Selected Reviews
1) Sun N, Lee A, Wu JC. Long term non-invasive imaging of embryonic stem cells using reporter genes. Nature Protocols 2009;4(8):1192-201 PMID: 19617890. PMCID: 3683546
2) Chen IY, Wu JC. Cardiovascular molecular imaging: focus on clinical translation. Circulation 2011;123(4):425-43. PMID: 21282520. PMCID: 3073678
3) Narsinh KH, Jia F, Robbins RC, Kay MA, Longaker MT, Wu JC. Generation of adult human induced pluripotent stem cells using non-viral minicircle DNA vectors. Nature Protocols 2011;6(1):78-88. PMID: 21212777. PMCID: 3657506
4) Buxton DB, Antman M, Danthi N, Dilsizian V, Fayad ZA, Garcia MJ, Jaff MR, Klimas M, Libby P, Nahrendorf M, Sinusas AJ, Wickline SA, Wu JC, Bonow RO, Weissleder R. Report of the National Heart, Lung, and Blood Institute working group on translation of cardiovascular molecular imaging. Circulation 2011;123(19):2157-63. PMID: 21576680. PMCID: 3119488
5) Narsinh K, Narsinh KH, Wu JC. Derivation of human induced pluripotent stem cells for cardiovascular disease modeling. Circulation Research 2011;108(9):1146-56. PMID: 21527744. PMCID: 3098466
6) Nguyen PK, Lan F, Wang Y, Wu JC. Imaging: guiding the clinical translation of cardiac stem cell therapy. Circulation Research 2011;109(8):962-979. PMID 21960727. PMCID: 3206967
7) Burridge PW, Keller G, Gold JD, Wu JC. Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Cell Stem Cell 2012;10(1):16-28. PMID: 22226352. PMCID: 3255078
8) Pearl JI, Kean LS, Davis MM, Wu JC. Pluripotent stem cells: immune to the immune system. Science Translational Medicine 2012;4(164):164ps25. PMID: 23241742. PMCID: 3638038
9) Sanchez-Freire V, Ebert AD, Kalisky T, Quake SR, Wu JC. Microfluidic single cell real-time PCR for comparative analysis of gene expression patterns. Nature Protocols 2012;7(5):829-838. PMID: 22481529. PMCID: 3657501
10) de Almeida PE, Ransohoff JD, Nahid A, Wu JC. Immunogenicity of pluripotent stem cells and their derivatives. Circulation Research 2013;112(3):549-561. PMID: 23371903. PMCID: 3638957
11) Lee AS, Tang C, Rao MS, Weissman IL, Wu JC. Tumorigenicity as a clinical hurdle for pluripotent stem cells. Nature Medicine 2013;19(8):998-1004. PMID: 23921754. PMCID: 3967018
12) Churko JM, Mantalas GL, Snyder MP, Wu JC. Overview of high throughput sequencing technologies to elucidate molecular pathways in cardiovascular diseases. Circulation Research 2013;112(12):1613-23. PMID: 23743227. PMCID: 3831009
13) Mordwinkin NM, Lee AS, Wu JC. Patient-specific stem cells and cardiovascular drug discovery. Journal American Medical Association 2013;310:2039-2040. PMID: 24240927. PMCID: 4033311
14) Matsa E, Sallam K, Wu JC. Cardiac stem cell biology: glimpse of the past, present, and future. Circulation Research 2014;114(1):21-7. PMID: 24385505. PMCID: 1012892
15) Nguyen PK, Riegler J, Wu JC. Stem cell imaging: from bench to bedside. Cell Stem Cell 2014;14(4):431-444. PMID: 24702995. PMCID: 4024441
16) Kooreman NG, Ransohoff JD, Wu JC. Tracking gene and cell fate for therapeutic gain. Nature Materials 2014;13(2):106-9. PMID: 24452344. PMCID: 4892936
17) Matsa E, Burridge PW, Wu JC. Human stem cells for modeling heart disease and drug discovery. Science Translational Medicine 2014;6(239):239ps6. PMID: 24898747. PMCID: 4215696
18) Narula J, Chandrashekhar YS, Dilsizian V, Garcia MJ, Kramer CM, Malik S, Ryan T, Sen S, Wu JC. COCATS 4 Task Force 4: Training in Multimodality Imaging. Journal American College Cardiology 2015;65(17):1788-85. PMID: 25777648.
19) Sallam K. Li Y, Sager PT, Houser SR, Wu JC. Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes. Circulation Research 2015;116(12):1989-2004. PMID: 26044252. PMCID: 4676576
20) Karakikes I, Ameen M, Termglinchan V, Wu JC. Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes. Circulation Research 2015;117(1):80-88. PMID: 26089365. PMCID: 4546707
21) Neofytou E, O’Brien CG, Couture LA, Wu JC. Hurdles to clinical translation of human induced pluripotent stem cells. Journal Clinical Investigation 2015;125(7):2551-2557. PMID: 26132109. PMCID: 4563685
22) Burridge PW, Sharm A, Wu JC. Genetic and epigenetic regulation of human cardiac reprogramming and differentiation in regenerative medicine. Annual Review Genetics 2015;49:461-484. PMID: 26631515. PMCID: 4962619
23) Ogle BM, Bursac N, Domian I, Huang NF, Menasché P, Murry CE, Pruitt B, Radisic M, Wu JC, Wu SM, Zhang J, Zimmermann WH, Vunjak-Novakovic G. Distilling complexity to advance cardiac tissue engineering. Science Translational Medicine 2016;8(342):342ps13. PMID: 27280684. PMCID: 4959426
24) Wilson KD, Wu JC. Induced pluripotent stem cells. Journal American Medical Association 2015;313(16):1613-4. PMID: 25919522
25) Sayed N, Liu C, Wu JC. Translation of human iPSCs: From clinical trial in a dish to precision medicine. Journal American College of Cardiology 2016;67(18):2161-76. PMID: 27151349. PMCID: 5086255
26) Chen IY, Matsa E, Wu JC. Induced pluripotent stem cells: at the heart of cardiovascular precision medicine. Nature Review Cardiology 2016;13(6):333-49. PMID: 27009425. PMCID: 5917945
27) Lee WH, Nguyen PK, Fleischmann D, Wu JC. DNA damage-associated biomarkers in studying individual sensitivity to low-dose radiation from cardiovascular imaging. European Heart Journal 2016;37(40):3075-3080. PMID: 27272147. PMCID: 6279211
28) Gurvitz M, Burns KM, Brindis R, Broberg CS, Daniels CJ, Fuller SM, Honein MA, Khairy P, Kuehl KS, Landzberg MJ, Mahle WT, Mann DL, Marelli A, Newburger JW, Pearson GD, Starling RC, Tringali GR, Valente AM, Wu JC, Califf RM. Emerging research directions in adult congenital heart disease: a report from an NHLBI/ACHA working group. Journal American College Cardiology 2016;67(16):1956-64. PMID: 27102511. PMCID: 4846980
29) Matsa E, Ahrens JH, Wu JC. Human induced pluripotent stem cells as a platform for personalized and precision cardiovascular medicine. Physiological Reviews 2016;96(3):1093-126. PMID: 27335446. PMCID: 6345246
30) Nguyen PK, Rhee JW, Wu JC. Adult stem cell therapy and heart failure, 2000 to 2016: a systematic review. JAMA Cardiology 2016;1(7):831-841. PMID: 27557438. PMCID: 5349705
31) Nguyen PK, Neofytou E, Rhee JW, Wu JC. Potential strategies for addressing the major clinical hurdles facing stem cell therapy. JAMA Cardiology 2016;1(8):953-962. PMID: 27579998. PMCID: 5378463
32) Seeger T, Porteus M, Wu JC. Genome editing in cardiovascular biology. Circulation Research 2017;120(5):778-780. PMID: 28254802. PMCID: 5394983
33) Fernández-Avilés F, Sanz-Ruiz R, Climent AM, Badimon L, Bolli R, Charron D, Fuster V, Janssens S, Kastrup J, Kim HS, Lüscher TF, Martin JF, Menasché P, Simari RD, Stone GW, Terzic A, Willerson JT, Wu JC. TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes) Writing Group. Global position paper on cardiovascular regenerative medicine: Scientific statement of the transnational alliance for regenerative therapies in cardiovascular syndromes (TACTICS) international group for the comprehensive cardiovascular application of rege. European Heart Journal 2017;38(33):2532-2546. PMID: 28575280. PMCID: 5837698
34) Zhang J, Li H, Trounson A, Wu JC, Nioi P. Combining hiPSCs and human genetics: major applications in drug development. Cell Stem Cell 2017;21(2):161-165. PMID: 28777942.
35) Mahmoudi M, Yu M, Serpooshan V, Wu JC, Langer R, Lee RT, Karp JM, Farokhzad OC. Multiscale technologies for treatment of ischemic cardiomyopathy. Nature Nanotechnology 2017;12(9):845-855. PMID: 28875984. PMCID: 5717755
36) Magdy T, Schuldt AJT, Wu JC, Bernstein D, Burridge PW. Human induced pluripotent stem cell (hiPSC)-derived cells to assess drug cardiotoxicity: opportunities and problems. Annual Review Pharmacology Toxicology 2018;58:83-103. PMID: 28992430. PMCID: 7386286
37) Garg P, Garg V, Shrestha R, Sanguinetti MC, Kamp TJ, Wu JC. Human induced pluripotent stem cell-derived cardiomyocytes as models for cardiac channelopathies: a primer for non-electrophysiologists. Circulation Research 2018;123(2):224-243. PMID: 29976690. PMCID: 6136439
38) Sharma A, McKeithan WL, Serrano R, Kitani T, Burridge PW, Del Álamo JC, Mercola M, Wu JC. Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity. Nature Protocols 2018;13(12):3018-3041. PMID: 30413796. PMCID: 1012804
39) Chen H, Zhang A, Wu JC. Harnessing cell pluripotency for cardiovascular regenerative medicine. Nature Biomedical Engineering 2018;2(6):392-398. PMID: 31011193.
40) Lau E, Paik DT, Wu JC. Systems-wide approaches in induced pluripotent stem cell models. Annual Review Pathology 2019;14:395-419. PMID: 30379619. PMCID: 1012802
41) Stack JP, Moslehi J, Sayed N, Wu JC. Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it? European Hear Journal 2019;40(22):1764-1770. PMID: 29377985. PMCID: 1012807
42) Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of life sciences and engineering in understanding and treating heart failure. Circulation Research 2019;124(1):161-169. PMID: 30605412. PMCID: 6350935
43) Wu JC, Woo YJ, Mayerle M, Harrington RA, Quertermous T. Stanford Cardiovascular Institute. Circulation Research 2019;124(10):1420-1424. PMID: 31070998.
44) Pang L, Sager P, Yang X, Shi H, Sannajust F, Brock M, Wu JC, Abi-Gerges N, Lyn-Cook B, Berridge BR, Stockbridge N. Workshop Report: FDA Workshop on improving cardiotoxicity assessment with human-relevant platforms. Circulation Research 2019;125(9):855-867. PMID: 31600125. PMCID: 6788760
45) Gintant G, Burridge P, Gepstein L, Harding S, Herron T, Hong C, Jalife J, Wu JC. Use of human induced pluripotent stem cell-derived cardiomyocytes in preclinical cancer drug cardiotoxicity testing: a scientific statement from the American Heart Association. Circulation Research 2019;125(10):e75-e92. PMID: 31533542. PMCID: 7398423
46) Wu JC, Garg P, Yoshida Y, Yamanaka S, Gepstein L, Hulot JS, Knollmann BC, Schwartz PJ. Towards precision medicine with human iPSCs for cardiac channelopathies. Circulation Research 2019;125(6):653-658. PMID: 31465267.
47) Paik DT, Chandy M, Wu JC. Patient and disease-specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics. Pharmacological Reviews 2020;72(1):320-342. PMID: 31871214. PMCID: 6934989.
48) Paik DT, Cho S, Tian L, Chang HY, Wu JC. Single-cell RNA sequencing in cardiovascular development, disease and medicine. Nature Review Cardiology 2020;17(8):457-473. PMID: 32231331. PMCID: 7528042
49) Nishiga M, Wang DW, Han Y, Lewis DB, Wu JC. COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives. Nature Review Cardiology 2020; 17(9):543-558. PMID: 32690910. PMCID: 7370876
50) Figtree GA, Broadfoot K, Casadei B, Califf R, Crea F, Drummond GR, Freedman JE, Guzik TJ, Harrison D, Hausenloy DJ, Hill JA, Januzzi JL, Kingwell BA, Lam CSP, MacRae CA, Misselwitz F, Miura T, Ritchie RH, Tomaszewski M, Wu JC, Xiao J, Zannad F. A call to action for new global approaches to cardiovascular disease drug solutions. Circulation 2021:144(2):159-169. PMID: 33876947.
51) Shen M, Quertermous T, Fischbein MP, Wu JC. Generation of vascular smooth muscle cells from induced pluripotent stem cells: methods, applications, and considerations. Circulation Research 2021;128(5):670-686. PMID: 33818124. PMCID: 10817206
52) Zhang J, Bolli R, Garry DJ, Marbán E, Menasché P, Zimmermann WH, Kamp TJ, Wu JC, Dzau VJ. Basic and translational research in cardiac repair and regeneration: JACC State-of-the-Art Review. Journal American College Cardiology 2021;78(21):2092-2105. PMID: 34794691. PMCID: 9116459
53) McNally EM, Elkind MSV, Benjamin IJ, Chung MK, Dillon GH, Hernandez AF, Ibeh C, Lloyd-Jones DM, McCullough LD, Wold LE, Wright DR, Wu JC; American Heart Association. Impact of the COVID-19 pandemic on cardiovascular science: anticipating problems and potential solutions: a presidential advisory from the American Heart Association. Circulation 2021;144(23):e461-e471. 34719260. PMCID: 10227717
54) Zhang J, Bolli R, Garry DJ, Marbán E, Menasché P, Zimmermann WH, Kamp TJ, Wu JC, Dzau VJ. Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review. Journal American College Cardiology 2021;78(21):2092-2105. PMID: 34794691. PMCID: 9116459
55) Nishiga M, Liu C, Qi LS, Wu JC. The use of new CRISPR tools in cardiovascular research and medicine. Nature Review Cardiology 2022; doi: 10.1038/s41569-021-00669-3. PMID: 35145236. PMCID: 10283450
56) Wilcox NS, Rotz SJ, Mullen M, Song EJ, Ky Hamilton B, Moslehi J, Armenian SH, Wu JC, Rhee JW, Ky B. Sex-specific cardiovascular risks of cancer and its therapies. Circulation Research 2022;130(4):632-651. PMID 35175846. PMCID: 8915444
57) Zhang A, Xing L, Zou J, Wu JC. Shifting machine learning for healthcare from development to deployment and from models to data. Nature Biomedical Engineering 2022;6(12):1330-1345. PMID: 35788685.
58) Kim H, Kamm RD, Vunjak-Novakovic G, Wu JC. Progress in multicellular human cardiac organoids for clinical applications. Cell Stem Cell 2022;29(4):503-514. PMID: 35395186. PMCID: 9352318
59) Wold LE, Tarran R, Crotty Alexander LE, Hamburg NM, Kheradmand F, St Helen G, Wu JC. Cardiopulmonary consequences of vaping in adolescents: a scientific statement from the American Heart Association. Circulation Research 2022;131(3):e70-e82. PMID: 35726609.
60) Thomas D, Choi S, Alamana C, Parker KK, Wu JC. Cellular and engineered organoids for cardiovascular models. Circulation Research 2022;130(12):1780-1802. PMID: 35679369.
61) Cho S, Discher DE, Leong KW, Vunjak-Novakovic G, Wu JC. Challenges and opportunities for the next generation of cardiovascular tissue engineering. Nature Methods 2022;19(9):1064-1071. PMID: 36064773.
62) Tan WLW, Seow WQ, Zhang A, Rhee S, Wong WH, Greenleaf WJ, Wu JC. Current and future perspectives of single-cell multi-omics technologies in cardiovascular research. Nature Cardiovascular Research 2023;2(1):20-34. PMID: 39196210.
63) Zhang A, Wu Z, Wu E, Wu M, Snyder MP, Zou J, Wu JC. Leveraging physiology and artificial intelligence to deliver advancements in healthcare. Physiological Review 2023;103(4):2423-2450. PMID: 37104717. PMCID: 10390055
64) Ahmed SM, Shivnaraine RV, Wu JC. FDA Modernization Act 2.0 paves the way to computational biology and clinical trials in a dish. Circulation 2023;148(4):309-311. PMID: 37486997. PMCID: 10902210
65) Zushin PH, Mukherjee S, Wu JC. FDA Modernization Act 2.0: transitioning beyond animal models with human cells, organoids, and AI/ML-based approaches. Journal Clinical Investigation 2023;133(21):e175824. PMID: 37909337. PMCID: 10617761
66) Chandy M, Nishiga M, Wei TT, Hamburg NM, Nadeau K, Wu JC. Adverse impact of cannabis on human health. Annual Review Medicine 2024;75:353-367. PMID: 37582489. PMCID: 10947506
67) Caudal A, Snyder MP, Wu JC. Harnessing human genetics and stem cells for precision cardiovascular medicine. Cell Genomics 2024;4(2):100445. PMID: 38359791. PMCID: 10879032
68) Jahng JWS, Little MP, No HJ, Loo BW Jr, Wu JC. Consequences of ionizing radiation exposure to the cardiovascular system. Nature Review Cardiology 2024;21(12):880-898. PMID: 38987578.
69) Wu X, Swanson K, Yildirim Z, Liu W, Liao R, Wu JC. Clinical trials in-a-dish for cardiovascular medicine. European Heart Journal 2024;45(40):4275-4290. PMID: 39270727. PMCID: 11491156
70) Pang PD, Ahmed SM, Nishiga M, Stockbridge NL, Wu JC. Tackling the challenges of new approach methods for predicting drug effects from model systems. Nature Review Drug Discovery 2024;23(8):565-566. PMID: 38750208. PMCID: 11482555
71) Chandy M, Jimenez-Tellez N, Wu JC. The relationship between cannabis and cardiovascular disease: clearing the haze. Nature Review Cardiology 2025. Online ahead of print. PMID: 39849111.
72) Zhang K, Yang X, Wang Y, Yu Y, Huang N, Li G, Li X, Wu JC, Yang S. Artificial intelligence in drug development. Nature Medicine 2025;31(1):45-59. PMID: 39833407.
73) Zushin PH, Wu JC. Evaluating the benefits of the early use of GLP-1 receptor agonists. Lancet 2025;405(10474):181-183. PMID: 39547251. PMCID: 11921982