Past Symposiums

Proteomic & Genomic Deep Phenotyping in Pulmonary Arterial Hypertension

May 13, 2016, A one-day workshop immediately preceding the American Thoracic Society Annual Meeting in San Francisco

Schedule

Session 1: Proteomic Phenotyping in PH

Chairs: Marc Humbert, MD, PhD and Norbert Voelkel, MD

8:00am-8:30am

Welcome and Introductions

8:30am-9:25am

Guest Lecture

Special Guest

9:30am-10:00am

Can we apply proteomic technology for phenotyping PH? Can we use 'omic signature to identify treatment responsiveness?

Evangelos Michelakis, MD, FACC, FAHA
University of Alberta, Canada

10:05am-10:35am

Can PAH be reclassified into proteomic phenotypes? Can proteomic phenotypes be used as prognostic indicators?

Andrew Sweatt, MD
Stanford University

10:45am-11:00am: BREAK

11:00am-11:30am

How should we standardize proteomic approach for phenotyping?

Aaron Waxmann, MD, PhD
Brigham and Womans Hopsital, Boston

11:35am-12:30pm

PANEL DISCUSSION: Addressing dilemmas in the application of proteomic technology to pulmonary vascular diseases

Edda Spiekerkoetter, MD Moderator
Stanford University

Mark Nicolls, MD
Stanford University

Allan Lawrie, BSc, PhD
The University of Sheffield, England

Steven Kawut, MD, MS
University of Pennsylvania

Todd Bull, MD
University of Colorado

12:30:pm-1:30pm LUNCH

Session 2: Genomic Phenotyping in PH

Chairs: Euan Ashley, MD, MRCP, DPhil and Alexander A. Morgan, PhD

1:30:pm-2:00pm

What can genotyping PH tell us about disease?
Lessons about vasoreactivity: should we endophenotype all patients?

Anna Hemnes, MD
Vanderbilt University

2:05pm-2:35pm

Applying genomics in other respiratory diseases…what is the best case scenario?

Angela Rogers, MD
Stanford University

2:40pm-3:10pm

How do we apply large scale genotyping to a rare disease? Targeted or broad sequencing?

Tero-Pekka Alastalo, MD, PhD
Blueprint Genetics

3:15pm-3:30pm: BREAK

3:30pm-4:30pm

PANEL DISCUSSION: Identifying the role of Genomics in determining phenotype and treatment responsivity in PAH

Vinicio de Jesus Perez, MD Moderator
Stanford University

Marlene Rabinovitch, MD
Stanford University

Stephen Archer, MD
Queens University, Kingston, Ontario, Canada

Tim Lahm, MD
Indiana University

4:30-5:15pm

Q&A Debrief

Vinicio de Jesus Perez, MD Moderator
Stanford University

Edda Spiekerkoetter, MD
Stanford University

Roham Zamanian, MD
Stanford University

5:30-6:30pm

Reception

Speakers

Tero-Pekka Alastalo, MD, PhD

Pediatric Cardiologist and Principal Investigator
Helsinki University Hospital, Finland
CMO GM Blueprint Genetics

Stephen Archer, MD

Head, Department of Medicine
Queen's University
Kingston, Ontario, Canada

Euan Ashley, MD, MRCP, DPhil

Associate Professor of Medicine
Cardiovascular Medicine and Genetics
and (by courtesy) of Pathology
Stanford University

Todd Bull, MD

Director of the Pulmonary Vascular Disease Center
& Interim Director of The Center for Lungs and Breathing
University of Colorado

Vinicio de Jesus Perez, MD

Assistant Professor of Medicine
Pulmonary and Critical Care Medicine
Stanford University

Anna Hemnes, MD

Assistant Professor of Medicine
Assistant Director of Pulmonary and Critical Care Medicine
Vanderbilt University

Marc Humbert, MD, PhD

Professor of Respiratory Medicine
Vice Chair National Reference Centre for Pulmonary Hypertension
Université Paris-Sud

Steven Kawut, MD, MS

Professor of Medicine
Director, Pulmonary Vascular Disease Program
University of Pennsylvania

Tim Lahm, MD

Associate Professor of Medicine and Cellular & Integrative Physiology
Catherine and Lowe Berger and Pauline L. Ford Investigator of Pulmonary Medicine
Director of Pulmonary Research
Co-director, Pulmonary Hypertension Program
Indiana University

Allan Lawrie, BSc, PhD

BHF Senior Basic Science Research Fellow
Head of Pulmonary Vascular Research Group
Department of Cardiovascular Science
The University of Sheffield
Sheffield, England

Evangelos Michelakis, MD, FACC, FAHA

Professor of Medicine
Vice Chair, Research, Department of Medicine
Director, Pulmonary Hypertension Program
Canada Research Chair in Applied Molecular and Mitochondrial Medicine
University of Alberta, Canada

Alexander A. Morgan, PhD

MD Student, Stanford University
Scientist in Residence, Khosla Ventures

Mark Nicolls, MD

Professor of Medicine
Chief, Pulmonary and Critical Care Medicine
Stanford University

Marlene Rabinovitch, MD

Dwight and Vera Dunlevie Professor in Pediatric Cardiology
and (by courtesy) Developmental Biology
Stanford University

Angela Rogers, MD

Assistant Professor of Medicine
Pulmonary and Critical Care Medicine
Stanford University

Edda Spiekerkoetter, MD

Assistant Professor of Medicine
Pulmonary and Critical Care Medicine
Stanford University

Andrew Sweatt, MD

Postdoctoral Medical Fellow
Pulmonary and Critical Care Medicine
Stanford University

Norbert Voelkel, MD

Professor (Affiliate)
School of Pharmacy
Virginia Commonwealth University

Aaron Waxman, MD, PhD

Director, Pulmonary Hypertension Program
Executive Director, Center for Pulmonary Heart Diseases
Brigham and Womans Hopsital, Boston

Roham Zamanian, MD

Associate Professor of Medicine
Pulmonary and Critical Care Medicine
Director, Adult Pulmonary Hypertension Program
Stanford University

Guest Faculty

Tero-Pekka Alastalo, MD, PhD
Helsinki Univeristy Hospital

Stephen Archer, MD
Queen’s University - Kingston, Canada

Todd Bull, MD
University of Colorado

Anna Hemnes, MD
Vanderbilt University

Marc Humbert, MD, PhD
Université Paris-Sud

Steven Kawut, MD, MS
University of Pennsylvania

Tim Lahm, MD
Indiana Univeristy

Allan Lawrie, PhD
University of Sheffield Medical School

Evangelos Michelakis, MD
University of Alberta

Norbert Voelkel, MD
Virginia Commonwealth University

Aaron Waxman, MD
Brigham and Womans Hopsital, Boston

Stanford Faculty

Euan Ashley, MD
Cardiovascular, Genetics, Pathology

Vinicio de Jesus Perez, MD (Symposium Committee)
Pulmonary and Critical Care Medicine

Alexander A. Morgan, PhD
MD Student, Stanford University
Scientist in Residence, Khosla Ventures

Mark Nicolls, MD
Pulmonary and Critical Care Medicine

Marlene Rabinovitch, MD
Pediatric Cardiology

Angela Rogers, MD
Pulmonary and Critical Care Medicine

Edda Spiekerkoetter, MD (Symposium Committee)
Pulmonary and Critical Care Medicine

Andrew Sweatt, MD
Pulmonary and Critical Care

Roham Zamanian, MD (Symposium Chair)
Pulmonary and Critical Care Medicine

Videos

Introduction

Roham Zamanian, MD
Stanford University

Can PAH be reclassified into proteomic phenotypes? Can proteomic phenotypes be used as prognostic indicators?

Andrew Sweatt, MD,
Stanford University

What can genotyping PH tell us about disease? Lessons about vasoreactivity: should we endophenotype all patients?

Anna Hemnes, MD
Vanderbilt University

PANEL DISCUSSION: Addressing dilemmas in the application of proteomic technology to pulmonary vascular diseases

Edda Spiekerkoetter, MD Moderator, Mark Nicolls, MD Stanford University, Allan Lawrie, BSc, PhD, The University of Sheffield, England, Steven Kawut, MD, MS, University of Pennsylvania, Todd Bull, MD, University of Colorado

From Butterflies to Blackbirds

Brain Shul
Retired United States Air Force Fighter Pilot
Special Guest Speaker

How should we standardize proteomic approach for phenotyping?

Aaron Waxmann, MD, PhD
Brigham and Womans Hopsital, Boston

Applying genomics in other respiratory diseases…what is the best case scenario?

Angela Rogers, MD
Stanford University

Can we apply proteomic technology for phenotyping PH? Can we use 'omic signature to identify treatment responsiveness?

Evangelos Michelakis, MD, FACC, FAHA
University of Alberta

PANEL DISCUSSION: Addressing dilemmas in the application of proteomic technology to pulmonary vascular diseases

How do we apply large scale genotyping to a rare disease? Targeted or broad sequencing?

Tero-Pekka Alastalo, MD, PhD
Blueprint Genetics

Immunity and the Pathogenesis of Pulmonary Arterial Hypertension

November 6, 2015, A one-day workshop immediately preceding the American College of Rheumatology Annual Meeting in San Francisco

Schedule

Download the schedule

Morning Sessions

8:00am-8:15am

Check in/Breakfast/Coffee

8:15am

Welcome

Mark Krasnow, MD, PhD
Stanford University

8:30am-8:50am

Introduction to pulmonary arterial hypertension (PAH): a clinical perspective

Kristina Kudelko, MD
Stanford University

8:50am-9:10am

Introduction to immunity and immune dysfunction: what are the key players?

Mark Nicolls, MD
Stanford University

9:10am-9:40am: KEYNOTE TALK

A brief history of immunity and PAH

Marc Humbert, MD, PhD
Université Paris-Sud

9:40am-10:00am

Pulmonary hypertension, inflammation, and immune response: the long way from thought to action

Norbert Voelkel, MD
Virginia Commonwealth University

10:00am-10:20am: BREAK

10:20am-10:40am

Interface of TH2 inflammation and TGF-beta signaling in pulmonary hypertension

Rubin Tuder, MD
University of Colorado Denver

10:40am-11:00am

CtBP1, a transcriptional co-repressor, links changes in cell metabolism to inflammation in chronic pulmonary hypertension

Kurt Stenmark, MD
University of Colorado Denver

11:00am-11:20am

Examination of cardiopulmonary function in mouse models of natural killer cell deficiency

Mark Ormiston, PhD
University of Cambridge

11:20am-11:40am

Sequencing antibody repertoires to decipher pathogenic mechanisms in PAH

William Robinson, MD
Stanford University

11:40 am-12:10pm: ROUND TABLE DISCUSSION

Is there a causative link between immunity and PAH?
A clinical perspective

Ross Metzger, PhD Moderator
Stanford University

Steve Abman, MD
University of Colorado Denver

Mark Nicolls, MD
Stanford University

Edda Spiekerkoetter, MD
Stanford University

Virginia Steen, MD
Georgetown University

PJ Utz, MD
Stanford University

Afternoon Sessions

12:10pm-1:10pm LUNCH

1:10pm-1:40pm: KEYNOTE TALK

Immunology taught by humans

Mark Davis, PhD
Stanford University

1:40pm-2:00pm

Novel insights into lung autoimmunity through research in rare Mendelian diseases

Anthony Shum, MD
University of California San Francisco

2:00pm-2:20pm

Regulation of pulmonary macrophage function in health and disease

Bruce Trapnell, MD
University of Cincinnati

2:20pm-2:40pm

A proteomic approach to altered innate and adaptive immunity in the pathogenesis of PAH

Marlene Rabinovitch, MD
Stanford University

2:40pm-3:00pm

Autoantibodies in Systemic Sclerosis-Associated Pulmonary Hypertension

Thomas Medsger, MD
University of Pittsburgh

3:00pm-3:20pm: BREAK

3:20pm-3:40pm

Role of T-Regulatory cells in immune modulation

Maria Grazia Roncarolo, MD
Stanford University

3:40pm-4:00pm

Immunosuppression in the treatment of CTD-PAH

Lorinda Chung, MD
Stanford University

4:00pm-4:30pm: CLINICAL ROUND TABLE

Immunity and PAH: implication for clinical practice

Yon Sung, MD Moderator
Stanford University

Lorinda Chung, MD
Stanford University

Paul Hassoun, MD
Johns Hopkins Medicine

Marc Humbert, MD, PhD
Université Paris-Sud

Roham Zamanian, MD
Stanford University

4:30-5:15pm: Reception

Speakers

Download the list of speakers

Steve Abman, MD

Professor of Pediatrics
Pediatric Pulmonary Medicine
Director, Pediatric Heart-Lung Center
University of Colorado Denver

Lorinda Chung, MD

Associate Professor of Medicine
Immunology, Rheumatology and Dermatology
Stanford University

Mark Davis, PhD

Professor of Microbiology and Immunology
Director, Stanford Institute for Immunity, Transplantation and Infection
Stanford University

Paul Hassoun, MD

Professor of Medicine
Pulmonary and Critical Care Medicine
Director, Pulmonary Hypertension Program
Johns Hopkins Medicine

Marc Humbert, MD, PhD

Professor of Respiratory Medicine
Vice Chair National Reference Centre for Pulmonary Hypertension
Université Paris-Sud

Mark Krasnow, MD, PhD

Professor of Biochemistry
Executive Director, Vera Moulton Wall Center
Stanford University

Kristina Kudelko, MD

Clinical Assistant Professor of Medicine
Pulmonary and Critical Care Medicine
Stanford University

Thomas Medsger, MD

Gerald P. Rodnan Professor of Medicine in the Division of Rheumatology
University of Pittsburgh

Ross Metzger, PhD

Instructor
Cardiovascular Institute
Stanford University

Mark Nicolls, MD

Associate Professor of Medicine
Chief, Pulmonary and Critical Care Medicine
Stanford University

Mark Ormiston, PhD

Assistant Professor
Biomedical and Molecular Sciences
Queen’s University - Kingston, Canada

Marlene Rabinovitch, MD

Dwight and Vera Dunlevie Professor in Pediatric Cardiology
Stanford University

William Robinson, MD

Associate Professor of Medicine
Immunology and Rheumatology
Stanford University

Maria Grazia Roncarolo, MD

George D. Smith Professor in Stem Cell
Transplantation and Regenerative Medicine Professor of Pediatrics and of Medicine (blood and marrow transplantation)
Co-Director, Institute for Stem Cell Biology and Regenerative Medicine
Stanford University

Anthony Shum, MD

Assistant Professor of Medicine
Pulmonary and Critical Care
University of California, San Francisco

Edda Spiekerkoetter, MD

Assistant Professor of Medicine
Pulmonary and Critical Care Medicine
Stanford University

Virginia Steen, MD

Professor of Medicine Rheumatology
Director, Rheumatology Fellowship Program
Georgetown University

Kurt Stenmark, MD

Professor of Pediatrics, Medicine and Anesthesiology
Head, Division of Pediatric and Critical Care Medicine
Director, Cardiovascular Pulmonary Research and Developmental Lung Biology Labs
University of Colorado Denver

Yon Sung, MD

Clinical Instructor of Medicine
Pulmonary and Critical Care Medicine
Stanford University

Bruce Trapnell, MD

Francis R. Luther Professor of Medicine and Pediatrics
University of Cincinnati

Rubin Tuder, MD

Professor of Medicine and Pathology
Pulmonary Sciences & Critical Care Medicine
Director, Program in Translational Lung Research
University of Colorado Denver

PJ Utz, MD

Professor of Medicine Immunology and Rheumatology
Stanford University

Norbert Voelkel, MD

Professor (Affiliate)
School of Pharmacy
Virginia Commonwealth University

Roham Zamanian, MD

Associate Professor of Medicine
Pulmonary and Critical Care Medicine
Director, Adult Pulmonary Hypertension Program
Stanford University

Videos

Welcome

Mark Krasnow, MD, PhD
Stanford University

A brief history of immunity and PAH

Marc Humbert, MD, PhD
Université Paris-Sud

Examination of cardiopulmonary function in mouse models of natural killer cell deficiency

Mark Ormiston, PhD
University of Cambridge

Immunology taught by humans

Mark Davis, PhD
Stanford University

A proteomic approach to altered innate and adaptive immunity in the pathogenesis of PAH

Marlene Rabinovitch, MD
Stanford University

Immunosuppression in the treatment of CTD-PAH

Lorinda Chung, MD
Stanford University

Introduction to pulmonary arterial hypertension (PAH): a clinical perspective

Kristina Kudelko, MD
Stanford University

Pulmonary hypertension, inflammation, and immune response: the long way from thought to action

Norbert Voelkel, MD
Virginia Commonwealth University

Sequencing antibody repertoires to decipher pathogenic mechanisms in PAH

William Robinson, MD
Stanford University

Novel insights into lung autoimmunity through research in rare Mendelian diseases

Anthony Shum, MD
University of California San Francisco

Autoantibodies in Systemic Sclerosis-Associated Pulmonary Hypertension

Thomas Medsger, MD
University of Pittsburgh

Immunity and PAH: implication for clinical practice

Yon Sung, MD Moderator, Lorinda Chung, MD, Roham Zamanian, MD, Stanford University
Paul Hassoun, MD, Johns Hopkins Medicine
Marc Humbert, MD, PhD, Université Paris-Sud

Introduction to immunity and immune dysfunction: what are the key players?

Mark Nicolls, MD
Stanford University

Interface of TH2 inflammation and TGF-beta signaling in pulmonary hypertension

Rubin Tuder, MD
University of Colorado Denver

Is there a causative link between immunity and PAH? A clinical perspective

Ross Metzger, PhD Moderator, Mark Nicolls, MD, Edda Spiekerkoetter, MD, PJ Utz, MD, Stanford University
Steve Abman, MD, University of Colorado Denver, Virginia Steen, MD, Georgetown University

Regulation of pulmonary macrophage function in health and disease

Bruce Trapnell, MD
University of Cincinnati

Role of T-Regulatory cells in immune modulation

Maria Grazia Roncarolo, MD
Stanford University

BMPR2 in Pulmonary Hypertension: Charting the Future

September 10, 2012, Celebrating the First Decade

Schedule

Morning Sessions

11:00-11:20

The disease: pulmonary hypertension--an introduction

Roham Zamanian, MD
Stanford University

11:20-11:40

The pathway: BMP signaling--an introduction

Edda Spiekerkoetter, MD
Stanford University

Afternoon Sessions

12:00-12:10

Introduction and vision

Mark Krasnow, MD, PhD
Stanford University

12:10-1:00

BMPR2 mutations in PH: From discovery to present time

James Loyd, MD
Vanderbilt University

1:00-1:50

The BMPR2 pathway: From a basic scientist’s perspective

Jeff Wrana, PhD
University of Toronto, Canada

1:50-2:00 Break

2:00-2:10

There must be more BMP pathway genes than BMPR2 involved in PH: What are they and why haven’t they been identified by human genetics?

Dean Li, MD, PhD
University of Utah

2:10-2:30 Panel Discussion

Micheala Aldred, PhD
Cleveland Clinic

Dean Li, MD, PhD
University of Utah

James West, PhD
Vanderbilt University

2:30-2:40

What are the most important cellular players in PH?

Marlene Rabinovitch, MD
Stanford University

2:40-3:00 Panel Discussion

Nicholas Morrell, MD
University of Cambridge, England

Marlene Rabinovitch, MD
Stanford University

Kurt Stenmark, MD
University of Colorado Denver

Norbert Voelkel, MD
Virginia Commonwealth University

3:00-3:10

Is BMPR2 important in non-familial forms of PH?

Vinicio de Jesus Perez, MD
Stanford University

3:10-3:30 Panel Discussion

Stephen Archer, MD
Queen's Univeristy
Kingston, Ontario, Canada

Euan Ashley, MD, PhD
Stanford University

David Cornfield, MD
Stanford University

Vinicio de Jesus Perez, MD
Stanford University

Marc Humbert, MD, PhD
Stanford University

3:30-3:40 Break

3:40-3:50

Can we detect and trace dysfunctional BMPR2 signaling in vivo?

Pehr Harbury, PhD
Stanford University

3:50-4:10 Panel Discussion

Christopher Contag, PhD
Stanford University

Vinicio de Jesus Perez, MD
Stanford University

Pehr Harbury, PhD
Stanford University

4:10-4:20

Can we modulate the BMPR2 pathway in vivo?

Edda Spiekerkoetter, MD
Stanford University

4:20-4:40 Panel Discussion

Edda Spiekerkoetter, MD
Stanford University

Mark Nicolls, MD
Stanford University

4:40-5:00

Lessons for the clinician: How can we apply our knowledge about BMP signaling clinically?

Colleen Caleshu, ScM, CGC
Stanford University

Jeffrey Feinstein, MD, MPH
Stanford University

Roham Zamanian, MD
Stanford University

5:00-5:30 Reception

Speakers

Guest Faculty

Micheala Aldred, PhD
Cleveland Clinic

Stephen Archer, MD
Queen's University, Kingston, Ontario, Canada

Marc Humbert, MD, PhD
South Paris University-Clamart, France

Dean Li, MD, PhD
University of Utah

James Loyd, MD
Vanderbilt University

Nicholas Morrell, MD
University of Cambridge

Kurt Stenmark, MD
University of Colorado Denver

Norbert Voelkel, MD
Virginia Commonwealth University

James West, PhD
Vanderbilt University

Jeff Wrana, PhD
Mount Sinai Hospital
University of Toronto

Stanford Faculty

Euan Ashley, MD, PhD
Cardiovascular Medicine

Colleen Caleshu, ScM, CGC
Center for Inherited Cardiovascular Disease

Christopher Contag, PhD
Neonatology, Microbiology and Immunology

David Cornfield, MD
Pediatric Pulmonary Medicine

Jeffrey Feinstein, MD, MPH
Pediatric Cardiology

Pehr Harbury, PhD
Biochemistry

Vinicio de Jesus Perez, MD
Pulmonary and Critical Care Medicine

Mark Krasnow, MD, PhD
Biochemistry

Mark Nicolls, MD
Pulmonary and Critical Care Medicine

Marlene Rabinovitch, MD
Pediatric Cardiology

Edda Spiekerkoetter, MD
Pulmonary and Critical Care Medicine

Roham Zamanian, MD
Pulmonary and Critical Care Medicine

Photos

Mark Krasnow, MD, PhD

Executive Director, Vera Moulton Wall Center and Professor of Biochemistry speaks at the 10th Anniversary Symposium

More photos