1. Fair Complexion: Your risk of getting melanoma depends on your skin color/pigmentation, how your skin reacts to the sun (ultraviolet light) by either tanning or burning, and how much ultraviolet (UV) light exposure you have had. If you have light skin that tends to freckle and burn easily, red or blond hair, and blue or green eyes, you are especially susceptible to melanoma. People with darker complexions are at lower risk for melanoma and other skin cancers, though rates of melanoma in the US are rising in those of Asian race and Hispanic ethnicity.
2. Family History of Melanoma: Your risk of melanoma is increased if you have a family member who has the disease. While less than 10% of melanoma cases are linked to an inherited genetic trait, families tend to have similar skin coloration and reactions to the sun, as well as shared environmental UV exposures.
3. Exposure to Ultraviolet Light from the Sun: Ultraviolet-B (UV-B) radiation from the sun is the main cause of sunburn and skin cancer, although UV-A also plays a role. In people with very light skin, sunburn can occur after only a minutes of sun exposure. Having a history of five sunburns doubles your chances of getting melanoma. Sunrays that damage your skin can reflect off of water, sand and concrete and can penetrate windows.
4. Exposure to Ultraviolet Light from Tanning Beds or Sunlamps: Indoor tanning beds emit both UV-A and UV-B rays with higher concentrations than natural sunlight. If you use a tanning bed for 20 minutes, it is like spending up to 3 hours at the beach with no sun protection. Your risk of developing melanoma can increase by 20% after even one indoor tanning session. If you use a tanning bed before you are 35, your risk of melanoma increases by 75%. Indoor tanning beds are banned in Australia and Brazil, with legislation in place to ban them in other countries. In the United States, 19 states and the District of Columbia ban tanning bed access to minors (under age 18) with state bills pending for more states to do so.
5. Atypical or a Large Number of Moles: The most important clinical risk factor for melanoma is having a lot of moles, especially if these moles are larger (bigger than a pencil eraser) or look atypical. While most melanomas do not come from an existing mole, having lots of moles increases your risk of getting melanoma. A mole count of 50 or more is considered increased. People with an atypical mole pattern benefit from total body photography and routine skin monitoring by a dermatologist.
6. Age: If you are between the ages of 25 and 29, melanoma is the most common form of cancer you might suffer. Melanoma is second only to breast cancer in women between the ages of 30 and 35. Your risk of melanoma increases with age, and it is most often diagnosed if you are middle aged. About 70 percent of melanoma cases are diagnosed in people age 55 or older. While new medications (immunotherapy and molecularly targeted therapy) have reduced death rates from advanced melanoma over the past 5 years, white males over the age of 50 have a higher risk of dying from melanoma, often related to later detection of more aggressive skin tumors.
7. Employment Out-of-Doors: If you are employed out of doors, like a construction or agricultural worker, you are at more risk of developing melanoma since you will receive increased exposure to ultraviolet radiation. Some melanomas occur in chronically sun-damaged skin (face, ears, scalp, arms), while others occur in more intermittently sun-damaged skin (trunk).
8. Recreation Out-of-Doors: If you recreate out of doors, like a surfer, hiker, swimmer or other athlete, you are at greater risk of melanoma due to your increased exposure to ultraviolet radiation. Sweating may also contribute to your risk of skin damage since it makes sunscreen less effective and may increase your sensitivity to the sun.
9. Immune System-Suppressing Diseases or Treatments: If you’re immune system is suppressed due to medications you take after an organ transplant or have HIV/AIDs, you are more susceptible to melanoma and other skin cancers.
10. Previous Skin Cancers: If you have had basal or squamous cell skin cancer or precancers called actinic keratosis, you are at higher risk of developing melanoma, since these lesions are all related to UV exposure. You are also at higher risk of developing another melanoma if you have already had a skin melanoma, especially in the first 3 years after your diagnosis.