Sophisticated biochemical, cell biological, and genomic approaches
What We Do
In the Artandi Lab, we use sophisticated biochemical, cell biological and genomic approaches to understand the fundamental causes of these diseases. Our goal is to develop new therapeutic approaches to tackle these often intractable disease states.
Tissue Homeostasis and Regeneration
Maintenance of many tissues fails with advanced aging and disease. We study the underlying mechanisms governing tissue homeostasis and repair.
Telomeres and Human Disease
Impaired function of telomeres - the caps that protect chromosome ends - occurs with normal aging and in settings of disease. Telomere dysfunction impairs tissue regeneration and blocks cancer development. We seek to understand how this process influences degenerative disease and cancer.
Origins of Cancer
The cellular origins of cancer remain largely mysterious. We study the early stages of human carcinogenesis and how cancers acquire cellular immortality.
Congratulations to Dr. Caitlin Roake who defended her thesis last week! and for her exciting publication in Molecular Cell defining how telomerase RNA is processed in health and in disease.
Recent Publications
Acinar cell clonal expansion in pancreas homeostasis
Neuhöfer P, Roake CM, Kim SJ, Lu RJ, West RB, Charville GW and Artandi SE.
