Welcome to the Xinnan Wang Lab

Mitochondria move and undergo fission and fusion in all eukaryotic cells. The accurate allocation of mitochondria in neurons is particularly critical due to the significance of mitochondria for ATP supply, Ca++ homeostasis and apoptosis and the importance of these functions to the distal extremities of neurons. In addition, defective mitochondria, which can be highly deleterious to a cell because of their output of reactive oxygen species, need to be repaired by fusing with healthy mitochondria or cleared from the cell. Thus mitochondrial cell biology poses critical questions for all cells, but especially for neurons: how the cell sets up an adequate distribution of the organelle; how it sustains mitochondria in the periphery; and how mitochondria are removed after damage. The goal of our research at the Xinnan Wang Lab is to understand the regulatory mechanisms controlling mitochondrial dynamics and function and the mechanisms by which even subtle perturbations of these processes may contribute to neurodegenerative disorders.

Media Attention:

• Classy Class: https://www.ssbprobe.com/articles/2022/2/11/nsur-81n-offers-introduction-to-neuroscience-research
• Brains Behind the Institute: https://neuroscience.stanford.edu/news/brains-behind-institute/xinnan-wang
• Neurology Today: https://journals.lww.com/neurotodayonline/Fulltext/2019/11070/Mitochondrial_Protein_Emerges_as_a_Strong.7.aspx
• Reuters Health: https://www.managedhealthcareconnect.com/content/miro1-reducer-promising-parkinsons-disease-models
• Science of Parkinson’s: https://scienceofparkinsons.com/2019/10/08/miro/
• Stanford Scope: https://scopeblog.stanford.edu/2019/09/26/potential-diagnostic-hope-for-a-parkinsons-disease-treatment/
• Stanford Medicine Press Release: http://med.stanford.edu/news/all-news/2019/09/scientists-find-potential-diagnostic-tool-treatment.html
• Interview with Vinita by Stanford News: https://news.stanford.edu/2018/05/24/connecting-science-world/
• CIRM Blog World Parkinson’s Day: https://blog.cirm.ca.gov/2018/04/11/celebrating-exciting-cirm-funded-discovery-research-on-world-parkinsons-day/
• Interview with Xinnan by SfN: http://neuronline.sfn.org/Articles/Career-Paths/2018/Where-Mitochondrial-Disease-Research-Is-Heading
• Stanford Scope: http://scopeblog.stanford.edu/2018/02/21/defects-in-mitochondria-cells-internal-power-packs-further-linked-to-parkinsons-in-stanford-study/
• Scientific American: http://www.scientificamerican.com/article/promising-links-found-between-different-causes-of-parkinson-s/
• US News: http://health.usnews.com/health-care/articles/2016-09-08/cellular-defect-may-be-linked-to-parkinsons-study
• Vocativ: http://www.vocativ.com/357145/scientists-discover-mechanism-for-parkinsons-disease/
• CIRM Blog: https://blog.cirm.ca.gov/category/disease-areas/lung-disease/
• San Diego Union Tribune: http://www.sandiegouniontribune.com/news/2016/sep/08/parkinsons-mitochondria-stanford/
• Stanford Medicine Press Release: http://med.stanford.edu/news/all-news/2016/09/common-molecular-mechanism-of-parkinsons-pathology-discovered.html
• Stanford Scope: http://scopeblog.stanford.edu/2016/09/08/lrrking-in-the-shadows-likely-hidden-pathological-mechanism-of-parkinsons-disease/
• Stanford Neuroscience Institute: https://neuroscience.stanford.edu/news/mitochondrial-meltdown-parkinson’s-disease-q-neuroscientist-xinnan-wang
• Healthrising, dedicated to providing timely, accurate information to people with chronic fatigue syndrome (ME/CFS) and fibromyalgia: https://www.healthrising.org/blog/2017/04/18/stanford-paradox-elevated-energy-production-found-chronic-fatigue-syndrome-mecfs/
  
• Phoenix Rising, Prominent Chronic Fatigue Syndrome/ME Forum: http://forums.phoenixrising.me/index.php?threads/elevated-energy-production-in-chronic-fatigue-syndrome-patients.47443/page-6#post-779980
• Huffington Post: http://www.huffingtonpost.com/don-c-reed/parkinsons-vs-the-califor_b_8181786.html

Awards & Grants:

• Stanford Wu Tsai Neurosciences Institute Neuroscience:Translate Award 2024-2025
• National Institute of Neurological Disorders and Stroke, 2022
• Friedreich's Ataxia Research Alliance Grant 2022
• MJFF Outcome Measures Grant 2022
• Stanford Wu Tsai Neurosciences Institue Seed Grant 2021
• Stanford Spectrum CTSA Grant 2021
• Scholar-Innovator 2021, Harrington Discovery Institute
• National Institute of General Medical Sciences, 2021
  
• Warren Alpert Foundation
• Stanford Women’s Health and Sex Differences in Medicine Center Seed Grant
• Stanford Maternal and Child Health Research Institute Pilot Grant
• MJFF 2019 Biomarker Development for PD Award
• National Institute of Aging
• Stanford SPARK Award
• 2019 iAward (Sanofi)
• 2018 McCormick and Gabilan Faculty Award, Stanford University
• Parkinson’s Disease Seed Grant, Stanford University
• Mitokinin
• Department of Defense
• NINDS Research Project Grant (Parent R01)
• The Archer Award
• Biology V, Calfiornia Institute for Regenerative Medicine
• Klingenstein Fellowship in Neuroscience
• Alfred P. Sloan Research Fellowship
• Gabilan Junior Faculty Fellowship, Stanford University
• Mechanisms of Illness, Chronic Fatigue Initiative
• Michael J. Fox Foundation Grant Target Validation Spring 2013
• William and Bernice E. Bumpus Foundation Innovation Award
• NIH Pathway to Independence (K99/R00), NINDS
• Shurl and Kay Curci Foundation
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