phase catheter-injectable hydrogel enables dual-stage protein-engineered cytokine release to mitigate adverse left ventricular remodeling following myocardial infarction in a small animal model and a large animal model. Steele AN, Paulsen MJ, Wang H, Stapleton LM, Lucian HJ, Eskandari A, Hironaka CE, Farry JM, Baker SW, Thakore AD, Jaatinen KJ, Tada Y, Hollander MJ, Williams KM, Seymour AJ, Totherow KP, Yu AC, Cochran JR, Appel EA, Woo YJ. Cytokine. 2020 Mar;127:154974. doi: 10.1016/j.cyto.2019.154974. Epub 2020 Jan 21. PMID: 31978642

3.     Comparison of Long-Term Adverse Outcomes in Patients With Atrial Fibrillation Having Ablation Versus Antiarrhythmic Medications. Freeman JV, Tabada GH, Reynolds K, Sung SH, Singer DE, Wang PJ, Liu TI, Gupta N, Hlatky MA, Go AS. Am J Cardiol. 2020 Feb 15;125(4):553-561. doi: 10.1016/j.amjcard.2019.11.004. Epub 2019 Nov 19. PMID:31843233

4.     Total Microfluidic chip for Multiplexed diagnostics (ToMMx). Ozen MO, Sridhar K, Ogut MG, Shanmugam A, Avadhani AS, Kobayashi Y, Wu JC, Haddad F, Demirci U. Biosens Bioelectron. 2020 Feb 15;150:111930. doi: 10.1016/j.bios.2019.111930. Epub 2019 Nov 28. PMID: 31929083

5.     Enantioselective Total Syntheses of Lyconadins A-E through a Palladium-Catalyzed Heck-Type Reaction. Zhang J, Yan Y, Hu R, Li T, Bai WJ, Yang Y. Angew Chem Int Ed Engl. 2020 Feb 10;59(7):2860-2866. doi: 10.1002/anie.201912948. Epub 2020 Jan 7. PMID: 31743549

6.     Exact inference for the random-effect model for meta-analyses with rare events. Gronsbell J, Hong C, Nie L, Lu Y, Tian L. Stat Med. 2020 Feb 10;39(3):252-264. doi: 10.1002/sim.8396. Epub 2019 Dec 9. PMID: 31820458

7.     The Hallmarks of Severe Pulmonary Arterial Hypertension: The Cancer Hypothesis - Ten years later. Cool CD, Kuebler WM, Bogaard HJ, Spiekerkoetter E, Nicolls MR, Voelkel NF. Am J Physiol Lung Cell Mol Physiol. 2020 Feb 5. doi: 10.1152/ajplung.00476.2019. [Epub ahead of print] PMID: 32023082

8.     Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway. Dubreuil MM, Morgens DW, Okumoto K, Honsho M, Contrepois K, Lee-McMullen B, Traber GM, Sood RS, Dixon SJ, Snyder MP, Fujiki Y, Bassik MC. Cell Rep. 2020 Feb 4;30(5):1417-1433.e7. doi: 10.1016/j.celrep.2020.01.013. PMID: 32023459

9.     Healthy Hearts via Live Videoconferencing: An Exercise and Diet Intervention in Pediatric Heart Transplant Recipients. Chen AC, Ramirez FD, Rosenthal DN, Couch SC, Berry S, Stauffer KJ, Brabender J, McDonald N, Lee D, Barkoff L, Nourse SE, Kazmucha J, Wang CJ, Olson I, Selamet Tierney ES. J Am Heart Assoc. 2020 Feb 4;9(3):e013816. doi: 10.1161/JAHA.119.013816. Epub 2020 Jan 24. PMID: 31973598

10.  Multiomic immune clockworks of pregnancy. Peterson LS, Stelzer IA, Tsai AS, Ghaemi MS, Han X, Ando K, Winn VD, Martinez NR, Contrepois K, Moufarrej MN, Quake S, Relman DA, Snyder MP, Shaw GM, Stevenson DK, Wong RJ, Arck P, Angst MS, Aghaeepour N, Gaudilliere B. Semin Immunopathol. 2020 Feb 4. doi: 10.1007/s00281-019-00772-1. [Epub ahead of print] Review. PMID: 32020337

11.  Carbon-coated FeCo nanoparticles as sensitive magnetic-particle-imaging tracers with photothermal and magnetothermal properties. Song G, Kenney M, Chen YS, Zheng X, Deng Y, Chen Z, Wang SX, Gambhir SSDai H, Rao J. Nat Biomed Eng. 2020 Feb 3. doi: 10.1038/s41551-019-0506-0. [Epub ahead of print] PMID: 32015409

12.  Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations.Curigliano G, Lenihan D, Fradley M, Ganatra S, Barac A, Blaes A, Herrmann J, Porter C, Lyon AR, Lancellotti P, Patel A, DeCara J, Mitchell J, Harrison E, Moslehi J, Witteles R, Calabro MG, Orecchia R, de Azambuja E, Zamorano JL, Krone R, Iakobishvili Z, Carver J, Armenian S, Ky B, Cardinale D, Cipolla CM, Dent S, Jordan K; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org. Ann Oncol. 2020 Feb;31(2):171-190. doi: 10.1016/j.annonc.2019.10.023. PMID: 31959335

13.  The Oldest Old: A National Analysis of Outcomes for Patients 90 Years or Older With Lung Cancer. Yang CJ, Brown AB, Deng JZ, Lui NS, Backhus LM, Shrager JB, D'Amico TA, Berry MF. Ann Thorac Surg. 2020 Feb;109(2):350-357. doi: 10.1016/j.athoracsur.2019.09.027. Epub 2019 Nov 19. PMID: 31757356

14.  Bridge to Transplant with Ventricular Assist Device Support in Pediatric Patients with Single Ventricle Heart Disease. Chen S, Rosenthal DN, Murray J, Dykes JC, Almond CS, Yarlagadda VVWright G, Navaratnam M, Reinhartz O, Maeda K. ASAIO J. 2020 Feb;66(2):205-211. doi: 10.1097/MAT.0000000000000983. PMID: 30864969

15.  Morphological, immunophenotypical and molecular features of hypermutation in colorectal carcinomas with mutations in DNA polymerase ε (POLE). Forgó E, Gomez AJ, Steiner D, Zehnder J, Longacre TA. Histopathology. 2020 Feb;76(3):366-374. doi: 10.1111/his.13984. Epub 2019 Dec 1. PMID: 31479159

16.  Maternal Vascular Health in Pregnancy and Postpartum After Assisted Reproduction. von Versen-Höynck F, Häckl S, Selamet Tierney ES, Conrad KP, Baker VL, Winn VD. Hypertension. 2020 Feb;75(2):549-560. doi: 10.1161/HYPERTENSIONAHA.119.13779. Epub 2019 Dec 16. PMID: 31838910

17.  Safety-Net Care for Maintenance Dialysis in the United States. Erickson KF, Shen JI, Zhao B, Winkelmayer WC, Chertow GM, Ho V, Bhattacharya J. J Am Soc Nephrol. 2020 Feb;31(2):424-433. doi: 10.1681/ASN.2019040417. Epub 2019 Dec 19. PMID: 31857351

18.  Bronchial Artery Embolization for Hemoptysis in Cystic Fibrosis Patients: A 17-Year Review. Martin LN, Higgins L, Mohabir P, Sze DY, Hofmann LV. J Vasc Interv Radiol. 2020 Feb;31(2):331-335. doi: 10.1016/j.jvir.2019.08.028. Epub 2019 Dec 30. PMID: 31899109

19.  Lower Extremity Venous Stent Placement: A Large Retrospective Single-Center Analysis. Mabud TS, Cohn DM, Arendt VA, Jeon GS, An X, Fu J, Souffrant AD, Sailer AM, Shah R, Wang D, Sze DY, Kuo WT, Rubin DL, Hofmann LV. J Vasc Interv Radiol. 2020 Feb;31(2):251-259.e2. doi: 10.1016/j.jvir.2019.06.011. Epub 2019 Sep 18. PMID: 31542273

20.  Deep Characterization of the Human Antibody Response to Natural Infection Using Longitudinal Immune Repertoire Sequencing. Mitsunaga EM, Snyder MP. Mol Cell Proteomics. 2020 Feb;19(2):278-293. doi: 10.1074/mcp.RA119.001633. Epub 2019 Nov 25. PMID: 31767621

21.  Pediatric waitlist and heart transplant outcomes in patients with syndromic anomalies. Wilkens SJ, Priest J, Kaufman BD, Barkoff L, Rosenthal DN, Hollander SA. Pediatr Transplant. 2020 Feb;24(1):e13643. doi: 10.1111/petr.13643. Epub 2019 Dec 31. PMID: 31891211

22.  Growth stunting in single ventricle patients after heart transplantation. Power A, Schultz L, Dennis K, Rizzuto S, Hollander AM, Rosenthal DN, Almond CS, Hollander SA. Pediatr Transplant. 2020 Feb;24(1):e13634. doi: 10.1111/petr.13634. Epub 2019 Dec 16. PMID: 31845499

23.  RNA Sequencing Analysis of Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Congenital Heart Disease Patients. Kitani T, Tian L, Zhang T, Itzhaki I, Zhang JZ, Ma N, Liu C, Rhee JW, Romfh A, Lui GK, Wu JC. Circ Res. 2020 Feb 19. doi: 10.1161/CIRCRESAHA.119.315653. [Epub ahead of print] No abstract available. PMID: 32070195

24.  Fitness for Richer, for Poorer. Kokkinos P, Myers J. Eur J Prev Cardiol. 2020 Feb 18:2047487320905024. doi: 10.1177/2047487320905024. [Epub ahead of print] No abstract available. PMID: 32070132

25.  Computed Tomographic Angiography-Based Fractional Flow Reserve Compared With Catheter-Based Dobutamine-Stress Diastolic Fractional Flow Reserve in Symptomatic Patients With a Myocardial Bridge and No Obstructive Coronary Artery Disease. Jubran A, Schnittger I, Tremmel J, Pargaonkar V, Rogers I, Becker HC, Yang S, Mastrodicasa D, Willemink M, Fleischmann DNieman K. Circ Cardiovasc Imaging. 2020 Feb;13(2):e009576. doi: 10.1161/CIRCIMAGING.119.009576. Epub 2020 Feb 11. No abstract available. PMID: 32069114

26.  Hypoperfusion Intensity Ratio Correlates With Angiographic Collaterals In Acute Ischemic Stroke With M1 Occlusion. Guenego A, Fahed R, Albers GW, Kuraitis G, Sussman ES, Martin BW, Marcellus DG, Olivot JM, Marks MP, Lansberg MG, Wintermark M, Heit JJ. Eur J Neurol. 2020 Feb 18. doi: 10.1111/ene.14181. [Epub ahead of print] PMID: 32068938

27.  Preparing Medical Imaging Data for Machine Learning. Willemink MJ, Koszek WA, Hardell C, Wu J, Fleischmann D, Harvey H, Folio LR, Summers RM, Rubin DL, Lungren MP. Radiology. 2020 Feb 18:192224. doi: 10.1148/radiol.2020192224. [Epub ahead of print] PMID: 32068507

28.  Cangrelor in clinical use. Feng KY, Mahaffey KW. Future Cardiol. 2020 Feb 18. doi: 10.2217/fca-2019-0095. [Epub ahead of print] PMID: 32067479

29.  True bipolar or extended bipolar left ventricular pacing is associated with better survival in cardiac resynchronization therapy patients. Kutyifa V, Jame S, Wang PJ, Musat D, Jones P, Wehrenberg S, Stein K. Pacing Clin Electrophysiol. 2020 Feb 18. doi: 10.1111/pace.13889. [Epub ahead of print] PMID: 32067233

30.  A single-parasite transcriptional atlas of Toxoplasma gondii reveals novel control of antigen expression. Xue Y, Theisen TC, Rastogi S, Ferrel A, Quake SR, Boothroyd JC. Elife. 2020 Feb 17;9. pii: e54129. doi: 10.7554/eLife.54129. [Epub ahead of print] PMID: 32065584

31.  Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau. Wilson EN, Swarovski MS, Linortner P, Shahid M, Zuckerman AJ, Wang Q, Channappa D, Minhas PS, Mhatre SD, Plowey ED, Quinn JF, Zabetian CP, Tian L, Longo FM, Cholerton B, Montine TJ, Poston KL, Andreasson KI. Brain. 2020 Feb 17. pii: awaa021. doi: 10.1093/brain/awaa021. [Epub ahead of print. PMID: 32065223

32.  On the empirical choice of the time window for restricted mean survival time. Tian L, Jin H, Uno H, Lu Y, Huang B, Anderson KM, Wei LJ. Biometrics. 2020 Feb 15. doi: 10.1111/biom.13237. [Epub ahead of print] PMID: 32061098

33.  Mitochondrial dysfunction, insulin resistance and potential genetic implications. Sangwung P, Petersen KF, Shulman GI, Knowles JW. Endocrinology. 2020 Feb 15. pii: bqaa017. doi: 10.1210/endocr/bqaa017. [Epub ahead of print] PMID: 32060542

34.  Sex-Specific Risks of Major Cardiovascular and Limb Events in Patients With Symptomatic Peripheral Artery Disease. Haine A, Kavanagh S, Berger JS, Hess CN, Norgren L, Fowkes FGR, Katona BG, Mahaffey KW, Blomster JI, Patel MR, Jones WS, Rockhold FW, Hiatt WR, Baumgartner I; International Steering Committee and Investigators of the EUCLID Trial. J Am Coll Cardiol. 2020 Feb 18;75(6):608-617. doi: 10.1016/j.jacc.2019.11.057. PMID: 32057375

35.  HIF1α Regulates Early Metabolic Changes due to Activation of Innate Immunity in Nuclear Reprogramming. Liu C, Ruan H, Himmati F, Zhao MT, Chen CC, Makar M, Chen IY, Sallam K, Mocarski ES, Sayed DSayed N. Stem Cell Reports. 2020 Feb 11;14(2):192-200. doi: 10.1016/j.stemcr.2020.01.006. Epub 2020 Feb 11. PMID: 32048999

36.  A Predictive Model for Intracardiac Pressures in Patients Free from Rejection or Allograft Vasculopathy After Pediatric Heart Transplantation. Mills MF, Long J, Qin F, Collins RTRosenthal DN, Almond CS, Hollander SA. Transplantation. 2020 Feb 10. doi: 10.1097/TP.0000000000003166. [Epub ahead of print] PMID: 32044891

37.  Impact of age, sex and heart rate variability on the acute cardiovascular response to isometric handgrip exercise. Cauwenberghs N, Cornelissen V, Christle JW, Hedman KMyers JHaddad F, Kuznetsova T. J Hum Hypertens. 2020 Feb 10. doi: 10.1038/s41371-020-0311-y. [Epub ahead of print] PMID: 32042073

38.  Can the 12-lead ECG distinguish RVOT from aortic cusp PVCs in pediatric patients? Clark BC, Ceresnak SR, Pass RH, Nappo L, Sumihara K, Dubin AM, Motonaga K, Moak JP. Pacing Clin Electrophysiol. 2020 Feb 10. doi: 10.1111/pace.13885. [Epub ahead of print] PMID: 32040211

39.  Invited Commentary: Reducing Sedation and Anesthesia in Pediatric Patients at MRI. Greer MC, Vasanawala SS. Radiographics. 2020 Feb 7:190211. doi: 10.1148/rg.2020190211. [Epub ahead of print] No abstract available. PMID: 32039652

40.  The use of prothrombin complex concentrate as a warfarin reversal agent in pediatric patients undergoing orthotopic heart transplantation. Sisti D, Williams GD, Ding V, Long JMaeda K, Chen S, Navaratnam M. Paediatr Anaesth. 2020 Feb 10. doi: 10.1111/pan.13839. [Epub ahead of print] PMID: 32037665

41.  Perpendicular alignment of lymphatic endothelial cells in response to spatial gradients in wall shear stress. Michalaki E, Surya VN, Fuller GGDunn AR. Commun Biol. 2020 Feb 6;3(1):57. doi: 10.1038/s42003-019-0732-8. PMID: 32029852

42.  Manganese-enhanced T1 mapping to quantify myocardial viability: validation with 18F-fluorodeoxyglucose positron emission tomography. Spath N, Tavares A, Gray GA, Baker AH, Lennen RJ, Alcaide-Corral CJ, Dweck MR, Newby DE, Yang PC, Jansen MA, Semple SI. Sci Rep. 2020 Feb 6;10(1):2018. doi: 10.1038/s41598-020-58716-x. PMID: 32029765

43.  Organ responses with daratumumab therapy in previously treated AL amyloidosis. Chung A, Kaufman GP, Sidana S, Eckhert E, Schrier SL, Lafayette RA, Arai SWitteles RMLiedtke M. Blood Adv. 2020 Feb 11;4(3):458-466. doi: 10.1182/bloodadvances.2019000776. PMID: 32027745

44.  First Experience of Transcatheter Leak Occlusion With Detachable Coils Following Left Atrial Appendage Closure. Della Rocca DG, Horton RP, Di Biase L, Bassiouny M, Al-Ahmad A, Mohanty S, Gasperetti A, Natale VN, Trivedi C, Gianni C, Burkhardt JD, Gallinghouse GJ, Hranitzky P, Sanchez JE, Natale A. JACC Cardiovasc Interv. 2020 Feb 10;13(3):306-319. doi: 10.1016/j.jcin.2019.10.022. Epub 2020 Jan 15. PMID: 31954677

45.  Comparison of Long-Term Adverse Outcomes in Patients With Atrial Fibrillation Having Ablation Versus Antiarrhythmic Medications. Freeman JV, Tabada GH, Reynolds K, Sung SH, Singer DE, Wang PJ, Liu TI, Gupta N, Hlatky MA, Go AS. Am J Cardiol. 2020 Feb 15;125(4):553-561. doi: 10.1016/j.amjcard.2019.11.004. Epub 2019 Nov 19. PMID: 31843233

46.  High-Efficiency, Selection-free Gene Repair in Airway Stem Cells from Cystic Fibrosis Patients Rescues CFTR Function in Differentiated Epithelia. Vaidyanathan S, Salahudeen AA, Sellers ZM, Bravo DT, Choi SS, Batish A, Le W, Baik R, de la O S, Kaushik MP, Galper N, Lee CM, Teran CA, Yoo JH, Bao G, Chang EH, Patel ZM, Hwang PH, Wine JJ, Milla CE, Desai TJ, Nayak JV, Kuo CJPorteus MH. Cell Stem Cell. 2020 Feb 6;26(2):161-171.e4. doi: 10.1016/j.stem.2019.11.002. Epub 2019 Dec 12. PMID: 31839569

47.  Peak oxygen pulse responses during maximal cardiopulmonary exercise testing: Reference standards from FRIEND (Fitness Registry and the Importance of Exercise: an International Database). Arena R, Myers J, Harber M, Wisloff U, Stensvold D, Kaminsky LA. Int J Cardiol. 2020 Feb 15;301:180-182. doi: 10.1016/j.ijcard.2019.11.106. Epub 2019 Nov 14. PMID: 31757647

48.  Real-time 3T MRI-guided cardiovascular catheterization in a porcine model using a glass-fiber epoxy-based guidewire. Li X, Perotti LE, Martinez JA, Duarte-Vogel SM, Ennis DB, Wu HH. PLoS One. 2020 Feb 26;15(2):e0229711. doi: 10.1371/journal.pone.0229711. eCollection 2020. PMID: 32102092

49.  Structured illumination imaging with quasi periodic patterns. Xu D, Ding J, Peng L. J Biophotonics. 2020 Feb 26:e201960209. doi: 10.1002/jbio.201960209. [Epub ahead of print] PMID: 32101369

50.  Pharmacogenomics in Asian subpopulations and impacts on commonly prescribed medications. Lo C, Nguyen S, Yang C, Witt L, Wen A, Liao TV, Nguyen J, Lin BAltman RBPalaniappan L. Clin Transl Sci. 2020 Feb 26. doi: 10.1111/cts.12771. [Epub ahead of print] Review. PMID: 32100936

51.  Systematic identification of silencers in human cells. Pang B, Snyder MP. Nat Genet. 2020 Feb 24. doi: 10.1038/s41588-020-0578-5. [Epub ahead of print] PMID: 32094911

52.  Clinical diagnosis of benign paroxysmal positional vertigo and vestibular neuritis. Johns P, Quinn J. CMAJ. 2020 Feb 24;192(8):E182-E186. doi: 10.1503/cmaj.190334. No abstract available. PMID: 32094268

53.  Diabetes and heart failure post-acute myocardial infarction: Important associations and need for evidence-based interventions. Parizo J, Mahaffey KW. Eur J Prev Cardiol. 2020 Feb 24:2047487320904232. doi: 10.1177/2047487320904232. [Epub ahead of print] No abstract available. PMID: 32090588

54.  The interconnected atrium: Acute impact of pulmonary vein isolation on remote atrial tissue. Rogers AJ, Baykaner T, Narayan SM. J Cardiovasc Electrophysiol. 2020 Feb 23. doi: 10.1111/jce.14389. [Epub ahead of print] No abstract available. PMID: 32090385

55.  Cocoa to Improve Walking Performance in Older People With Peripheral Artery Disease: The COCOA-PAD Pilot Randomized Clinical Trial. McDermott MM, Criqui MH, Domanchuk K, Ferrucci L, Guralnik JM, Kibbe MR, Kosmac K, Kramer CM, Leeuwenburgh C, Li L, Lloyd-Jones D, Peterson CA, Polonsky TS, Stein JH, Sufit R, Van Horn L, Villarreal F, Zhang D, Zhao L, Tian L. Circ Res. 2020 Feb 28;126(5):589-599. doi: 10.1161/CIRCRESAHA.119.315600. Epub 2020 Feb 14. PMID: 32078436

56.  Diagnostic Performance of Angiogram-Derived Fractional Flow Reserve: A Pooled Analysis of 5 Prospective Cohort Studies. Witberg G, De Bruyne B, Fearon WF, Achenbach S, Engstrom T, Matsuo H, Kornowski R. JACC Cardiovasc Interv. 2020 Feb 24;13(4):488-497. doi: 10.1016/j.jcin.2019.10.045. Epub 2020 Jan 29. PMID: 32007461

57.  Five-Year Outcomes of Transcatheter or Surgical Aortic-Valve Replacement. Makkar RR, Thourani VH, Mack MJ, Kodali SK, Kapadia S, Webb JG, Yoon SH, Trento A, Svensson LG, Herrmann HC, Szeto WY, Miller DC, Satler L, Cohen DJ, Dewey TM, Babaliaros V, Williams MR, Kereiakes DJ, Zajarias A, Greason KL, Whisenant BK, Hodson RW, Brown DL, Fearon WF, Russo MJ, Pibarot P, Hahn RT, Jaber WA, Rogers E, Xu K, Wheeler J, Alu MC, Smith CR, Leon MB; PARTNER 2 Investigators. N Engl J Med. 2020 Jan 29;382(9):799-809. doi: 10.1056/NEJMoa1910555. Print 2020 Feb 27. PMID: 31995682

58.  Nanotherapeutic Shots through the Heart of Plaque. Kanthi Y, de la Zerda A, Smith BR. ACS Nano. 2020 Feb 25;14(2):1236-1242. doi: 10.1021/acsnano.0c00245. Epub 2020 Jan 27. PMID: 31986012

59.  PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling. Rykaczewska U, Suur BE, Röhl S, Razuvaev A, Lengquist M, Sabater-Lleal M, van der Laan SW, Miller CL, Wirka RC, Kronqvist M, Gonzalez Diez M, Vesterlund M, Gillgren P, Odeberg J, Lindeman JH, Veglia F, Humphries SE, de Faire U, Baldassarre D, Tremoli E; IMPROVE study group, Lehtiö J, Hansson GK, Paulsson-Berne G, Pasterkamp G, Quertermous T, Hamsten A, Eriksson P, Hedin U, Matic L. Circ Res. 2020 Feb 28;126(5):571-585. doi: 10.1161/CIRCRESAHA.119.316063. Epub 2020 Jan 2. PMID: 31893970