Research Articles

• Sainz AG, Kwak CS, Cho KB, Sripadanna SA, Bergsneider BH, Zizzo Z, Durairaj AS, Du Z, Cooney I, Venida A, Bharucha N, Karakikes I, Chiu W, Lim M, Bassik MC, Wang X. (2026) The MIRO1-BAX Complex Dictates Life and Death at the Mitochondrial Gate. bioRxiv.
• Sujyoti Chandra, Chulhwan S. Kwak, Zehui Du, Giuseppe Barisano, Kong T. Nguyen, Vlad Vinogradov and Xinnan Wang (2026) Chemical Modulation of Miro1 Alleviates Cell-Type-Specific Vulnerabilities in Friedreich’s Ataxia. Cell Chemical Biology.
• Du Z, Li M, Bergsneider BH, Tsai AP, Cho KB, Kim LH, Choi J, Li G, Wyss-Coray T, Lim M, Wang X. (2026) Cross-Species Transcriptomic Integration Reveals a MIRO1-Mediated Macrophage-T Cell Axis in Glioma. Life Science Alliance 2026;9(8). 
• Kwak, C. S., Du, Z., Creery, J. S., Wilkerson, E. M., Major, M. B., Elias, J. E., Wang, X. (2025) Optogenetic Proximity Labeling Maps Spatially Resolved Mitochondrial Surface Proteomes and a Locally Regulated Ribosome Pool. bioRxiv
• Bhagaban Mallik, Sajad A. Bhat, Xinnan Wang, C. Andrew Frank. (2025) Mitochondrial Complex I and ROS control neuromuscular function through opposing pre- and postsynaptic mechanisms. (2025) PLoS Biol. Sep 22;23(9):e3003388. doi: 10.1371/journal.pbio.3003388. PMID: 40982549.
• Jackson CM, Pant A, Dinalankara W, Choi J, Jain A, Nitta R, Yazigi E, Saleh L, Zhao L, Nirschl TR, Kochel CM, Hwa-Lin Bergsneider B, Routkevitch D, Patel K, Cho KB, Tzeng S, Neshat SY, Kim YH, Smith BJ, Ramello MC, Sotillo E, Wang X, Green JJ, Bettegowda C, Li G, Brem H, Mackall CL, Pardoll DM, Drake CG, Marchionni L, Lim M. (2024) The cytokine Meteorin-like inhibits anti-tumor CD8+ T cell responses by disrupting mitochondrial function. Immunity. Aug 13;57(8):1864-1877.e9. doi: 10.1016/j.immuni.2024.07.003. PMID: 3911131.
• Chulhwan S Kwak,Furkan E Oflaz,Jiamin Qiu,Xinnan Wang.(2024)Human stem cell-specific epigenetic signatures control transgene expression.Biochim Biophys Acta.Oct 20:195063. PMID:39437851.
• Sujyoti Chandra, Parul Katiyar, Aarooran S. Durairaj,Xinnan Wang.(2024) Mitochondrial Calcium Transport During Autophagy Initiation.Mitochondrial Communications.2 (2024) 14-20.
• Vinita Bharat,Aarooran S. Durairaj, RoelandVanhauwaert, Li Li, Colin M. Muir, Sujyoti Chandra, Chulhwan S. Kwak, Yann Le Guen, Pawan Nandakishore, Chung-Han Hsieh,Stefano E. Rensi,Russ B.Altman,Michael D. Greicius,Liang Feng,andXinnan Wang. (2023)A Mitochondrial Inside-Out Iron-Calcium Signal Reveals Drug Targets for Parkinson's Disease.Cell Reports42, 113544.
• Vinita Bharat, Chung-Han Hsieh, and Xinnan Wang. (2021) Mitochondrial defects in fibroblasts of pathogenic MAPT patients. Frontiers in Cell and Developmental Biology.
• Li Li, Devon M. Conradson, Vinita Bharat, Min Joo Kim, Chung-Han Hsieh, Paras S. Minhas, Amanda M. Papakyrikos, Aarooran Sivakumaran Durairaj, Anthony Ludlam, Katrin I. Andreasson, Linda Partridge, Michael A. Cianfrocco, and Xinnan Wang. (2021) A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation. Nature Metabolism
  
• David Nguyen, Vinita Bharat, Devon M. Conradson, Pawan Nandakishore, and Xinnan Wang (2021) Miro1 impairment in a Parkinson's at-risk cohort. Frontiers in Molecular Neuroscience
• Yinsuo Zhao, Eli Song, Wenjuan Wang, Chung-Han Hsieh, Xinnan Wang, Wei Feng, Xiangming Wang, and Kang Shen. (2021) Metaxins are core components of mitochondria transport adaptor complexes. Nature Communications 12:83
  
• Amanda M. Papakyrikos, Min Joo Kim, and Xinnan Wang. (2020) Drosophila PTPMT1 has a function in tracheal air-filling. (2020) iScience
• Ashley E. Gonzalez, Xinnan Wang. (2020) Drosophila VCP/p97 mediates dynein-dependent retrograde mitochondrial motility in axons. Frontiers in Cell and Developmental Biology
• Chung-Han Hsieh*, Li Li*, Roeland Vanhauwaert, Kong Nguyen, Mary D. Davis, Guojun Bu, Zbigniew K. Wszolek, and Xinnan Wang. (2019) Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models. Cell Metabolism *: co-first author
• Atossa Shaltouki*, Chung-Han Hsieh*, Min Joo Kim, Xinnan Wang. (2018) Alpha-Synuclein Delays Mitophagy and Targeting Miro Rescues Neuron Loss in Parkinson's Models. Acta Neuropathologica *co-first author
• Meredith M. Course, Anna I. Scott, Carmen Schoor, Chung-Han Hsieh, Amanda M. Papakyrikos, Dominic Winter, Tina M. Cowan, and Xinnan Wang (2018) Phosphorylation of MCAD selectively rescues PINK1 deficiencies in behavior and metabolism. Molecular Biology of the Cell doi:10.1091/mbc.E18-03-0155
• Pei-I Tsai,Chin-Hsien Lin,Chung-Han Hsieh,Amanda M. Papakyrikos,Min Joo Kim,Valerio Napolioni,Carmen Schoor,Julien Couthouis,Ruey-Meei Wu,Zbigniew K. Wszolek,Dominic Winter,Michael D. Greicius,Owen A. Ross,and Xinnan Wang.PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions.(2018) Molecular Cell
• Pei-I Tsai*, Amanda M Papakyrikos*, Chung-Han Hsieh, Xinnan Wang. Drosophila MIC60/Mitofilin Conducts Dual Roles in Mitochondrial Motility and Crista Structure. (2017). Molecular Biology of the Cell doi:10.1091/mbc.E17-03-0177.*: co-first author
• Hsieh CH, Shaltouki A, Gonzalez A, Betterncourt da Cruz A, Burbulla L, St. Lawrence E, Schule B, Krainc D, Palmer T, Wang X. Functional impairment in Miro degradation and mitophagy is a shared feature in Familial and Sporadic Parkinson's Disease. Cell Stem Cell. 2016. http://dx.doi.org/10.1016/j.stem.2016.08.002
• Lawson N, Hsieh CH, March D, Wang X. Elevated Energy Production in Chronic Fatigue Syndrome Patients. J. Nat. Sci. 2(10): e221, 2016.
• Meredith M. Course, Chung-Han Hsieh, Pei-I Tsai, Jennifer Codding-Bui, Atossa Shaltouki, and Xinnan Wang. (2017). Live imaging mitochondrial transport in neurons. Techniques to Investigate Mitochondrial Function in Neurons. 2017:49-66.
• Tsai PI, Course MM, Lovas JR, Hsieh CH, Babic M, Zinsmaier KE, Wang X. PINK1-mediated phosphorylation of Miro inhibits synaptic growth and protects dopaminergic neurons in Drosophila. Scientific Reports 4:6962, 2014. PMCID:PMC4223694.
• Pekkurnaz G, Trinidad JC, Wang X, Kong D, Schwarz TL. Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. Cell 158(1):54-68. 2014. PMCID:PMC4224014.
• Wang X, Winter D, Ashrafi G, Schlehe J, Wong Y, Selkoe D, Rice S, Steen J, LaVoie M, Schwarz TL. PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 147:893-906, 2011. PMCID: PMC3261796.
• Wang X, Schwarz TL. The mechanism of Ca2+-dependent regulation of kinesin-mediated mitochondrial motility. Cell 136: 163-174, 2009. PMCID: PMC2768392.
• Wang X, Schwarz TL. Imaging axonal transport of mitochondria. Methods Enzymol 457:319-333, 2009. PMCID: PMC2996865.
• Tsang HT, Edwards TL, Wang X, Connell JW, Davies RJ, Durrington HJ, O'Kane CJ, Luzio JP, Reid E. The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signaling. Hum Mol Genet 18: 3805-21, 2009. PMCID: PMC2748891.
• Wang X, Shaw WR, Tsang HTH, Reid E, and O'Kane CJ. Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules. Nat Neurosci 10: 177-185, 2007. PMCID: PMC2464677.

           Reviews and Perspectives

• Alva G. Sainz, Xinnan Wang (2026) Mitochondrial molecular diversity in the brain. Current Opinion in Neurobiology 2026 Sep 3;101:103270. doi: 10.1016/j.conb.2026.103270.
• Alva G. Sainz, Furkan E. Oflaz, Xinnan Wang (2025) Sensing within: Mitochondrial inside-out signal transduction. Cell Chemical Biology 32, October 16, 2025
• Gulcin Pekkurnaz and Xinnan Wang. (2022). Mitochondrial heterogeneity and homeostasis through the lens of a neuron. Nature Metabolism
• Vinita Bharat, and Xinnan Wang. (2020). Precision neurology for Parkinson's disease: coupling Miro1-based diagnosis and drug discovery. Movement Disorders.
• Roeland Vanhauwaert, Vinita Bharat, and Xinnan Wang. (2019). Surveillance and transportation of mitochondria in neurons. Current Opinion in Neurobiology 57:87-93.
  
• Wang X. (2017) Destructive cellular paths underlying familial and sporadic Parkinson's disease converge on mitophagy. Autophagy. DOI: 10.1080/15548627.2017.
  
• Course MM, Wang X. Transporting mitochondria in neurons. F1000Research 5 (F1000 Faculty Rev): 1735 (doi: 10.12688/f1000research.7864.1), 2016.
• van der Bliek A, Wang X. Organelles and Spatial Organization of the Cell: Organelle Homeostasis and Turnover. Molecular Biology of the Cell 27: 873-374, 2016.
• Lovas J, Wang X. The Meaning of Mitochondrial Movement to a Neuron's Life. BBA. Mol. Cell Res. 1833: 184-194, 2013.
• Frank CA, Wang X, Collins CA, Rodal AA, Yuan Q, Verstreken P, Dickman DK. New Approaches for Studying Synaptic Development, Function and Plasticity Using Drosophila as a Model System. J Neurosci 33(45): 17560-8, 2013.
• Wang X, O'Kane CJ. Chapter 10: Hereditary spastic paraplegia genes in Drosophila: dissecting their roles in axonal degeneration and intracellular traffic. Drosophila: A Toolbox for the Study of Neurodegenerative Disease. SEB Experimental Biology Series 60, Taylor & Francis Group, pp. 161-182, 2008.
• Goldstein, AYN, Wang X, Schwarz, TL. Axonal transport and delivery of presynaptic components. Curr Opin Neurobiol 18: 495-503, 2008. PMCID: PMC2653082.

           Lab Patents

• Miro1-binding compounds for treating neurodegenerative and neoplastic diseases
• 23-1115-US-PRO Compositions and methods for treating glioblastoma
• PCT/US2022/041930 A Small Molecule Therapeutic for Friedreich's Ataxia and Tauopathy
• US63/228,505T-Type Calcium Channel Antagonists and Uses Thereof
• WO2021046322A1A small molecule therapeutic for parkinson's disease paired with a biomarker of therapeutic activity
• AU2020343009A1Methods and compounds modifying mitochondrial function