Selected Papers
1) Wu JC, Inubushi M, Sundaresan G, Schelbert HR, Gambhir SS. Positron emission tomography imaging of cardiac reporter gene expression in living rats. Circulation 2002;106:180-183. PMID: 12105155. PMCID: 4154807 (*Journal cover)
2) Wu JC, Inubushi M, Sundaresan G, Schelbert HR, Gambhir SS. Optical imaging of cardiac reporter gene expression in living rats. Circulation 2002;105:1631-1634. PMID: 11940538
3) Wu JC, Chen IY, Sundaresan G, Min JJ, De A, Qiao JH, Fishbein MC, Gambhir SS. Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography. Circulation 2003;108:1302-1305. PMID: 12963637. PMCID: 4154815 (*Journal cover)
4) Wu JC, Chen IY, Wang Y, Tseng JR, Chhabra A, Salek M, Min JJ, Fishbein MC, Crystal R, Gambhir SS. Molecular imaging of the kinetics of VEGF gene expression in ischemic myocardium. Circulation 2004;110:685-691. PMID: 15302807. PMCID: 4154794
5) Cao F, Lin S, Xie X, Ray P, Patel M, Zhang X, Drukker M, Dylla SJ, Connolly AJ, Chen X, Weissman IL, Gambhir SS, Wu JC. In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation 2006;113(7):1005-14. PMID: 16476845. PMCID: 4701384 (*Best Basic Science paper in Circulation 2006)
6) Li Z, Wu JC, Sheikh AY, Kraft D, Cao F, Xie X, Patel M, Gambhir SS, Robbins RC, Cooke JP, Wu JC. Differentiation, survival, and function of embryonic stem cell-derived endothelial cells. Circulation 2007;116:I46-I54. PMID: 17846325. PMCID: 3657509
7) van der Bogt K, Sheikh AY, Schrepfer S, Hoyt G, Cao F, Ransohoff K, Swijnenburg RJ, Pearl J, Fischbein M, Contag CH, Robbins RC, Wu JC. Comparison of different adult stem cell types for treatment of myocardial ischemia. Circulation 2008;118:S121-S129. PMID: 18824743. PMCID: 3657517
8) Swijnenburg RJ, Schrepfer S, Govaert JA, Cao F, Ransohoff K, Shiekh AY, Haddad M, Connolly AJ, Davis MM, Robbins RC, Wu JC. Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts. Proceedings National Academy of Science 2008;105(35):12991-2996. PMID: 18728188. PMCID: 2529073 (*Editorial in Cell Stem Cell by A Chidgey & R Boyd)
9) Li Z, Lee A, Huang M, Chun H, Chung J, Chu P, Hoyt G, Yang P, Rosenberg J, Robbins RC, Wu JC*. Imaging survival and function of transplanted cardiac resident stem cells. Journal American College Cardiology 2009;53(14): 1229-40. PMID: 19341866. PMCID: 2878762 (*JACC William Parmley Prize)
10) Huang M, Chen ZY, Hu S, Jia F, Li Z, Hoyt G, Robbins RC, Kay M, Wu JC. Novel minicircle vector for gene therapy in murine myocardial infarction. Circulation 2009;120:S230-S237. PMID: 19752373. PMCID: 3163107
11) Sun N, Panetta NJ, Gupta DM, Wilson KD, Lee A, Jia F, Hu S, Cherry AM, Robbins RC, Longaker MT, Wu JC. Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proceedings National Academy of Science 2009;106(37):15720-5. PMID: 19805220. PMCID: 2739869
12) Hu S, Huang M, Li Z, Jia F, Ghosh Z, Lijkwan MA, Fasanaro P, Sun N, Wang X, Martelli F, Robbins RC, Wu JC. MicroRNA-210 as a novel therapy for treatment of ischemic heart disease. Circulation 2010;122:S124-S31. PMID: 20837903. PMCID: 2952325
13) Hu S, Huang M, Nguyen PK, Gong Y, Li Z, Jia F, Lan F, Liu J, Nag D, Robbins RC, Wu JC. Novel microRNA prosurvival cocktail for improving engraftment and function of cardiac progenitor cell transplantation. Circulation 2011;124:S27-S34. PMID: 21911815. PMCID: 3181082
14) Pearl JI, Lee A, Leveson-Gower DB, Sun N, Ghosh Z, Lan F, Ransohoff J, Negrin RS, Davis MM, Wu JC. Short-term blockade of leukocyte costimulatory molecules promotes engraftment of embryonic and induced pluripotent stem cells. Cell Stem Cell 2011;8(3):309-17. PMID: 21362570. PMCID: 3061351 (*Editorial by MF Pera)
15) Tang C, Lee AS, Peter-Volkmer J, Sahoo D, Mosley A, van de Rijn M, Inlay MA, Ardehali R, Wu JC, Weissman IL, Drukker M. Removal of residual teratoma-forming cells via a surface antibody panel ensures transplantation safety of human pluripotent stem cell derivatives. Nature Biotechnology 2011;29(9):829-834. PMID: 21841799. PMCID: 3537836 (*Journal cover)
16) Narsinh KH, Sun N, Sanchez-Freire V, Lee AS, Almeida P, Hu S, Jan T, Wilson KD, Leong D, Rosenberg J, Yao M, Wu JC. Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. Journal Clinical Investigation 2011;121(3):1217-21. PMID: 21317531. PMCID: 3049389
17) Huang M, Nguyen PK, Jia F, Hu S, Gong Y, de Almeida PE, Wang L, Nag D, Kay MA, Giaccia AJ, Robbins RC, Wu JC. Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction. Circulation 2011;124:S46-S54. PMID: 21911818. PMCID: 3181087
18) Gu M, Nguyen P, Lee AS, Xu D, Hu S, Plews JR, Han L, Huber BC, Lee WH, Gong Y, de Almeida PE, Lyons J, Ikeno F, Pacharinsak C, Connolly AJ, Gambhir SS, Robbins RC, Longaker MT, Wu JC. Microfluidic single cell analysis show porcine induced pluripotent stem cell-derived endothelial cells improve myocardial function by paracrine activation. Circulation Research 2012;111:882-893. PMID: 22821929. PMCID: 3473073 (*Journal cover & 2013 Best Manuscript Award)
19) Wang Y, Zhang WY, Hu S, Lan F, Lee AS, Huber B, Lisowski L, Liang P, Huang M, de Almeida PE, Won JH, Sun N, Kay MA, Urnov FD, Wu JC. Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nuclease for cellular imaging. Circulation Research 2012;111(12):1494-503. PMID: 22967807. PMCID: 3518748 (*Editorial by G Courties & M Nahrendorf)
20) Sun N, Yazawa M, Liu J, Han L, Sanchez-Freire V, Abilez OJ, Navarrete EG, Hu S, Wang L, Lee A, Pavlovic A, Lin S, Chen R, Hajjar RJ, Snyder MP, Dolmetsch RE, Butte MJ, Ashley EA, Longaker MT, Robbins RC, Wu JC. Patient-specific induced pluripotent stem cell as a model for familial dilated cardiomyopathy. Science Translational Medicine 2012;4:130ra47. PMID: 22517884. PMCID: 3657516 (*Journal cover)
21) Lan F, Liu J, Narsinh K, Hu S, Han L, Lee A, Karow M, Nguyen PK, Nag D, Calos MP, Robbins RC, Wu JC. Safe genetic modification of cardiac stem cells by site-specific integration. Circulation 2012;126:S20-S28. PMID: 22965984. PMCID: 3481839
22) Lan F, Lee AS, Liang P, Sanchez-Freire V, Nguyen PK, Wang L, Han L, Yen M, Wang Y, Sun N, Abilez OJ, Navarrete EG, Simons CS, Wheeler M, Pruitt B, Lewis R, Yamaguchi Y, Ashley EA, Bers DB, Robbins RC, Longaker MT, Wu JC. Abnormal calcium handling properties underlie pathogenesis of familial hypertrophic cardiomyopathy in patient-specific induced pluripotent stem cells. Cell Stem Cell 2013;12(1):101-13. PMID: 23290139. PMCID: 3638033 (*Faculty 1000 “Must Read
23) Vrtovec B, Poglajen G, Lezaic L, Sever M, Cernelc P, Socan A, Schrepfer S, Torre-Amione G, Haddad F, Wu JC. Effects of intracoronary CD34+ stem cell transplantation in non-ischemic dilated cardiomyopathy patients: 5-year follow up. Circulation Research 2013;112:165-173. PMID: 23065358 (*Journal cover)
24) Dey D, Han L, Bauer M, Sanada F, Oikonomopoulos A, Hosoda T, Unno K, De Almeida P, Leri A, Wu JC. Dissecting the molecular relationship among various cardiogenic progenitor cells. Circulation Research 2013;112(9):1253-62. PMID: 23463815. PMCID: 3657513 (*Journal cover)
25) Liang P, Lan F, Lee AS, Gong T, Sanchez-Freire V, Wang Y, Diecke S, Sallam K, Knowles JW, Nguyen PK, Wang PJ, Bers DM, Robbins RC, Wu JC. Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease specific patterns of cardiotoxicity. Circulation 2013;127:1677-1691. PMID: 23519760. PMCID: 3870148 (*Editorial by D Roden & C Hong; Best Basic Science Paper in Circulation)
26) Vrtovec B, Poglajen G, Lezaic L, Sever M, Socan A, Domanovic D, Cernelc P, Torre-Amione G, Haddad F, Wu JC. Comparison of transendocardial and intracoronary CD34+ cell transplantation in patients with nonischemic dilated cardiomyopathy. Circulation 2013;128:S42-S49. PMID: 24030420.
27) Lister R, Mukamel EA, Nery JR, Urich M, Puddifoot CA, Johnson ND, Lucero J, Huang Y, Dwork AJ, Schultz MD, Yu M, Tonti-Filippini J, Pastor WA, Heyne H, Hu S, Wu JC, Rao A, Esteller M, He C, Haghighi FG, Sejowski TJ, Behrens MM, Ecker JR. Global epigenomic reconfiguration during mammalian brain development. Science 2013;341(6146):1237905. PMID: 23828890. PMCID: 3785061
28) Navarrete EG, Liang P, Lan F, Sanchez-Freire V, Simmons C, Gong T, Sharma A, Burridge PW, Patlolla B, Lee AS, Wu H, Beygui RE, Wu SM, Robbins RC, Bers DM, Wu JC. Screening adverse drug-induced arrhythmia events using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation 2013;128:S3-S13. PMID: 24030418. PMCID: 3855862
29) Riegler J, Gillich A, Shen Q, Gold JD, Wu JC. Cardiac tissue slice transplantation as a model to assess tissue-engineered graft thickness. Circulation 2014;130:S77-S86. PMID: 25200059. PMCID: 4353847
30) Wang Y, Liang P, Lan F, Wu H, Lisowski L, Gu M, Hu S, Kay MA, Urnov FD, Shinnawi R, Gold JD, Gepstein L, Wu JC. Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing. Journal American College Cardiology 2014;64(5):451-459. PMID: 25082577. PMCID: 4149735
31) De Almeida PE, Meyer EH, Kooreman NG, Diecke S, Dey D, Sanchez-Freire V, Hu S, Ebert A, Odegaard J, Mordwinkin N, Brouwer TP, Lo D, Montoro D, Longaker MT, Negrin RS, Wu JC. Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance. Nature Communication 2014;5,3903. PMID: 24875164. PMCID: 4075468
32) Sharma A, Marceau CD, Hamaguchi R, Burridge P, Rajarajan K, Churko J, Wu H, Sallam K, Matsa E, Sturzu A, Che Y, Ebert A, Diecke S, Liang P, Red-Horse K, Carette JE, Wu SM, Wu JC. Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform. Circulation Research 2014;115:556-566. PMID: 25015077. PMCID: 4149868 (*Journal cover)
33) Asimaki A, Kapoor S, Plovie E, Karin Arndt A, Adams E, Liu ZZ, James CA, Judge DP, Calkins H, Churko J, Wu JC, MacRae CA, Kleber AG, Saffitz JE. Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy. Science Translational Medicine 2014:6(240):p240ra74. PMID: 24920660. PMCID: 4471875
34) Sanchez-Freire V, Lee AS, Hu S, Abilez OJ, Liang P, Lan F, Huber BC, Ong SG, Hong WX, Huang M, Wu JC. Effect of donor cell source on differentiation and function of cardiac induced pluripotent stem cells. Journal American College Cardiology 2014;64(5):436-448. PMID: 25082575. PMCID: 4134946
35) Ong SG, Lee WH, Huang M, Dey D, Kodo K, Sanchez-Freire V, Gold JC, Wu JC. Cross talk of combined gene and cell therapy in ischemic heart disease: role of exosomal microRNA transfer. Circulation 2014;130:S60-S69. PMID: 25200057. PMCID: 4862832
36) Burridge PW, Matsa E, Shukla P, Lin ZC, Churko JM, Ebert AD, Lan F, Diecke S, Huber B, Mordwinkin NM, Plews JR, Abilez OJ, Cui B, Gold JD, Wu JC. Chemically defined and small molecule-based generation of human cardiomyocytes. Nature Methods 2014;11(8):855-860. PMID: 24930130.
37) Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, de Almeida P, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC. Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Science Translational Medicine 2014;6:255ra130. PMID: 25253673. PMCID: 4215699
38) Gu M, Mordwinkin NM, Kooreman NG, Lee J, Wu H, Hu S, Churko JM, Diecke S, Burridge PW, He C, Barron FE, Ong SG, Gold JD, Wu JC. Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism. European Heart Journal 2015;36(13):806-16. PMID: 25368203. PMCID: 4381134
39) Karakikes I, Stillitano F, Nonnenmacher M, Tzimas C, Sanoudou D, Termglinchan V, Kong CW, Rushing S, Hansen J, Ceholski D, Kolokathis F, Kremastinos D, Katoulis A, Ren L, Cohen N, Gho JM, Tsiapras D, Vink A, Wu JC, Asselbergs FW, Li RA, Hulot JS, Kranias EG, Hajjar RJ. Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy. Nature Communication 2015;6: 6955. PMID: 25923014. PMCID: 4421839
40) Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko J, Sallam K, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC. Epigenetic modifications of phosphodiesterase contribute to compromised β-adrenergic signaling during the pathogenesis of DCM-specific iPSC-derived cardiomyocytes. Cell Stem Cell 2015;17(1):89-100. PMID: 26095046. PMCID: 4546705
41) Wilson KD, Shen P, Fung E, Karakikes I, Zhang A, InanlooRahatloo K, Odegaard J, Sallam K, Davis RW, Lui G, Ashley E, Scharfe C, Wu JC. A rapid, high-quality, cost-effective, comprehensive and expandable targeted next-generation sequencing assay for inherited heart diseases. Circulation Research 2015;117(7):603-611. PMID: 26265630. PMCID: 4568077 (*Journal cover)
42) Riegler J, Tiburcy M, Ebert A, Tzatzalos E, Raaz U, Abilez OJ, Shen Q, Kooreman NG, Neofytou E, Chen V, Wang M, Meyer T, Tsao PS, Connolly AJ, Couture LA, Gold JD, Zimmermann WH, Wu JC. Human engineered heart muscles engraft and survive long-term in a rodent myocardial infarction model. Circulation Research 2015;117(8):720-30. PMID: 26291556. PMCID: 4679370
43) Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmstrom A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC. Human induced pluripotent stem-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. Nature Medicine 2016;22(5):547-56. PMID: 27089514. PMCID: 5086256
44) Chang AC, Ong SG, LaGory EL, Kraft PE, Giaccia AJ, Wu JC, Blau HM. Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy. Proceedings National Academy of Science 2016;113(46):13120-13125. PMID: 27799523. PMCID: 5135315
45) Liang P, Sallam K, Wu H, Li Y, Itzhaki I, Garg P, Zhang Y, Termglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churko J, Hu S, Sharma A, Scheinman MM, Bers DM, Wu JC. Patient-specific and genome-edited induced pluripotent stem cell-derived cardiomyocytes elucidate single cell phenotype of Brugada syndrome. Journal American College of Cardiology 2016;68(19):2086-2096. PMID: 27810048. PMCID: 5373649 (*JACC William Parmley Prize)
46) Matsa E, Burridge PW, Yu KH, Ahrens JH, Termglinchan V, Wu H, Liu C, Shukla P, Sayed N, Churko JM, Shao N, Woo NA, Chao AS, Gold JD, Karakikes I, Snyder MP, Wu JC. Transcriptome profiling of patient-specific human iPSC-cardiomyocytes predicts individual drug safety and efficacy responses in vitro. Cell Stem Cell 2016;19(3):311-325. PMID: 27545504. PMCID: 5087997
47) Davis J, Davis LC, Correll RN, Makarewich CA, Schwanekamp JA, Moussavi-Harami F, Wang D, York AJ, Wu H, Houser SR, Seidman CE, Seidman JG, Regnier M, Metzger JM, Wu JC, Molkentin JD. A tension-based model distinguishes hypertrophic versus dilated cardiomyopathy. Cell 2016;165(5):1147-59. PMID: 27114035. PMCID: 4874838
48) Kodo K, Ong SG, Jahanbani F, Termglinchan V, Hirono K, InanlooRahatloo K, Ebert AD, Shukla P, Abilez OJ, Churko JM, Karakikes I, Jung G, Ichida F, Wu SM, Snyder MP, Bernstein D, Wu JC. iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy. Nature Cell Biology 2016;18(10):1031-42. PMID: 27642787. PMCID: 5042877
49) Tiburcy M, Hudson JE, Balfanz P, Schlick SF, Meyer T, Chang Liao ML, Levent E, Raad F, Zeidler S, Wingender E, Riegler J, Wang M, Gold JD, Kehat I, Wettwer E, Ravens U, Dierickx P, van Laake L, Goumans MJ, Khadjeh S, Toischer K, Hasenfuss G, Couture LA, Unger A, Linke WA, Araki T, Neel B, Keller G, Gepstein L, Wu JC, Zimmermann WH. Defined engineered human myocardium with advanced maturation for applications in heart failure modelling and repair. Circulation 2017;135(19):1832-1847. PMID: 28167635. PMCID: 5501412
50) Karakikes I, Termglinchan V, Cepeda DA, Lee J, Diecke S, Hendel A, Itzhaki I, Ameen M, Shrestha R, Wu H, Ma N, Shao NY, Seeger T, Woo NA, Wilson KD, Matsa E, Porteus MH, Sebastiano V, Wu JC. A comprehensive TALEN-based knockout library for generating human induced pluripotent stem cell-based models for cardiovascular diseases. Circulation Research 2017;120(10):1561-1571. PMID: 28246128. PMCID: 5429194 (*Journal cover and Best Manuscript Award in Circulation Research)
51) Gu M, Shao NY, Sa S, Li D, Termglinchan V, Ameen M, Karakikes I, Sosa G, Grubert F, Lee J, Cao A, Taylor S, Ma Y, Zhao Z, Chappell J, Hamid R, Austin ED, Gold JD, Wu JC, Snyder MP, Rabinovitch M. Patient-specific iPSC-derived endothelial cells uncover pathways that protect against pulmonary hypertension in BMPR2 mutation carriers. Cell Stem Cell 2017;20(4):490-504. PMID: 28017794. PMCID: 5500296
52) Chao MP, Gentles AJ, Chatterjee S, Lan F, Reinisch A, Corces MR, Xavy S, Shen J, Haag D, Chanda S, Sinha R, Morganti RM, Nishimura T, Ameen M, Wu H, Wernig M, Wu JC, Majeti R. Human AML-iPSCs reacquire leukemic properties after differentiation and model clonal variation of disease. Cell Stem Cell 2017;20(3):329-344. PMID: 28089908. PMCID: 5508733
53) Cao Y, Hjort M, Chen H, Birey F, Leal-Ortiz SA, Han CM, Santiago JG, Paşca SP, Wu JC, Melosh NA. Nondestructive nanostraw intracellular sampling for longitudinal cell monitoring. Proceedings National Academy of Science 2017;114(10):E1866-E1874. PMID: 28223521. PMCID: 5347600
54) Kooreman NG, de Almeida PE, Stack JP, Nelakanti RV, Diecke S, Shao NY, Swijnenburg RJ, Sanchez-Freire V, Matsa E, Liu C, Connolly AJ, Hamming JF, Quax PHA, Brehm MA, Greiner DL, Shultz LD, Wu JC. Alloimmune responses of humanized mice to human pluripotent stem cell therapeutics. Cell Reports 2017;20(8):1978-1990. PMID: 28834758. PMCID: 5573767
55) Sharma A, Burridge PW, McKeithan WL, Serrano R, Shukla P, Sayed N, Churko JM, Kitani T, Wu H, Holmström A, Matsa E, Zhang Y, Kumar A, Fan AC, del Álamo JC, Wu SM, Moslehi JJ, Mercola M, Wu JC. High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Science Translational Medicine 2017;9(377):eaaf2584. PMID: 28202772. PMCID: 5409837
56) Liu Q, Jiang C, Xu J, Zhao M, Van Bortle K, Cheng X, Wang G, Chang HY, Wu JC, Snyder MP. Genome-wide temporal profiling of transcriptome and open-chromatin of early cardiomyocyte differentiation derived from hiPSCs and hESCs. Circulation Research 2017;121(4):376-391. PMID: 28663367. PMCID: 5576565
57) Li X, Kuznetsova T, Cauwenberghs N, Wheeler M, Maecker H, Wu JC, Haddad F, Dai H. Autoantibody profiling on a plasmonic nano-gold chip for the early detection of hypertensive heart disease. Proceedings National Academy of Science 2017;114(27):7089-7094. PMID: 28630342. PMCID: 5502602
58) Zhao M, Shao NY, Hu S, Ma N, Srinivasan R, Jahanbani F, Lee J, Zhang SL, Snyder MP, Wu JC. Cell Type-specific chromatin signatures underline regulatory DNA elements in human induced pluripotent stem cells and somatic cells. Circulation Research 2017;121:1237-1250. PMID: 29030344. PMCID: 5773062
59) Zhao MT, Chen H, Liu Q, Shao NY, Sayed N, Wo HT, Zhang JZ, Ong SG, Liu C, Kim Y, Yang H, Chour T, Ma H, Gutierrez NM, Karakikes I, Mitalipov S, Snyder MP, Wu JC. Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs. Proceedings National Academy of Science 2017;114(52):E11111-E11120. PMID: 29203658. PMCID: 57448177
60) Rhee S, Chung JI, King DA, D'amato G, Paik DT, Duan A, Chang A, Nagelberg D, Sharma B, Jeong Y, Diehn M, Wu JC, Morrison AJ, Red-Horse K. Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease. Nature Communication 2018;9(1):368. PMID: 29371594. PMCID: 5785521
61) Churko JM, Lee J, Ameen M, Gu M, Venkatasubramanian M, Diecke S, Sallam K, Im H, Wang G, Gold JD, Salomonis N, Snyder MP, Wu JC. Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods. Nature Biomedical Engineering 2017;1(10):826-837. PMID: 30263871. PMCID: 6155993
62) Lee AS, Inayathullah M, Lijkwan MA, Zhao X, Sun W, Parekh MB, Kooreman N, Malkovskiy AV, Lau E, Qin X, Pothineni VR, Park S, Hong WX, Sanchez-Freire V, Zhang WY, Ebert AD, Chan CK, Nguyen PK, Rajadas J, Wu JC. A novel slow release collagen matrix cross-linked with pro-survival factor analogs promotes stem cell survival for treatment of ischemic cardiovascular disease. Nature Biomedical Engineering 2018;2:104-113. PMID: 29721363. PMCID: 5927627
63) Lee J, Shao NY, Paik DT, Wu H, Guo H, Termglinchan V, Churko JM, Kim Y, Kitani T, Zhao MT, Zhang Y, Wilson KD, Karakikes I, Snyder MP, Wu JC. SETD7 drives cardiac lineage commitment through stage-specific transcriptional activation. Cell Stem Cell 2018;22(3):428-444. PMID: 29499155. PMCID: 5785460
64) Zhao X, Chen H, Xiao D, Yang H, Itzhaki I, Qin X, Chour T, Aguirre A, Lehmann K, Kim Y, Shukla P, Holmstrom A, Zhang JZ, Zhuge Y, Ndoye BC, Zhao M, Neofytou E, Zimmermann WH, Jain M, Wu JC. Comparison of non-human primate vs. human induced pluripotent stem cell-derived cardiomyocytes for treatment of myocardial infarction. Stem Cell Report 2018;10(2):422-435. PMID: 29398480. PMCID: 5830958
65) Ma N, Zhang J, Itzhaki I, Zhang SL, Chen H, Haddad F, Kitani T, Wilson KD, Tian L, Shrestha R, Wu H, Lam CK, Sayed N, Wu JC. Determining the pathogenicity of a genomic variant of uncertain significance using CRISPR/Cas9 and human-induced pluripotent stem cells. Circulation 2018;138(23):2666-2681. PMID: 29914921. PMCID: 6298866
66) Chang ACY, Chang ACH, Kirillova A, Sasagawa K, Su W, Weber G, Lin J, Termglinchan V, Karakikes I, Seeger T, Dainis AM, Hinson JT, Seidman J, Seidman CE, Day JW, Ashley E, Wu JC, Blau HM. Telomere shortening is a hallmark of genetic cardiomyopathies. Proceedings National Academy of Science 2018;115(37):9276-9281. PMID: 30150400. PMCID: 610486
67) Churko JM, Garg P, Treutlein B, Venkatasubramanian M, Wu H, Lee J, Wessells QN, Chen SY, Chen WY, Chetal K, Mantalas G, Neff N, Jabart E, Sharma A, Nolan GP, Salomonis N, Wu JC. Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis. Nature Communication 2018;9(1):4906. PMID: 30464173. PMCID: 6249224
68) Kooreman NG, Kim Y, de Almeida PE, Termglinchan V, Diecke S, Shao NY, Wei TT, Yu H, Dey D, Nelakanti R, Brouwer T, Paik DT, Barfi I, Han A, Quax PHA, Hamming JF, Levy R, Davis MM, Wu JC. iPSC-based cancer vaccination: an autologous stem cell vaccine against cancer. Cell Stem Cell 2018;22(4):501-513. PMID: 29456158. PMCID: 6134179
69) Paik DT, Tian L, Lee J, Sayed N, Chen IY, Rhee S, Rhee JW, Kim Y, Wirka RC, Buikema JW, Wu SM, Red-Horse K, Quertermous T, Wu JC. Large-scale single-cell RNA-seq reveals molecular signatures of heterogeneous populations of human induced pluripotent stem cell-derived endothelial cells. Circulation Research 2018;123:443-450. PMID: 29986945. PMCID: 6202208 (Best Manuscript Award in Circulation Research)
70) Vrtovec B, Poglajen G, Sever M, Zemljic G, Frljak S, Cerar A, Cukjati M, Jaklic M, Cernelc P, Haddad F, Wu JC. Effects of repetitive transendocardial CD34+ cell transplantation in patients with non-ischemic dilated cardiomyopathy. Circulation Research 2018;123(3):389-396. PMID: 29880546.
71) Garg P, Oikonomopoulos A, Chen H, Li Y, Lam CK, Sallam K, Perez M, Lux RL, Sanguinetti MC, Wu JC. Genome editing of induced pluripotent stem cells to decipher cardiac channelopathy variant. Journal American College Cardiology 2018;72(1):62-75. PMID: 29957233. PMCID: 6050025
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