Stanford-Penn
Cardiovascular Symposium

November 4 - 5, 2019

Paul Berg Hall | Li Ka Shing Building

Stanford, California

Speakers

Joseph Wu, MD, PhD

Director, Stanford CVI
Simon H. Stertzer, MD, Professor of Medicine and Radiology, Stanford School of Medicine

Lloyd Minor, MD

The Carl and Elizabeth Naumann Professorship for the Dean of the School of Medicine, Stanford School of Medicine

Paul Wang, MD

Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine

Saman Nazarian, MD, PhD

Associate Professor Of Medicine, Perelman School of Medicine, University Of Pennsylvania

Yasuhiro Shudo, MD

Clinical Assistant Professor, Cardiothoracic Surgery (Adult Cardiac Surgery), Stanford School of Medicine

Thomas P. Cappola, MD, ScM

Herbert C. Rorer Professor in Medical Sciences, Perelman School of Medicine

Bonnie Ky, MD, MSCE

Associate Professor Of Medicine, Perelman School of Medicine, University of Pennsylvania

Marlene Rabinovitch, MD

Dwight and Vera Dunlevie Professor in Pediatric Cardiology, Stanford School of Medicine

Sean Wu, MD, PhD

Associate Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine

Kristy Red-Horse, PhD

Associate Professor of Biology, Stanford School of Medicine

Ioannis Karakikes, PhD

Assistant Professor (Research) in the Department of Cardiothoracic Surgery, Stanford School of Medicine.

Mark Mercola, PhD

Professor of Medicine (Cardiovascular), Stanford School of Medicine

Alison Marsden, PhD

Associate Professor of Pediatrics (Cardiology) and Bioengineering, Stanford School of Medicine

Elsie Ross, MD

Assistant Professor of Surgery (Vascular Surgery) and of Medicine (Bmir), Stanford School of Medicine

Vicki Parikh, MD, PhD

Assistant Professor of Medicine
Stanford School of Medicine

Karim Sallam, MD

Assistant Professor, Medicine (Cardiovascular Medicine), Stanford School of Medicine

Robert Wirka, MD

Instructor, Medicine (Cardiovascular Medicine), Stanford School of Medicine

Dan Kelly, MD

Willard And Rhoda Ware Professor Of Diabetes And Metabolic Diseases, Perelman School of Medicine

Bob Harrington, MD

Arthur L. Bloomfield Professor of Medicine and Chair, Department of Medicine, Stanford School of Medicine

Daria Mochly-Rosen, PhD

George D. Smith Professor in Translational Medicine, Stanford School of Medicine

Elan Burton, MD

Clinical Assistant Professor, Cardiothoracic Surgery (Adult Cardiac Surgery), Stanford School of Medicine

Shipra Arya, MD, SM, FACS

Associate Professor of Surgery (Vascular Surgery), Stanford School of Medicine

Kiran Khush, MD

Associate Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine

Daniel J. Rader, MD

Seymour Gray Professor of Molecular Medicine, Perelman School of Medicine, University of Pennsylvania

Vinicio de Jesus Perez, MD

Associate Professor of Medicine (Pulmonary and Critical Care Medicine), Stanford School of Medicine

Rajan Jain, MD

Assistant Professor Of Medicine, Perelman School of Medicine, University of Pennsylvania

Patricia Nguyen, MD

Assistant Professor of Medicine (Cardiovascular Medicine), Palo Alto Veterans Affairs Health Care System

Ngan Huang, PhD

Assistant Professor (Cardiothoracic Surgery), Stanford School of Medicine

Ronglih Liao, PhD

Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine

Nicholas Leeper, MD

Professor of Surgery (Vascular Surgery) and Medicine (Cardiovascular Medicine), Stanford School of Medicine

Joshua Knowles, MD

Assistant Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine

June Rhee, MD

Instructor, Medicine (CV Medicine) and Postdoctoral Research Fellow (CV Medicine), Stanford School of Medicine

Nazish Sayed, MD, PhD

Instructor, Cardiovascular Institute, Stanford School of Medicine

Celina Yong, MD, MBA, MSc

Assistant Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine

Erik Ingelsson, PhD

Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine

Peter Fitzgerald, MD, PhD

Professor (Research) Of Medicine (Cardiovascular), Emeritus

Sarah Heilshorn, PhD

Associate Professor of Materials Science and Engineering, Stanford School of Medicine

William Hiesinger, MD

Assistant Professor of Cardiothoracic Surgery (Adult Cardiac Surgery), Stanford School of Medicine

Sharon Hunt, MD

Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine, Emerita

Ron Witteles, MD

Associate Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine

Edda Spiekerkoetter, MD

Associate Professor of Medicine (Pulmonary and Critical Care Medicine), Stanford School of Medicine

Edward E. Morrissey, PhD

Robinette Foundation Professor of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania

James Priest, MD

Assistant Professor of Pediatrics (Cardiology) at the Stanford University Medical Center, Stanford School of Medicine

Kiran Musunuru, MD, PhD, MPH

Associate Professor Of Medicine, Perelman School of Medicine, University of Pennsylvania

Zoltan Arany, MD, PhD

Professor of Medicine, Perelman School of Medicine, University of Pennsylvania

Scott Damrauer, MD

Assistant Professor of Surgery, Perelman School of Medicine, University of Pennsylvania

Kevin Alexander, MD

Instructor, Cardiovascular Institute, Stanford School of Medicine

Ian Chen, MD, PhD

Staff, Cardiovascular Institute Operations, Stanford School of Medicine

Fatima Rodriguez, MD, MPH

Assistant Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine

Hanjay Wang, MD

Resident, Cardiothoracic Surgery, Stanford School of Medicine

Agenda

Day 1 - November 4, 2019

noon-1:00 pm | Registration and Light Lunch

Introductory Remarks

1:00-1:05 pm | Welcome

Joseph Wu, MD, PhD
Director, Stanford Cardiovascular Institute
Simon H. Stertzer, MD, Professor of Medicine and Radiology Stanford University

Daniel P. Kelly, MD
Willard And Rhoda Ware Professor Of Diabetes And Metabolic Diseases, Perelman School of Medicine, University of Pennsylvania

Erik Ingelsson, PhD
Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine

1:05-1:10 pm | Introductory Remarks

Lloyd Minor, MD
The Carl and Elizabeth Naumann Professorship for the Dean of the School of Medicine, Professor of Otolaryngology—Head & Neck Surgery, Stanford School of Medicine

1:10-1:15 pm | Welcome

Bob Harrington, MD
Arthur L. Bloomfield Professor of Medicine and Chair, Department of Medicine, Stanford School of Medicine

Opening Keynote

1:15-1:45 pm

Peter Fitzgerald, MD, PhD • "Future in Health: Drugs, Devices, and Data"
Professor Emeritus of Cardiovascular Medicine Professor Emeritus, Medicine & Engineering Director, Center of CV Innovation
Stanford University
Co-founder and Managing partner, Triventures

Novel Technologies in Cardiovascular Medicine

Session Chair: Paul J. Wang, MD, Professor of Cardiovascular Medicine, and, by courtesy, of Bioengineering, Stanford University

1:45-2:30 pm

Daria Mochly-Rosen, PhD • "βIIPKC Inhibitor(s), Heart Failure and SAMβA"
The George D. Smith Professor in Translational Medicine, Stanford School of Medicine

Sarah Heilshorn, PhD • "Engineering of Materials to Enable Regenerative Medicine"
Associate Professor of Materials Science and Engineering, Stanford School of Medicine

Saman Nazarian, MD, PhD • "Anatomy of Reentrant Arrhythmias: Connecting Physiology to Imaging"
Associate Professor Of Medicine, Perelman School of Medicine, University Of Pennsylvania

2:30-3:00 pm | Break

Recent Advances in Cardiovascular Surgery

Session Chair: Elan Burton, MD, Clinical Assistant Professor, Adult Cardiothoracic Surgery, Stanford University

3:00-3:45 pm

William Hiesinger, MD • "Minimally Invasive Mechanical Circulatory Support"
Assistant Professor of Cardiothoracic Surgery (Adult Cardiac Surgery), Stanford School of Medicine

Yasuhiro Shudo, MD • "Heart and Heart-Lung Transplantation"
Clinical Assistant Professor, Cardiothoracic Surgery (Adult Cardiac Surgery), Stanford School of Medicine

Shipra Arya, MD, SM, FACS • "Complex Endovascular Aneurysm Repair"
Associate Professor of Surgery (Vascular Surgery), Stanford School of Medicine

The Many Faces of Heart Failure

Session Chair: Sharon Hunt, MD, Professor Emerita of Cardiovascular Medicine, Stanford University

3:45-4:45 pm

Thomas P. Cappola, MD, ScM • "Genomics of Heart Failure"
Herbert C. Rorer Professor in Medical Sciences, Perelman School of Medicine, University of Pennsylvania

Ron Witteles, MD • "Amyloidosis – Breaking Down the Myths"
Associate Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine

Bonnie Ky, MD, MSCE • "Translational Insights into Cancer Therapy Cardiotoxicity"
Associate Professor Of Medicine, Perelman School of Medicine, University of Pennsylvania

Day 2 - November 5, 2019

7:30-8:15 am | Arrival and Breakfast

Introductory Remarks

8:10-8:15 am | Welcome

Erik Ingelsson, MD, PhD
Professor of Cardiovascular Medicine Stanford University

Keynote Lecture

8:15-8:45 am

Daniel J. Rader, MD • "A Genome-First Approach to Cardiometabolic Disease"
Seymour Gray Professor of Molecular Medicine, Perelman School of Medicine, University of Pennsylvania

New Landscape in Cardiopulmonary Diseases

Session Chair: Edda Spiekerkoetter, MD, Associate Professor of Pulmonary and Critical Care Medicine, Stanford University

8:45-9:30 am

Marlene Rabinovitch, MD • "Impact of Genetics on Metabolism and Epigenetics in Pulmonary Arterial Hypertension"
Dwight and Vera Dunlevie Professor in Pediatric Cardiology, Stanford School of Medicine

Vinicio de Jesus Perez, MD • "Endothelial Cells, Pericytes and Pulmonary Hypertension: WNTr is Coming!"
Associate Professor of Medicine (Pulmonary and Critical Care Medicine), Stanford School of Medicine

Kiran Khush, MD • "Non-Invasive Monitoring for Heart Transplant Complications"
Associate Professor of Cardiovascular Medicine, Stanford School of Medicine

9:30-10:00 am | Break

Cardiovascular Development: What’s Wrong and How to Get it Right?

Session Chair: Sean M. Wu, MD, PhD, Associate Professor of Cardiovascular Medicine, Stanford University

10:00-10:45 am

Rajan Jain, MD • "3D Genome Organization in Development and Disease"
Assistant Professor Of Medicine, Perelman School of Medicine, University of Pennsylvania

James Priest, MD • "Polygenic Determinants of Aortic Diameter Predict Risk for Aneurysm and Dissection"
Assistant Professor of Pediatrics (Cardiology) at the Stanford University Medical Center, Stanford School of Medicine

Kristy Red-Horse, PhD • "Role of Coronary Vessels in Cardiac Development and Regeneration"
Associate Professor of Biology, Stanford School of Medicine

Stem Cells and Regenerative Medicine: From Developmental Biology to Precision Medicine

Session Chair: Patricia Nguyen, MD, Assistant Professor of Cardiovascular Medicine, Palo Alto Veterans Affairs Health Care System, Stanford Medicine

10:45-11:30 am

Ioannis Karakikes, PhD • "The Silence of the LADs: Lamina-Genome Interaction in Cardiac Laminopathies"
Assistant Professor (Research) in the Department of Cardiothoracic Surgery, Stanford School of Medicine

Ngan Huang, PhD • "Application of iPSC-Derived Endothelial Cells for Treatment of Peripheral Arterial Disease"
Assistant Professor (Cardiothoracic Surgery), Stanford School of Medicine, and Principal Investigator (Veterans Affairs Palo Alto Health Care System)

Kiran Musunuru, MD, PhD, MPH • "Diagnosis, Prevention, And Treatment Of Cardiovascular Diseases With Genome Editing"
Associate Professor Of Medicine, Perelman School of Medicine, University of Pennsylvania

11:30-1:00 pm | Lunch, Mentor Tables, and Poster Session

Cardiac Metabolism: From Biology to Disease

Session Chair: Mark Mercola, PhD, Professor of Medicine, Cardiovascular Medicine, Stanford University

1:00-1:45 pm

Daniel P. Kelly, MD • "Deciphering the Metabolic Origins of Heart Failure"
Willard And Rhoda Ware Professor Of Diabetes And Metabolic Diseases, Perelman School of Medicine, University of Pennsylvania

Ronglih Liao, PhD • "Metabolic Underpinnings of Amyloid Cardiomyopathy"
Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine

Zoltan Arany, MD, PhD • "Novel Players in Mitophagy"
Professor of Medicine, Perelman School of Medicine, University of Pennsylvania

New Insights into Vascular Disease: From Bench to Bedside

Session Chair: Alison Marsden, PhD, Associate Professor of Pediatrics (Cardiology) and Bioengineering, Stanford University

1:45-2:30 pm

Nicholas Leeper, MD • "Clonal Smooth Muscle Cell Expansion in Atherosclerosis"
Associate Professor of Surgery (Vascular Surgery) and Medicine (Cardiovascular Medicine), Stanford School of Medicine

Scott Damrauer, MD • "Vascular Genetics at Scale: Lessons from the VA Million Veteran Program"
Assistant Professor of Surgery, Perelman School of Medicine, University of Pennsylvania

Elsie Ross, MD • "The Use of Big Data and Machine Learning to Identify and Refine Important Cardiovascular Phenotypes"
Assistant Professor of Surgery (Vascular Surgery) and of Medicine (BMIR), Stanford School of Medicine

2:30-3:00 pm | Break

Rapid Fire Talks

Session Chair: Joshua W. Knowles, MD, PhD, Assistant Professor of Cardiovascular Medicine, Stanford University

3:00-4:15 pm | 5 minute talk, 2 minute Q&A

Kevin Alexander, MD • "Molecular Insights from an In Vivo Model of Transthyretin Cardiac Amyloidosis"
Fellow in Medicine, Stanford School of Medicine

Ian Chen, MD, PhD • "Leaflet-Specific Contribution to Aortic Stenosis: Insights from Computed Tomography and Computer Simulation"
Instructor, Cardiovascular Institute, Stanford School of Medicine

Victoria Parikh, MD • "Polygenic Determinants of Aortic Diameter Predict Risk for Aneurysm and Dissection"
Assistant Professor of Medicine, Cardiovascular Medicine, Stanford University

June-Wha Rhee, MD • "Investigating the Mechanism of Trastuzumab-induced Cardiotoxicity Using Human iPSC-derived Cardiac Organoids"
Instructor, Cardiovascular Medicine, Stanford University

Marie A. Guerraty, MD, PhD • "The Role of Friend of GATA2 (FOG2/ZFPM2) in Angiogenesis and Coronary Microvascular Disease"
Instructor, Division of Cardiovascular Medicine, University of Pennsylvania

Karim Sallam, MD • "Cellular Models to Tailor Cardiac Drug Therapy"
Assistant Professor of Cardiovascular Medicine, Stanford University

Nazish Sayed, MD, PhD • "Statins Improve Endothelial Function in LMNA-Related Dilated Cardiomyopathy: Clinical Trial in a Dish Using Human iPSCs"
Instructor, Cardiovascular Institute, Stanford University

Fatima Rodriguez, MD, MPH • "Cardiovascular Risk Prediction for Understudied Populations"
Assistant Professor of Cardiovascular Medicine, Stanford University

Robert Wirka, MD • "Single Cell Analysis of Smooth Muscle Cell Phenotypic Modulation In Vivo Reveals a Critical Role for Coronary Disease Gene TCF21 in Mice and Humans"
Instructor, Cardiovascular Medicine, Stanford University

Celina Yong, MD, MBA, MSc • "Gender Inequities in the Cardiology Profession"
Assistant Professor of Cardiovascular Medicine, Stanford University

Hanjay Wang, MD • "The Cardiac Surgeon-Scientist at the Crossroads of Basic Science, Engineering, and Clinical Translation"
Resident, Cardiothoracic Surgery, Stanford University

Closing Remarks

4:17-4:20 pm

Joseph C. Wu, MD, PhD
Director, Stanford Cardiovascular Institute
Simon H. Stertzer, MD, Professor of Medicine and Radiology Stanford University

4:20 pm | Wine and Cheese Reception and Poster Session with Presentation of Poster Awards

Organizing Committee

Erik Ingelsson, PhD (Chair)

Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine

Ngan Huang, PhD

Assistant Professor (Cardiothoracic Surgery), Stanford School of Medicine

Ronglih Liao, PhD

Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine

Joshua Knowles, MD

Assistant Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine

Phil Tsao, PhD

Professor (Research) of Medicine (Cardiovascular Medicine), Stanford School of Medicine

Nicholas Leeper, MD

Associate Professor of Surgery (Vascular Surgery) and Medicine (Cardiovascular Medicine), Stanford School of Medicine

Sean Wu, MD, PhD

Associate Professor of Medicine (Cardiovascular Medicine), Stanford School of Medicine

November 4 - 5, 2019

Paul Berg Hall | Li Ka Shing Building

Stanford, California

| Program |

| View the Abstracts |

Speakers

Joseph Wu, MD, PhD

Lloyd Minor, MD

Paul Wang, MD

Saman Nazarian, MD, PhD

Yasuhiro Shudo, MD

Thomas P. Cappola, MD, ScM

Bonnie Ky, MD, MSCE

Marlene Rabinovitch, MD

Sean Wu, MD, PhD

Kristy Red-Horse, PhD

Ioannis Karakikes, PhD

Mark Mercola, PhD

Alison Marsden, PhD

Elsie Ross, MD

Vicki Parikh, MD, PhD

Karim Sallam, MD

Robert Wirka, MD

Dan Kelly, MD

Bob Harrington, MD

Daria Mochly-Rosen, PhD

Elan Burton, MD

Shipra Arya, MD, SM, FACS

Kiran Khush, MD

Daniel J. Rader, MD

Vinicio de Jesus Perez, MD

Rajan Jain, MD

Patricia Nguyen, MD

Ngan Huang, PhD

Ronglih Liao, PhD

Nicholas Leeper, MD

Joshua Knowles, MD

June Rhee, MD

Nazish Sayed, MD, PhD

Celina Yong, MD, MBA, MSc

Erik Ingelsson, PhD

Peter Fitzgerald, MD, PhD

Sarah Heilshorn, PhD

William Hiesinger, MD

Sharon Hunt, MD

Ron Witteles, MD

Edda Spiekerkoetter, MD

Edward E. Morrissey, PhD

James Priest, MD

Kiran Musunuru, MD, PhD, MPH

Zoltan Arany, MD, PhD

Scott Damrauer, MD

Kevin Alexander, MD

Ian Chen, MD, PhD

Fatima Rodriguez, MD, MPH

Hanjay Wang, MD

Agenda

Day 1 - November 4, 2019

Day 2 - November 5, 2019

Organizing Committee

Erik Ingelsson, PhD (Chair)

Ngan Huang, PhD

Ronglih Liao, PhD

Joshua Knowles, MD

Phil Tsao, PhD

Nicholas Leeper, MD

Sean Wu, MD, PhD