Publications

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2023

Ayoglu, B., Donato, M., Furst, D.E., Crofford, L.J., Goldmuntz, E., Keyes-Elstein, L., James, J., Macwana, S., Mayes, M.D., McSweeney, P., Nash, R.A., Sullivan, K.M., Welch, B., Pinckney, A., Mao, R., Chung, L., Khatri, P., Utz, P.J. Characterising the autoantibody repertoire in systemic sclerosis following myeloablative haematopoietic stem cell transplantation. Ann Rheum Dis. 2023 Jan 18:annrheumdis-2021-221926. doi: 10.1136/ard-2021-221926. Epub ahead of print. PMID: 36653124. Download PDF file.

de Carvalho, R.V.H., Ersching, J., Barbulescu, A., Hobbs, A., Castro, T.B.R., Mesin, L., Jacobsen, J.T., Phillips, B.K., Hoffmann, H.H., Parsa, R., Canesso, M.C.C., Nowosad, C.R., Feng, A., Leist, S.R., Baric, R.S., Yang, E., Utz, P.J., Victora, G.D. Clonal replacement sustains long-lived germinal centers primed by respiratory viruses. Cell. 2023 Jan 5;186(1):131-146.e13. doi: 10.1016/j.cell.2022.11.031. Epub 2022 Dec 23. PMID: 36565697; PMCID: PMC9870066. Download PDF file.

Feng, A., Yang, E.Y., Moore, A.R., Dhingra, S., Chang,S.E., Yin, X., Pi, R., Mack, E.K., Völkel, S., Geßner, R., Gündisch, M., Neubauer, A., Renz, H., Tsiodras, S., Fragkou, P.C., Asuni, A.A., Levitt, J.E., Wilson, J.G., Leong, M., Lumb, J.H., Mao, R., Pinedo, K., Roque, J., Richards, C.M., Stabile, M., Swaminathan, G., Salagianni, M.L., Triantafyllia, V., Bertrams, W., Blish, C.A., Carette, J.E., Frankovich, J., Meffre, E., Nadeau, K.C., Singh, U., Wang, T.T., Luning Prak, E.T., Herold, S., Andreakos, E., Schmeck, B., Skevaki, C,, Rogers, A.J., Utz, P.J. Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness. JCI Insight. 2023 Feb 8;8(3):e163150. doi: 10.1172/jci.insight.163150. PMID: 36752204. Downlaod PDF file.

Ganesan, A., Dermadi, D., Kalesinskas, L., Donato, M., Sowers, R., Utz, P.J., Khatri, P. Inferring direction of associations between histone modifications using a neural processes-based framework. iScience. 2022 Dec 7;26(1):105756. doi: 10.1016/j.isci.2022.105756. PMID: 36619977; PMCID: PMC9813700. Download PDF file.

Ty M, Sun S, Callaway PC, Rek J, Press KD, van der Ploeg K, Nideffer J, Hu Z, Klemm S, Greenleaf W, Donato M, Tukwasibwe S, Arinaitwe E, Nankya F, Musinguzi K, Andrew D, de la Parte L, Mori DM, Lewis SN, Takahashi S, Rodriguez-Barraquer I, Greenhouse B, Blish C, Utz PJ, Khatri P, Dorsey G, Kamya M, Boyle M, Feeney M, Ssewanyana I, Jagannathan P. Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria. Sci Transl Med. 2023 Jan 25;15(680):eadd9012. doi: 10.1126/scitranslmed.add9012. Epub 2023 Jan 25. PMID: 36696483. Download PDF.

Zaslavsky, M.E., Craig, E., Michuda, J.K., Ram-Mohan, N., Lee, J.Y., Nguyen, K.D., Hoh, R.A., Pham, T.D., Parsons, E.S., Macwana, S.R., DeJager, W., Roskin, K.M., Cunningham-Rundles, C., Moody, M.A., Haynes, B.F., Goldman, J.D., Heath, J.R., Balboni, I., Utz, P.J., Nadeau, K.C., Pinsky, B.A., Blish, C.A., Merrill, J.T., Guthridge, J.M., James, J.A., Yang, S., Tibshirani, R., Kundaje, A., Boyd, S.D. Disease diagnostics using machine learning of immune receptors. bioRxiv [Preprint]. 2023 Jan 31:2022.04.26.489314. doi: 10.1101/2022.04.26.489314. PMID: 35547855; PMCID: PMC9094102. Download PDF file.

2022

Aguilera, J, Han, X., Cao, S., Balmes, J., Lurmann, F., Tyner, T., Lutzker, L., Noth, E., Hammond, SK, Sampath V, Burt T, Utz PJ, Khatri P, Aghaeepour N, Maecker H, Prunicki M, Nadeau K. Increases in ambient air pollutants during pregnancy are linked to increases in methylation of IL4, IL10, and IFNγ. Clin Epigenetics. 2022 Mar 14;14(1):40. doi: 10.1186/s13148-022-01254-2. PMID: 35287715; PMCID: PMC8919561. Download PDF file.

Bai, L., Dermadi, D., Kalesinskas, L., Dvorak, M., Chang, S.E., Ganesan, A., Rubin, S.J.S., Kuo, A., Cheung, P., Donato, M., Utz, P.J., Habtezion, A., Khatri, P. Mass-cytometry-based quantitation of global histone post-translational modifications at single-cell resolution across peripheral immune cells in IBD. J Crohns Colitis. 2022 Dec 26:jjac194. doi: 10.1093/ecco-jcc/jjac194. Epub ahead of print. PMID: 36571819. Download PDF files.

Carlucci, P.M., Li, J., Fava, A., Deonaraine, K.K., Wofsy, D., James, J.A., Putterman, C., Diamond, B., Davidson, A., Fine, D.M., Monroy-Trujillo, J., Atta, M.G., DeJager, W., Guthridge, J.M., Haag, K., Rao, D.A., Brenner M,B., Lederer, J.A., Apruzzese, W., Belmont, H.M., Izmirly, P.M., Zaminski, D., Wu, M., Connery, S., Payan-Schober, F., Furie, R., Dall'Era, M., Cho, K., Kamen, D., Kalunian,K., Anolik, J., Barnas, J., Ishimori, M., Weisman, M.H.; Accelerating Medicines Partnership (AMP) RA/SLE Network; Buyon, J.P., Petri, M. High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership. Rheumatology (Oxford). 2022 Nov 2;61(11):4335-4343. doi: 10.1093/rheumatology/keac067. PMID: 35212719; PMCID: PMC9629353. Download PDF file.

Chakraborty ,S., Gonzalez, J.C., Sievers, B.L., Mallajosyula, V., Chakraborty, S., Dubey, M., Ashraf, U., Cheng, B.Y., Kathale, N., Tran, K.Q.T., Scallan, C., Sinnott, A., Cassidy, A., Chen, S.T., Gelbart, T., Gao, F., Golan, Y., Ji, X., Kim-Schulze, S., Prahl, M., Gaw, S.L., Gnjatic. S., Marron, T.U., Merad, M., Arunachalam, P.S., Boyd, S.D., Davis, M.M., Holubar. M., Khosla, C., Maecker, H.T., Maldonado, Y., Mellins, E.D., Nadeau, K.C., Pulendran, B., Singh, U., Subramanian, A., Utz. P.J., Sherwood, R., Zhang, S., Jagannathan, P., Tan, G.S., Wang. T.T., 2022.  Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity. Sci Transl Med. 2022 Jan 18:eabm7853. doi: 10.1126/scitranslmed.abm7853. Download PDF File.

Kolstad, K.D., Khatri, A., Donato, M., Chang, S.E., Li, S., Steen, V.D., Utz, P.J., Khatri, P., Chung, L., 2022. Cytokine signatures differentiate systemic sclerosis patients at high versus low risk for pulmonary arterial hypertension. Arthritis Res Ther. 2022 Feb 9;24(1):39. doi: 10.1186/s13075-022-02734-9.PMID: 35139913. Download PDF file.

Li J, Zaslavsky M, Su Y, Guo J, Sikora MJ, van Unen V, Christophersen A, Chiou SH, Chen L, Li J, Ji X, Wilhelmy J, McSween AM, Palanski BA, Mallajosyula VVA, Bracey NA, Dhondalay GKR, Bhamidipati K, Pai J, Kipp LB, Dunn JE, Hauser SL, Oksenberg JR, Satpathy AT, Robinson WH, Dekker CL, Steinmetz LM, Khosla C, Utz PJ, Sollid LM, Chien YH, Heath JR, Fernandez-Becker NQ, Nadeau KC, Saligrama N, Davis MM. KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19. Science. 2022 Apr 15;376(6590):eabi9591. doi: 10.1126/science.abi9591. Epub 2022 Apr 15. PMID: 35258337; PMCID: PMC8995031. Download PDF file. 

Ravi, N., Chang, S.E., Franco, L.M., Nagaman,i S.C.S., Khatri, P., Utz, P.J., Wang, S.X., 2022. A GMR-based assay for quantification of the human response to influenza. Biosens Bioelectron. 2022 Feb 17;205:114086. doi: 10.1016/j.bios.2022.114086. Download PDF file.

Utz, P.J., Jain M.K., Cheung, V.G., Kobilka, B.K., Lefkowitz, R., Yamada, T., Dzau V.J., 2022. Translating science to medicine: The case for physician-scientists. Sci Transl Med. 2022 Feb 16;14(632):eabg7852. doi: 10.1126/scitranslmed.abg7852. Epub 2022 Feb 16. PMID: 35171650. Download PDF file.

Yiu, G., Rasmussen, T.K., Tsai, B.L., Diep, V.K., Haddon, D.J., Tsoi, J., Miller, G.D., Comin-Anduix, B., Deleuran, B., Crooks, G.M., Utz, P.J., 2022. High Interferon Signature Leads to Increased STAT1/3/5 Phosphorylation in PBMCs From SLE Patients by Single Cell Mass Cytometry. Front Immunol. 2022 Jan 28;13:833636. doi: 10.3389/fimmu.2022.833636. eCollection 2022.PMID: 35185925. Download PDF file.

2021

Arunachalam, P.S., Scott, M.K.D., Hagan, T., Li, C., Feng, Y., Wimmers, F., Grigoryan, L., Trisal, M., Edara, V.V., Lai, L., Chang, S.E., Feng, A., Dhingra, S., Shah, M., Lee, A.S., Chinthrajah, S., Sindher, S.B., Mallajosyula, V., Gao, F., Sigal, N., Kowli, S., Gupta, S., Pellegrini, K., Tharp, G., Maysel-Auslender, S., Hamilton, S., Aoued, H., Hrusovsky, K., Roskey, M., Bosinger, S.E., Maecker, H.T., Boyd, S.D., Davis, M.M., Utz, P.J., Suthar, M.S., Khatri, P., Nadeau, K.C., Pulendran, B. 2021. Systems vaccinology of the BNT162b2 mRNA vaccine in humans. Nature. 2021 Aug;596(7872):410-416. doi: 10.1038/s41586-021-03791-x. Epub 2021 Jul 12.PMID: 34252919. Download PDF file.

Chakraborty S, Gonzalez JC, Sievers BL, Mallajosyula V, Chakraborty S, Dubey M, Ashraf U, Cheng BY, Kathale N, Tran KQT, Scallan C, Sinnott A, Cassidy A, Chen ST, Gelbart T, Gao F, Golan Y, Ji X, Kim-Schulze S, Prahl M, Gaw SL, Gnjatic S, Marron TU, Merad M, Arunachalam PS, Boyd SD, Davis MM, Holubar M, Khosla C, Maecker HT, Maldonado Y, Mellins ED, Nadeau KC, Pulendran B, Singh U, Subramanian A, Utz PJ, Sherwood R, Zhang S, Jagannathan P, Tan GS, Wang TT., 2021. Structurally and functionally distinct early antibody responses predict COVID-19 disease trajectory and mRNA vaccine response. bioRxiv 2021 Dec 27;2021.05.25.445649. doi: 10.1101/2021.05.25.445649. Download PDF file.

Chang ,S.E., Feng, A., Meng, W., Apostolidis, S.A., Mack, E., Artandi, M., Barman, L., Bennett, K., Chakraborty, S., Chang, I., Cheung, P., Chinthrajah, S., Dhingra, S., Do, E., Finck, A., Gaano, A., Geßner, R., Giannini, H.M., Gonzalez, J., Greib, S., Gündisch, M., Hsu, A.R., Kuo, A., Manohar, M., Mao, R., Neeli, I., Neubauer, A., Oniyide, O., Powell, A.E., Puri, R., Renz, H., Schapiro, J., Weidenbacher, P.A., Wittman, R., Ahuja, N., Chung, H.R., Jagannathan, P., James, J.A., Kim, P.S., Meyer, N.J., Nadeau, K.C., Radic, M., Robinson, W.H., Singh, U., Wang, T.T., Wherry, E.J., Skevaki, C., Luning Prak, E.T., Utz, P.J., 2021. New-onset IgG autoantibodies in hospitalized patients with COVID-19. Nat Commun. 2021 Sep 14;12(1):5417. doi: 10.1038/s41467-021-25509-3. Download PDF file.

Cheung, P., Schaffert, S., Chang, S.E., Dvorak, M., Donato, M., Macaubas, C., Foecke, M.H., Li, T.M., Zhang, L., Coan, J.P., Schulert, G.S., Grom, A.A., Henderson, L.A., Nigrovic, P.A., Elias, J.E., Gozani, O., Mellins, E.D., Khatri, P., Utz, P.J., Kuo, A.J., 2021. Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation. Nat Immunol. 2021 Jun;22(6):711-722. doi: 10.1038/s41590-021-00928-y. Epub 2021 May 20. Download PDF file.

Knight, J.S., Caricchio, R., Casanova ,J.L., Combes, A.J., Diamond, B., Fox, S.E., Hanauer, D.A., James, J.A., Kanthi, Y., Ladd, V., Mehta, P., Ring, A.M., Sanz, I., Selmi, C., Tracy, R.P., Utz, P.J., Wagner, C.A., Wang, J.Y., McCune, W.J., 2021. The intersection of COVID-19 and autoimmunity. J Clin Invest. 2021 Dec 15;131(24):e154886. doi: 10.1172/JCI154886. Download PDF file.

Li, J., Zaslavsky, M., Su, Y., Sikora, M.J., van Unen, V., Christophersen, A., Chiou, S.H., Chen, L., Li, J., Ji, X., Wilhelmy, J., McSween, A.M., Palanski, B.A., Aditya Mallajosyula, V.V., Dhondalay, G.K.R., Bhamidipati, K., Pai, J., Kipp, L.B., Dunn, J.E., Hauser, S.L., Oksenberg, J.R., Satpathy, A.T., Robinson, W.H., Steinmetz, L.M., Khosla, C., Utz, P.J., Sollid, L.M., Heath, J.R., Fernandez-Becker, N.Q., Nadeau, K.C., Saligrama, N., Davis, M.M. Human KIR + CD8 + T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19. bioRxiv. 2021 Dec 25:2021.12.23.473930. doi: 10.1101/2021.12.23.473930. Preprint.PMID: 34981055. Download PDF file.

McElvaine, A.T., Hawkins-Salsbury, J.A., Arora, V.M., Gladwin, M.T., Goldenring, J.R., Huston, D.P., Krakow, D., Rhee, K., Solway, J., Steinman, R.A., Towler, D.A., Utz, P.J., Yokoyama, W.M., Simpson, R.L., Muglia, L.J., Permar, S.R., Gbadegesin, R.A. , 2021. Innovations in MD-only physician-scientist training: experiences from the Burroughs Wellcome Fund physician-scientist institutional award initiative. J Clin Invest. 2021 May 17;131(10):e149948. doi: 10.1172/JCI149948. Download PDF file.

Utz, P.J., Jain, M.K., Cheung, V.G., Kobilka, B.K., Lefkowitz, R., Yamada, T., Dzau, V.J. Translating science to medicine: The case for physician-scientists. Sci Transl Med. 2022 Feb 16;14(632):eabg7852. doi: 10.1126/scitranslmed.abg7852. Epub 2022 Feb 16.PMID: 35171650. Download PDF file.

Wimmers, F., Donato, M., Kuo, A., Ashuach, T., Gupta, S., Li, C., Dvorak, M., Foecke, M.H., Chang, S.E., Hagan, T., De Jong, S.E., Maecker, H.T., van der Most, R., Cheung, P., Cortese, M., Bosinger, S.E., Davis, M., Rouphael, N., Subramaniam ,S., Yosef, N., Utz., P.J., Khatri, P., Pulendra, B. The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination. Cell. 2021 Jul 22;184(15):3915-3935.e21. doi: 10.1016/j.cell.2021.05.039. Epub 2021 Jun 25. Download PDF file.

2020

Bernstein D, Irvine CA, Basaviah P, Lau JN, Austin B, Utz PJ, Gesundheit N. Stanford University School of Medicine. Acad Med. 2020 Sep;95(9S A Snapshot of Medical Student Education in the United States and Canada: Reports From 145 Schools):S50-S53. doi: 10.1097/ACM.0000000000003493. PMID: 33626643.

Haynes, W.A., Haddon, D.J., Diep, V.K., Khatri, A., Bongen, E., Yiu, G., Balboni, I., Bolen, C.R., Mao, R., Utz, P.J., Khatri, P. Integrated, multicohort analysis reveals unified signature of systemic lupus erythematosus. JCI Insight. 2020 Feb 27;5(4):e122312. doi: 10.1172/jci.insight.122312. PMID: 31971918; PMCID: PMC7101149. Download PDF file.

James, J.A., Guthridge, J.M., Chen, H., Lu, R.,  Bourn,R.L.,  Bean, K., Munroe, M.E.,  Smith,M.,  Chakravarty, W., Baer, A.N.,  Noaiseh, G.,  Parke, A., Boyle, K., Keyes-Elstein, L., Coca, A., Utset, T., Genovese, M.C., Pascual, V.,  Utz, P.J., Holers, V.M., Deane, K.D.,  Sivils, K.L.,  Aberle,T., Wallace, D.J., McNamara, J., Franchimont, N., St. Clair, E.W., 2020. Unique Sjögren’s syndrome patient subsets defined by molecular features, Rheumatology, 59(4):860868, https://doi.org/10.1093/rheumatology/kez335. Download PDF File.

Simoni, L., Presumey, J., van der Poel, C.E., Castrillon, C., Changm, S.E., Utz, P.J., Carroll, M.C., 2020. Complement C4A Regulates Autoreactive B Cells in Murine Lupus. Cell Rep. 2020 Nov 3;33(5):108330. doi: 10.1016/j.celrep.2020.108330. Download PDF file.

 Slight-Webb, S.,  Smith, M.,  Bylinska, A., Macwana, S.,Guthridge, C.,  Lu, R., MD, Merrill, J.T.,  Chakravarty, W., Arriens, C., Munroe, M.E., Maecker, H.T., Utz, P.J., Guthridge, J.M. and James, J.A., 2020. Autoantibody-positive healthy individuals with lower lupus risk display a unique immune endotype. J. Allergy Clin. Immunol. 2020 May 22;S0091-6749(20)30675-8. doi: 10.1016/j.jaci.2020.04.047. Online ahead of print. Download PDF file.

Wei, K., Korsunsky, I., Marshall, J.L., Gao, A., Watts, G.F.M., Major, T., Croft. A.P., Watts, J., Blazar, P.E., Lange, J.K., Thornhill, T.S., Filer, A., Raza, K., Donlin, L.T.; Accelerating Medicines Partnership Rheumatoid Arthritis & Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Siebel, C.W., Buckley, C.D., Raychaudhuri, S., Brenner, M.B., 2020 Notch signalling drives synovial fibroblast identity and arthritis pathology. Nature. 2020 Jun;582(7811):259-264. doi: 10.1038/s41586-020-2222-z. Epub 2020 Apr 22. Download PDF file.

Winston,  A. H., Haddon,D.J., Diep, V.K., Avani Khatri, A., Bongen, E., Yiu,G., Balboni, I., Bolen, C.R., Mao, R., Utz, P.J., and Purvesh Khatri, P., 2020. Integrated, multicohort analysis reveals unified signature of systemic lupus erythematosus. JCI Insight. 2020;5(4):e122312. https://doi.org/10.1172/jci. insight.122312. Download PDF file.

2019

Bongen E., Lucian, H., Khatri, A., Fragiadakis, G.K., Bjornson, Z.B.,  Nolan, G.P.,  Utz, P.J.,  and Khatri, P., 2019. Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection. Cell Rep. 29:1961-1973.e4. PDF.

Ruiz-Romero, C., Lam, M.P.Y., Nilsson P., Önnerfjord, P. , Utz, P.J., Van Eyk, J.E., Venkatraman,V.,  Fert-Bober, J., Wattand, F.E., and Blanco, F.J., 2019. Mining the Proteome Associated with Rheumatic and Autoimmune Diseases. J Proteome Res. 18:4231-4239. Download PDF file.

James, J.A., Guthridge, J.M., Chen, H.,  Lu, R., Bourn, R.L., Bean, K., Munroe, M.E., Smith, M., Chakravarty, E., Baer, A.N., Noaiseh, G.,  Parke, A., Boyle, K., Keyes-Elstein, L., Coca, A. Utset, T.,  Genovese, M.C., Pascual, V., Utz, P.J.,  Holers, V.M., Deane, K.D., Sivils, K.L., Aberle, T., Wallace, D.J., McNamara, J., Franchimont, N., and St Clair, E.W., 2019. Unique Sjögren's syndrome patient subsets defined by molecular features. Rheumatology (Oxford). 2019 Sep. Download PDF file.

Steinman, L., Ho, P.P., Robinson, W.H., Utz, P.J., and Villoslada, P., 2019.  Antigen-specific tolerance to self-antigens in protein replacement therapy, gene therapy and autoimmunity. Curr Opin Immunol. 2019 Aug 30;61:46-53. doi: 10.1016/j.coi.2019.07.011. PDF.

Jain, M.K., Cheung, V.G., Utz, P.J., Kobilka, B.K., Yamada, T., and Lefkowitz, R., 2019. Saving the Endangered Physician-Scientist - A Plan for Accelerating Medical Breakthroughs. N Engl J Med.381:399-402. PDF.

Arazi, A., Rao, D.A., Berthier, C.C., Davidson, A., Liu, Y., Hoover, P.J., Chicoine, A., Eisenhaure, T.M., Jonsson, A.H.,  Li, S., Lieb, D.K.,  Zhang, F., Slowikowski, K., Browne, E.P., Noma, A., Sutherby, D., Steelman, S., Smilek, D.E., Tosta, P.,  Apruzzese, W.,  Massarotti, E.,  Dall'Era, M., Park, M.,  Kamen, D.L., Furie, R.A., Payan-Schober, F.,  Pendergraft, W.F., 3rd, McInnis, E.A., Buyon, J.P., Petri, M.A., Putterman, C., Kalunian, K.C., Woodle, E.S., Lederer, J.A., Hildeman, D.A., Nusbaum, C., Raychaudhuri, S., Kretzler, M., Anolik, J.H., Brenner, M.B., Wofsy, D., Hacohen, N., and Diamond, B., 2019.  Accelerating Medicines Partnership in SLE network, 2019. The immune cell landscape in kidneys of patients with lupus nephritis. Nat Immunol. 20:902-914. PDF.

Cheung, P., Khatri, P., Utz, P.J., and Kuo, A.J., 2019. Single-cell technologies - studying rheumatic diseases one cell at a time. Nat Rev Rheumatol. 15:340-354. PDF.

Zhang F., Wei, K., Slowikowski, K., Fonseka, C.Y., Rao, D.A., Kelly, S., Goodman, S.M., Tabechian, D., Hughes, L.B., Salomon-Escoto,  K., Watts, G.F.M., Jonsson, A.H., Rangel-Moreno, J., Meednu, N., Rozo, C., Apruzzese, W., Eisenhaure, T.M., Lieb, D.J., Boyle, D.L., Mandelin, A.M., 2nd, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Boyce, B.F.,  DiCarlo, E.,  Gravallese, E.M., Gregersen, P.K., Moreland, L., Firestein, G.S., Hacohen, N., Nusbaum, C., Lederer, J.A., Perlman, Pitzalis, H.C.,  Filer, A., Holers, V.M., Bykerk, V.P., Donlin, L.T., Anolik, J.H., Brenner, M.B., and Raychaudhuri, S., 2019. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nat Immunol. 20:928-942. PDF.

Sng, J., B. Ayoglu, J.W. Chen, J.N. Schickel, E.M.N. Ferre, S. Glauzy, N. Romberg, M. Hoenig, C. Cunningham-Rundles, P.J. Utz, M.S.L ionakis, and E. Meffre, 2019. AIRE expression controls the peripheral selection of autoreactive B cells. Sci Immunol. 4(34). pii: eaav6778. doi: 1. PDF.

Christophersen, A, Lund, E.G., Snir, O., Solà, E., Kanduri, C., Dahal-Koirala, S., Zühlke, S.,  Molberg, Ø., Utz, P.J., Rohani-Pichavant, M., Simard, J.F., Dekker, J.L., Lundin, K.E.A.,Sollid, L.M. and Davis, M.M., 2019. Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions. Nat Med. 25:734-737. PDF.

Slight-Webb, S., J.M. Guthridge, E.F. Chakravarty, H. Chen, R. Lu, S. Macwana, K. Bean K, H.T.  Maecker, P.J. Utz, J.A. James, 2019. Mycophenolate mofetil reduces STAT3 phosphorylation in systemic lupus erythematosus patients. JCI Insight. 24;4(2). pii: 124575. doi: 10.1172/jci.insight.124575. PDF.

Ravi, N., Rizzi, G., Chang, S.E., Cheung, P., Utz, P.J., and Wang, S.X., 2019. Quantification of cDNA on GMR biosensor array towards point-of-care gene expression analysis. Biosens Bioelectron. 130:338-343. PDF.

2018

Cheung, P., Vallania. F., Dvorak, M.,  Chang, S.E., Schaffert, S., Donato, M., Rao, A.M., Mao, R., Utz, P.J., Khatri, P., and A.J. Kuo, 2018. Single-cell epigenetics – Chromatin modification atlas unveiled by mass Tcytometry. Clin Immunol. 196:40-48. PDF.

Donlin L.T., Rao, D.A., Wei, K., Slowikowski, K., McGeachy, M.J., Turner, J.D., Meednu, N., Mizoguchi, F., Gutierrez-Arcelus, M., Lieb, D.J., Keegan, J., Muskat, K., Hillman, J., Rozo, C., Ricker, E., Eisenhaure, T.M., Li, S., Browne, E.P.,  Chicoine, A., Sutherby, D., Noma, A., Accelerating Medicines Partnership RA/SLE Network, Nusbaum, C., Kelly, S.,  Pernis, A.B.,  Ivashkiv, L.B., Goodman, S.M., Robinson, W.H., Utz, P.J., Lederer, J.A., Gravallese, E.M., Boyce, B.F., Hacohen, N., Pitzalis, C., Gregersen, P.K.,  Firestein, G.S., Raychaudhuri, S., Moreland,L.M., Holers, V.M., Bykerk, V.P., Filer, A., Boyle, D.L., Brenner, M.B., and J.H. Anolik, 2018. Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue. Arthritis Res Ther. 2018 Jul 11;20(1):139. PDF. 

Bongen, E., F. Vallania, P.J. Utz and P. Khatri, 2018. KLRD1 -expressing natural killer cells predict influenza susceptibility. Genome Medicine 10 :45. PDF .

Cheung, P., FrancescoV.,  Warsinske H.C., M. Donato, S. Schaffert, S.E. Chang, M. Dvorak, C.L. Dekker, M.M. Davis, P.J. Utz, P. Khatri, and A.J. Kuo1, 2018. Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging. Cell. 173:1-13. PDF.

2017

Maccari, M.-E., Scarselli, A., Di Cesare, S., Floris, M., Angius, A., Deodati, A., Chiriaco, M., Cambiaso, P., Corrente, S., Colafati, G.S., Utz, P.J., Angelini, F., Fierabracci, A., Aiuti, A., Carsetti, R., Rosenberg, J.M., Cappa, M., Rossi, P., Bacchetta, R., Cancrina, C., 2017. Severe Toxoplasma gondii infection in a member of a NFKB2-deficient family with T and B cell dysfunction. Clin. Immunology 183: 273-277. PDF.

Haddon, D.J., Wand, H.E., Jarrell, J.A., Spiera, R.F., Utz, P.J., Gordon, J.K., Chung, L.S., 2017. Proteomic Analysis of Sera from Individuals with Diffuse Cutaneous Systemic Sclerosis Reveals a Multianalyte Signature Associated with Clinical Improvement during Imatinib Mesylate Treatment. J. Rheumatology . 44 :631-638. PDF.

Degn, S.E., van der Poel, C.E., Firl, D.J., Ayoglu, B., Al Qureshah, F.A., Bajic, G., Mesin, L., Reynaud, C.A., Weill, J.C., Utz, P.J., Victora, G.D., Carroll, M.C., 2017. Clonal Evolution of Autoreactive Germinal Centers.. Cell 170(5):913-926.e19. PDF.

Perkins, T., Rosenberg, J.M., Le Coz, C., Alaimo, J.T., Trofa, M., Mullegama, S.V., Antaya, R.J., Jyonouchi, S., Elsea, S.H., Utz, P.J., Meffre, E., Romberg, N., 2017. Smith-Magenis Syndrome Patients Often Display Antibody Deficiency but Not Other Immune Pathologies Allergy. Clin Immunol Pract. 5:1344-1350.e3. PDF.

Lee, J.R., Haddon, D.J., Gupta, N., Price, J.V., Credo, G.M., Diep, V.K., Kim, K., Hall, D.A., Baechler, E.C., Petri, M., Varma, M., Utz, P.J., Wang, S.X., 2017. High-Resolution Analysis of Antibodies to Post-Translational Modifications Using Peptide Nanosensor Microarrays. ACS Nano. 10:10652-10660. PDF.

2016

Lofgren, S., Hinchcliff, M., Carns,  Wood, M., Aren, T., Arroyo, K., Cheung, P., Kuo, A., Valenzuela, A., Haemel, A., Wolters, P.J., Gordon, J., Spiera, R., Assassi, S., Boin,F., Chung, L., Fiorentino, D., Utz, P.J., Whitfield, M.L., Khatri, P., 2017. Integrated, multicohort analysis of systemic sclerosis identifies robust transcriptional signature of disease severity. JCI Insight. 1:e89073. PDF.

Choi, J., Gani, A.W., Bechstein, D.J.B., Lee, J.R., Utz, P.J., Wang, S.X., 2016. Portable, one-step, and rapid GMR biosensor platform with smartphone interface. Biosens Bioelectron. 85:1-7. PDF.

Walter, J.E., Rosen, L.B., Csomos, K., Rosenberg, J.M., Mathew, D., Keszei, M., Ujhazi, B., Chen, K., Lee, Y.N., Tirosh, I., Dobbs, K., Al-Herz, W., Cowan, M.J., Puck, J., Bleesing, J.J., Grimley, M.S., Malech, H., De Ravin, S.S., Gennery, A.R., Abraham, R.S., Joshi, A.Y., Boyce, T.G., Butte, M.J., Nadeau, K.C., Balboni, I., Sullivan, K.E., Akhter, J., Adeli, M., El-Feky, R.A., El-Ghoneimy, D.H., Dbaibo, G., Wakim, R., Azzari, C., Palma, P., Cancrini, C., Capuder, K., Condino-Neto, A., Costa-Carvalho, B.T., Oliveira, J.B., Roifman, C., Buchbinder, D., Kumanovics, A., Franco, J.L., Niehues, T., Schuetz, C., Kuijpers, T., Yee, C., Chou, J., Masaad, M.J., Geha, R., Uzel, G., Gelman, R., Holland, S.M., Recher, M., Utz, P.J., Browne, S.K., Notarangelo, L.D., 2016. Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. J Clin Invest. 126(11):4389. PDF.

Slight-Webb, S., Lu, R,. Ritterhouse, L.L., Munroe, M.E., Maecker, H.T., Fathman, C.G., Utz, P.J., Merrill, J.T., Guthridge, J.M., James, J.A., 2016. Autoantibody-Positive Healthy Individuals Display Unique Immune Profiles That May Regulate Autoimmunity. Cell Rep. 16, 717-730. PDF.

Lee, J.R., Haddon, D.J., Wand, H.E., Price, J.V., Diep, V.K., Hall, D.A., Petri, M., Baechler, E.C., Balboni, I.M., Utz, P.J., Wang, S.X., 2016. Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus. Sci Rep. 6:27623. PDF.

Kim, J.H., Furrow, E., Ritt, M.G., Utz, P.J., Robinson, W.H., Yu, L., Eckert, A., Stuebner, K., O'Brien, T.D., Steinman, L., Modiano, J.F., 2016. Development of Th17-Associated Interstitial Kidney Inflammation in Lupus-Prone Mice Lacking the Gene Encoding STAT-1. PLoS ONE11 : PDF.

Revelo, X.S., Ghazarian, M., Chng, M.H., Luck, H., Kim, J.H., Zeng, K., Shi, S.Y., Tsai, S., Lei, H., Kenkel, J., Liu, C.L., Tangsombatvisit, S., Tsui, H., Sima, C., Xiao, C., Shen, L., Li, X., Jin, T., Lewis, G.F., Woo, M., Utz, P.J., Glogauer, M., Engleman, E., Winer, S., Winer, D.A., 2016. Nucleic Acid-Targeting Pathways Promote Inflammation in Obesity-Related Insulin Resistance. Cell Rep. 16 :717-30. PDF .

Yu, C., Burns, J.C., Robinson, W.H., Utz, P.J., Ho, P.P., Steinman, L., Frey, A.B., 2016. Identification of Candidate Tolerogenic CD8(+) T Cell Epitopes for Therapy of Type 1 Diabetes in the NOD Mouse Model. J Diabetes Res. 2016 :9083103. PDF.

Rosenberg, J.M., Price, J.V., Barcenas-Morales, G., Ceron-Gutierrez, L., Davies, S., Kumararatne, D.S., Döffinger, R., Utz, P.J., 2016. Protein microarrays identify disease-specific anti-cytokine autoantibody profiles in the landscape of immunodeficiency. J Allergy Clin Immunol. 137:204-213.e3. PDF.

2015

Yiu, G., Rasmussen, T.K., Ajami, B., Haddon, D.J., Chu, A.D., Tangsombatvisit, S., Haynes, W.A., Diep, V., Steinman, L., Faix, J., Utz, P.J., 2015. Development of Th17-Associated Interstitial Kidney Inflammation in Lupus-Prone Mice Lacking the Gene Encoding STAT-1. Arthritis and Rheumatol. 68 :1233-1244. PDF.

Chakravarty, E.F., V. Martyanov, D. Fiorentino, T.A. Wood, D.J. Haddon, J.A. Jarrell, P.J. Utz, M.C. Genovese, M.L. Whitfield and L. Chung, 2015. Gene expression changes reflect clinical response in a placebo-controlled randomized trial of abatacept in patients with diffuse cutaneous systemic sclerosis. Arthiritis Research and Therapy 17 :159. PDF.

Haddon, D.J., V.K. Diep, J.V. Price, C. Limb, P.J. Utz and I. Balboni, 2015. Autoantigen microarrays reveal autoantibodies associated with proliferative nephritis and active disease in pediatric systemic lupus erythematosus. Arth. Res. Ther. 17 :162. PDF.

Haddon, D.J., J.A. Jarrell, M.R. Hughes, K. Snyder, K.M. McNagny, M.G. Kattah, and P.J. Utz, 2015. Measurement of Mast Cell Surface Molecules By High-Throughput Immunophenotyping Using Transcription (HIT). Methods in Molecular Biology. 1220 :381-400. PDF.

Kattah, N.H., E.W. Newell, J.A. Jarrell, A,D. Chua, J. Xie, M.G. Kattah, O, Goldberger, J, Ye, E. F. Chakravarty, M.M. Davis, and P.J. Utz, 2015. Tetramers reveal IL-17–secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease. PNAS 112 : 3044-3049. PDF.

Nguyen, L.X.T., Y. Lee, L. Urbani, P.J. Utz, A.W. Hamburger, J.B. Sunwoo, and B.S. Mitchell, 2015. Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1. Blood 125: 2519-2529. PDF.

O'Gorman, W.E., E.W. Y. Hsieh, E.S. Savig, P.F. Gherardini, J.D. Hernandez, L. Hansmann, I.M. Balboni, P.J. Utz, S.C. Bendall, W.J. Fantl, D.B. Lewis, G.P. Nolan, and M.M. Davis, 2015. Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus. J. Allergy and Clinical Immunology. In Press. PDF.

Rasmussen, T.K., T. Andersen, R.O. Bak, G. Yiu, C.M. Sørensen, K. Stengaard-Pedersen, J.G. Mikkelsen, P.J. Utz, C.K. Holm and B. Deleuran, 2015. Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus. Arthritis Research & Therapy 17 : 154. PDF.

Rosenberg, J. and P.J. Utz, 2015. Protein arrays: a new tool for the study of autoantibodies in immunodeficiency. 2015. Frontiers in Immunology, 6 :138. PDF.

Haddon, D.J., Jarrell, J.A., Diep, V.K., Wand, H.E., Price, J.V., Tangsombatvisit, S., Credo, G.M., Mackey, S., Dekker, C.L., Baechler, E.C., Liu, C.L., Varma, M., Utz, P.J., 2015. Mapping epitopes of U1-70K autoantibodies at single-amino acid resolution. Autoimmunity. 48 :513-23. PDF.

2014

Kinloch, A.J., A. Chang, K. Ko, C..J.H. Dunand, S. Henderson, D. Brandt, M. Maienschein-Cleine, N. Kaverina, B. Robin, M.S. Ferrer, D. Wlfgeher, V. Liarski, D.J. Haddon, P.J. Utz, P.C. Wilson and M.R. Clark, 2014. Vimentin is a dominant target of in situ humoral immunity in human lupus tubulointerstitial nephritis. Arthritis and Rheumatol. 66:3359-3370. PDF.

Tang, X., B. Zhang, J.A. Jarrell, J.V. Price, H. Dai, P.J. Utz PJ and S. Strober, 2014. Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice. J. Autoimmunity. 50: 87-98. PDF.

2013

Balboni, I., T.B. Niewold, G. Morgan, C. Limb, M.L. Eloranta, L. Rönnblom, P.J. Utz, L.M. Pachman, 2013, Interferon-α induction and detection of anti-ro, anti-la, anti-sm, and anti-rnp autoantibodies by autoantigen microarray analysis in juvenile dermatomyositis. Arthritis Rheum. 65:2424-9. PDF.

Chruscinski, A.J., H. Singh, S.M. Chan and P.J. Utz, 2013. Broad-scale phosphoprotein profiling of beta adrenergic receptor (β-AR) signaling reveals novel phosphorylation and dephosphorylation events. PLoS One 5 :e82164. PDF.

Furman, D., V. Jojic, B. Kidd, S. Shen-Orr, J. Price, J. Jarrell, T. Tse, H. Huang, P. Lund, H.T. Maecker, P.J. Utz, C.L. Dekker, D. Koller and M.M. Davis, 2013. Apoptosis and other immune biomarkers predict influenza vaccine responsiveness. Mol Syst Biol . 9:659. PDF . Erratum in Mol Syst Biol. 2013;9:680 .

Gottlieb, P., P.J. Utz, W. Robinso and L. Steinman, 2013. Clinical optimization of antigen specific modulation of type 1 diabetes with the plasmid DNA platform. Clin Immuno l. 149:297-306. PDF.

Haddon, D.J., J.A. Jarrell, M.R. Hughes, K. Snyder, K.M. McNagny, M.G. Kattah, P.J. Utz, 2013. Book Chapter: Measurement of mast cell surface molecules using high-throughput immunophenotyping using transcription (HIT), in MAST Cells: Methods and Protocols. Humana Press.

Price, J.V., D.J. Haddon, D. Kemmer, G. Delepine, G. Mandelbaum , J.A. Jarrell, R. Gupta, I. Balboni, E.F. Chakravarty, J. Sokolove, A.K. Shum, M.S. Anderson, M.H. Cheng,W.H. Robinson, S.K. Browne, S.M. Holland, E.C. Baechler and P.J. Utz. Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus. J. Clin. Invest. 123:5135-45. PDF.

Price, J.V., J.A. Jarrell, D. Furman, N.H. Kattah, E. Newell, C.L. Dekker, M.N. Davis and P.J. Utz , 2013. Characterization of influenza vaccine immunogenicity using influenza antigen microarrays. PLoS One . 5:e64555. PDF.

Roep, B.P., N. Solvason, P.A. Gottlieb, J.R. Abreu, L.C. Harrison, G.S. Eisenbarth, L.Yu, M. Leviten, W.A. Hagopian, J.B. Buse, M. von Herrath, J. Quan, R.S. King, W.H. Robinson, P.J. Utz, H. Garren, BHT-3021 Investigators and L. Steinman, 2013. Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8? T cells in type 1 diabetes. Sci Transl Med. 5:191ra82. PDF . Supplemental Material.

Zhang, B., J. Price, G. Hong, S.M. Tabakman, H. Wang, J.A. Jarrell, J. Feng, P.J. Utz and H. Dai, 2013. Multiplexed cytokine detection on plasmonic goldsubstrates with enhanced near-infrared fluorescence. Nano Research. PDF Epub ahead of publication.

Zhang, B., J.A. Jarrell, J.V. Price, S.M. Tabakman, Y. Li, M. Gong, G. Hong, J. Feng, P.J. Utz and H. Dai, 2013. An integrated peptide-antigen microarray on plasmonic gold films for sensitive human antibody profiling. PLoS One 8: e71043. PDF.

2012

Junttila, I.S., R.J. Creusot, D.L. Bates, I. Moraga, P. Lupardus, P.J. Utz, C.G. Fathman, W.E. Paul, K.C. Garcia, 2012. Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines. Nature Chemical Biology. 8:990-998. (See News and Views Article ) PDF.

Landrigan, A., G. Yiu, K. Agarwal and P.J. Utz, 2012.Therapeutic Toll-like receptor agonists directly influence mouse and human T cell lymphoma cell viability and cytokine secretion. Leukemia & Lymphoma . 54:166-168. PDF.

Lin, J.T., E.A. Stein, M.T. Wong, K.J. Kalpathy L.L. Su, P.J. Utz, W.H. Robinson and C.G. Fathman, 2012. Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis. Clinical Immunology . 142(2):127-38. PDF.

Liu, C.L.L., S. Tangsombatvisit, J.M. Rosenberg, G. Mandelbaum, E.C. Gillespie, O.P. Gozani, A.A. Alizadeh and P.J. Uz, 2012. Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies. Arthritis Research & Therapy , 14:R25. PDF Correction.

Maecker, H.T., T.M. Lindstrom, W.H. Robinson, P.J. Utz, M. Hale, S.D. Boyd, S.S. Shen-Orr, and C.G. Fathman, 2012. New tools for the classification and monitoring of autoimmune diseases. Nat. Rev. Rheumatol. 8:317-328. PDF.

Price, J.V., S. Tangsombatvisit, G. Xu, J. Yu, D. Levy, E.C. Baechler, O. Gonzani, M. Varma, P.J. Utz and C.L. Liu, 2012. On silico peptide microarrays for high-resolution mapping of antibody epitopes and diverse protein-protein interactions. Nature Medicine. PDF.

Teo, P.Z., P.J. Utz, J.A. Mollick, 2012. Using the allergic immune system to target cancer: activity of IgE antibodies specific for human CD20 and MUC1. Cancer Immunol Immunother . 2012 Jun 13. PDF.

2011

Alonso, M.N., M.T. Wong, A.L. Zhang, D. Winer, M.M. Suhoski, L.L. Tolentino, J. Gaitan, M.G. Davidson, T.H. Kung, D.M. Galel, K.C. Nadeau, J. Kim, P.J. Utz, K. Söderström and E.E. Engleman, 2011. TH1, TH2 and TH17 cells instruct monocytes to differentiate into specialized dendritic cell subsets. Blood . 118:3311-3320. PDF.

Cheung, R.K., and P.J. Utz, 2011. Screening: CyTOF-the next generation of cell detection. Nat. Rev. Rheumatol. 7:502-503. PDF.

Landrigan, A., M.T. Wong and P.J. Utz, 2011. CpG- and non-CpG oligodeoxynucleotides directly activate T cells through a TLR9- and MyD88-independent mechanism. J. Immunol. , Aug. 15, 2011. PDF.

Levy, D., C.L.L. Chin, Z. Yang, A. M. Newman, A.A. Alizadeh, P.J .Utz and O. Gozani, 2011. A proteomic approach for the identification of novel lysine methyltransferase substrates. Epigenetics & Chromatin 4:19-30. PDF.

Levy, D., A.J. Kuo, Y. Chang, U. Schaefer, C. Kitson, P. Cheung, A. Espejo, B.M. Zee, C.L. Liu, S. Tangsombatvisit, R.I. Tennen, A.Y. Kuo, S. Tanjing, R. Cheung, K.F. Chua, P.J. Utz, X. Shi, R.K. Prinjha, K. Lee, B.A. Garcia, M.T. Bedford, A. Tarakhovsky, X. Cheng and O. Gozani, 2011. Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nature Immunology. 12:29-36. PDF.

Qin, H, I.-F. Lee, C. Panagiotopoulos, X. Wang, A.D. Chu, P.J. Utz, J.J. Priatel and R. Tan, 2011. Natural killer cells from children with type 1 diabetes have defects in NKG2D-dependent function and signaling. Diabetes 60:857-866. PDF.

Singh, H., K.A. Henry, S.S.T. Wu, A. Chruscinski, P.J. Utz and J.K. Scott, 2011. Reactivity profiles of broadly neutralizing anti-HIV-1 antibodies are distinct from those of pathogenic autoantibodies. AIDS, 25:1247-1346. PDF.

Tabakman, S.D., L. Lau, J.T. Robinson, J. Price, S.P. Sherlock, H. Wang, B. Zhang, Z. Chen, S. Tangsombatvisit, J.A. Jarrell, P.J. Utz and H. Dai, 2011. Plasmonic substrates for multiplexed protein microarrays with femtomolar sensitivity and broad dynamic range. Nature Commications. 2: Article Number 466. PDF.

Woo, S.R., M.E. Turnis, M.V. Goldberg, J. Bankoti, M. Selby, C.J. Nirschl, M.L. Bettini, D.M. Gravano, P. Vogel, C.L. Liu, S. Tangsombatvisit, J.F. Grosso, G. Netto, M.P. Smeltzer, A. Chaux, P.J. Utz, C.J. Workman, D.M. Pardoll, A.J. Korman, C.G. Drake and D.A. Vignali, 2012. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res 72:917-927. PDF.

2010

Graham, K., L. Lee, J. Higgins, P.J. Utz, L. Steinman and P. Ho, 2010. Treatment with a toll-like receptor inhibitory GpG oligonucleotide delays and attenuates lupus nephritis in NZB/W mice. Autoimmunity 43:140-155. PDF.

Kattah, N.H., M.G. Kattah, P.J. Utz, 2010. The U1-snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases. Immunol. Rev . 233:126-145. PDF.

Richez, C., K. Yasuda, R.G. Bonegio, AA.Watkins, T. Aprahamian, P. Busto, R.J. Richard, C.L. Liu, R. Cheung, P.J. Utz, A. Marshak-Rothstein and I.R. Rifkin, 2010. IFN regulatory factor 5 is required for disease development in the FcγRllB-/-Yaa and FcγRllB-/- mouse models of systemic lupus erythematosus. J. Immunol. 184:796-806. PDF.

Tavares, R.M., E.E. Turer, C.L. Liu, R. Advincula, P. Scapini, L. Rhee, J. Barrera, ClA. Lowell, P.J. Utz, B.A. Malynn and A. Ma, 2010. The Ubiquitin Modifying Enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity , 33:181-191. PDF.

Wong, M., J. Ye, E.E. Engleman and P.J. Utz, 2010. Regulation of human Th9 differentiation by type I interferons and IL-21. Immunology and Cell Biology. 88:624-632. PDF.

2009

Lin, J.T., N.B. Lineberry, M.G. Kattah, L.L. Su, P.J. Utz, C.G. Fathman, L. Wu, 2009. Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAILexpression. J Immunol. 182: 5919-5928. PDF.

Thibault, D.L. K.L. Graham, L.V. Lee, I. Balboni, P.J. Hertzog and P.J. Utz, 2009. Type I IFN receptor controls B cell expression of nucleic acid sensing toll-like receptors and autoantibody production in a murine model of lupus. Arthritis Res Ther. 11: R112. PDF.

Wu,, J.C., A. Chruscinski, V.A. De Jesus Perez, H. Singh, M. Pitsiouni, M. Rabinovitch, P.J. Utz and J.P. Cooke, 2009. Cholinergic modulation of angiogenesis: Role of the 7 nicotinic acetylcholine receptor. J Cell Biochem. 2009 Jul 21. PDF.

2008

Balboni, I., C. Limb, J.D. Tenenbaum, P.J. Utz, 2008. Evaluation of microarray surfaces and arraying parameters for autoantibody profiling. Proteomics. 8: 3443-3449. PDF.

Chen, Z., S.M. Tabakman, A.P. Goodwin, M.G. Kattah, D. Daranciang, X. Wang, G., Zhang, X. Li, Z. Liu, P.J. Utz, K. Jiang, S. Fan and H. Dai, 2008. Protein microarrays with carbon nanotubes as multicolor Raman labels. Nat. Biotechnology. 26: 1285-92. Epub 2008 Oct. 26. PDF.

Drouvalakis, K.A., S. Bangsaruntip, W. Hueber, L.G. Kozar, P.J. Utz, H. Dai, 2008. Peptide-coated nanotube-based biosensor for the detection of disease-specific autoantibodies in human serum. Biosensors and Bioelectronics . 23:1413-1421. PDF.

Garren, H., W.H. Robinson, E. Krasulova´, E Havrdova´, C. Nadj, K. Selmaj, J. Losy, I. Nadj, E.-W. Radue, B.A. Kidd, J. Gianettoni, K. Tersini, P.J. Utz, F. Valone, L. Steinman, and the BHT-3009 Study Group, 2008. Phase 2 Trial of a DNA Vaccine Encoding Myelin Basic Protein for Multiple Sclerosis. Ann. Neurol. 63: 611-620. PDF.

Graham, K.L., L.Y. Lee, J.P. Higgins, L. Steinman L, P.J. Utz and P.P. Ho, 2008. Failure of oral atorvastatin to modulate murine model of systemic lupus erythematosus. Arthritis Rheum. 58:2098- 2104. PDF.

Holst J., H. Wang, K.D. Eder, C.J. Workman, K.L. Boyd, Z. Baquet, H. Singh, K. Forbes, A. Chruscinski, R. Smeyne, N.S. van Oers, P.J. Utz, D.A. Vignali, 2008. Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimunity. Nature Immunology . 9:658-666. PDF.

Kattah, M.G., J. Coller, R.K. Cheung, N. Oshidary, P.J. Utz PJ., 2008. HIT: a versatile proteomics platform for multianalyte phenotyping of cytokines, intracellular proteins and surface molecules. Nat Med . 14: 1284-1289. Epub 2008 Oct 12. PDF

Kattah, MG, MT Wong, MD Yocum, PJ Utz, 2008. Cytokines secreted in response toTLF-ligand stimulation modulate IL-1induced TH -17 differentiation. Arthritis Rheum. 58:1619-1629. PDF.

Kattah, MG, PJ Utz, I Balboni. Editorial: Protein microarrays address the elephant in the room. Clin Chem. 54:937-939. PDF.

Li, D.H., M.M. Winslow, T.M. Cao, A.H. Chen, C.R. Davis, E.D. Mellins, P.J. Utz, G.R. Crabtree, J.R. Parnes. 2008. Arthritis Rheum. 58: 1285-1292. PDF.

Tenenbaum, J.D., M.G. Walker1, P.J. Utz and A.J. Butte, 2008. Expression-based Pathway Signature Analysis (EPSA): Mining publicly available microarray data for insight into human disease. BMC Med. Genomics. 1 :51-62. PDF.

Thibault, D.L., A.D. Chu, K. L. Graham, I. Balboni, L.Y. Lee, C. Kohlmoos, A, Landrigan, J.P. Higgins, R. Tibshirani, and P.J. Utz, 2008. IFR9 and STAT1 are require for IgG autoantibody production and B-cell expression of TLR7 in mice. J. Clin. Invest.118: 1417-26. PDF.

2007

Bar-Or, A., Vollmer, T., Antel, J., Arnold, D.L., Bodner, C.A., Campagnolo, D., Gianettoni, J., Jalili, F.,Kachuck, N., Lapierre, Y., Niino, M., Oger, J., Price, M., Rhodes, S., Robinson, W.H., Shi, F.-D., Utz, P.J., Valone, F., Weiner, L., Steinman, L., Garren, H. Induction of Antigen-Specific Tolerance in Multiple Sclerosis After Immunization With DNA Encoding Myelin Basic Protein in a Randomized, Placebo-Controlled Phase 1/2 Trial. Arch. Neurol. 2007;64:E1-E9. PDF.

Chan, S.M., A.P. Weng, R. Tibshirani, J.C. Aster and P.J. Utz, 2007. Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia. Blood . 110:278-286. PDF.

Matthews, A.G., A.J. Kuo, S. Ramón-Maiques, S. Han, K.S. Champagne, D. Ivanov, M. Gallardo, D. Carney, P. Cheung, D.N. Cicone, K.L. Walkter, P.J. Utz, Y. Shi, T.G. Kutateladzem, W. Yang, O. Gozani and M.A. Oettinger, 2007. RAG2 PHD finger couples histone He lysine 4 trimethylation with V(D)J recomb ination. Nature . 450:1106-1110. PDF.

Pennathur S., F. Baldessari, M.G. Kattah, P.J. Utz and J.G. Santiago, 2007. Free-solution oliogonucleotide seperation in nanoscale channels. Anal. Chem. 79:8316-8322. PDF.

Sharpe, V. and P.J. Utz, 2007. Technology Insight: can autoantibody profiling improve clinical practice? Nature Clinical Practice. 3: 96-103. PDF.

Shi, X., I. Kachirskaia, K.L. Walker, J.H. Kuo, A. Lake, F. Favrazou, S.M. Chan, D.G. Martin, I.M. Fingerman, S.D. Briggs, L. Howe, P.J. Utz, T.G. Kutateladze, A.A. Lugovskoy, M.T. Bedford, O. Gozani, 2007. Proteome-wide analysis in Sacchromyces cerevisiae identifies several PHD fingers as novel direct and selective modules of histone H3 methylated at either lysine 4 or lysine 36. Journl of Biological Chemistry. 282:2450-55. PDF.

2006

Balboni I., S.M. Chan, M. Kattah, J.D. Tenenbaum, A.J. Butte and P.J. Utz. Multiplexed protein array platforms for analysis of autoimmune diseases. In: Annual Review of Immunology, W. Paul, C.G. Fathman, L.H. Glimcher (Eds), pps. 391-418, Vol. 24, 2006. PDF.

Chan SM, J. Olsen, P.J. Utz. Single-cell analysis of siRNA-mediated gene silencing using multiparameter flow cytometry. Cytometry . 2006. 69A(2):59-65. PDF.

Graham, K.L., M. Vaysberg, A. Kuo and P. J. Utz, 2006. Autoantigen arrays for multiplex analysis of antibody isotypes. Proteomics 2006, 6:5720–5724. PDF.

Kattah M.G., G.R. Alemi, D.L. Thibault and P.J. Utz. A novel two-color fab labeling method for autoantigen protein microarrays. Nature Methods . 2006.3:745-751. PDF.

Paniagua RT, P Sharpe, PP Ho, SM Chan, A Chang, JP Higgins, BH Tomooka, FM Thomas, JJ Song, SB Goodman, MC Genovese, PJ Utz, L STeinman, WR Robinson, 2006. Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of rheumatoid arthritis. J. Clin. Invest. 115:2633-2642. PDF.

Sekine H., K. L. Graham, S. Zhao, M.K. Elliott, P. Ruiz, L. Morel, V. M. Holers, P.J. Utz and G. S. Gilkeson. Role of MHC-linked genes in autoantigen selection and renal disease in a murine model of SLE. J. Immunol. 2006. 177:7423-7434. PDF.

2005

Chan S.M. and P.J. Utz, 2005. The challenge of analyzing the proteome in humans with autoimmune diseases. Ann. NY Acad. Sci . 1062:61-68. PDF.

Fathman, C.G., L. Soares, S.M. Chan and P.J. Utz., 2005. An array of possibilities for the study of autoimmunity. Nature 435:605-611. PDF.

Graham K.L., D. L. Thibault, M. Kamachi, S. Zhao, J. Steinman, L. Okeke, P. N. Kao and P.J. Utz., 2005. Granzyme B is dispensable for immunological tolerance to self in a murine model of systemic lupus erythematosus. Arth. Rheum . 52:1684-1693. PDF.

Graham K.L. and P.J. Utz, 2005. Sources of autoantigens in systemtic lupus erythematosus. Curr. Opin. Rheumatol. 17:513-517. PDF.

Huang, M., H. Ida, M. Kamachi, N. Iwanaga, Y. Izumi, F. Tanaka, K. Aratake, K. Arima, M. Tamai, A. Hida, H. Nakamura, T. Origuchi, A. Kawakami, N. Ogawa, S. Sugai, P.J. Utz and K. Eguchi, 2005. Detection of apoptosis-specific autoantibodies directed against granzyme B-induced cleavage fragments of the SS-B (La) autoantigen in sera from patients with primary Sjögren’s Syndrome. Clin. Exp. Immunol. 42:148-154. PDF.

Hueber W., B.A. Kidd, B.H. Tomooka, B.J. Lee, B. Bruce, J.L. Fries, G. Sonderstrup, P. Monach, J.W. Drijfhout, W.J. van Venrooij, P.J. Utz, M.C. Genovese and W.H. Robinson, 2005. Antigen microarray profiling of autoantibodies in rheumatoid arthritis. Arthritis Rheum . 52:2645-55. PDF.

Huston D.P., C.G. Fathman and P.J. Utz, 2005. Fostering interdisciplinary immunology. Clin. Immunol. 115:1-2. PDF.

Ida I., P.J. Utz, P. Anderson and K. Eguchi, 2005. Granzyme B and natural killer (NK) death. Mod. Rheumtol. 2005. 15:315-322. PDF.

Steinman L., P.J.Utz and W.H. Robinson, 2005. Suppression of autoimmunity via microbial mimics of altered peptide ligands. Curr Top Microbiol Immunol. 296:55-63. PDF.

Utz, P.J., 2005. Protein arrays for studying blood cells and their secreted products. Immunol. Rev . 2005. 204:264-282. PDF.

2004

Chan, S.M., J. Ermann, L. SU, C.G. Fathman and P.J. Utz, 2004. Protein Microarrays for Multiplex Analysis of Signal Transdaucton Pathways. Nature Medicine. 10:1390-1396. Supporting Documents: Raw Data (Excel Format), Antibody Sources (Excel), Lysis Buffer Recipe (Word Format), Reverse Phase Microarray Protocol (Word Format). PDF.

Chung L. and P.J. Utz, 2004. Autoantibodies in scleroderma: Direct pathogenicity and phenotypic associations. Curr. Rheum. Reports 2004. 6:156-163. PDF.

Graham, K.L., K.E. Gustin, C. Rivera, N.M. Kuyumcu-Martinez, S.S. Choe, R.E. Lloyd P. Sarnow and P.J. Utz, 2004. Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection. J. Virol . 78:6313-21. PDF.

Graham K.L., W.H. Robinson, L. Steinman and P.J. Utz, 2004. High-throughput methods for measuring autoantibodies in systemic lupus erythematosus and other autoimmune diseases. Autoimmunity . 37:269-72. Review. PDF

Hueber, W. and Utz, P.J. "Modifications of RNA During Apoptosis." In, Apoptosis and Autoimmunity, Edited by Joachim Kalden and Martin Herrmann. 2003. 299-315.

Hueber, W., D. Zeng, O. Sharpe, W.H. Robinson, S. Strober and P.J. Utz, 2004. Characterization of novel antigens recognized by serum autoantibodies from anti-CD1 TCR-transgenic lupus mice. Eur. J. Immunol. 34:1654–1662. PDF.

Hueber, W., D. Zeng, S. Strober and P.J. Utz, 2004. Interferon-alpha-inducaible proteins are novel antigens in murine lupus. Arthritis and Rheumitism. 50:3239-3249. PDF.

Su, L., R.J. Creusot, E.Gallo, S.M. Chan, P.J. Utz, C.G. Fathman and J. Ermann, 2004. Murine CD4+CD25+-regulatory T-cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene. J. Immuol . 173:4994-5001. PDF.

Utz P.J., 2004. Hot technologies in immunology. Clin. Immunol. 111:153-4. PDF.

Utz, P.J., 2004. Multiplexed assays for identification of biomarkers and surrogate markers in systemic lupus erythematosus. Lupus. 13:304-11. PDF.

Utz., P.J. and S. Chan, 2004. Autoantibodies profiling and lymphocyte characterization using autoantigen and lysate arrays. In Pathogenic and Diagnostic Relevance of Autoantibodies . K. Conrad, R. L. Humbel, M. Meurer, Y. Shoenfeld, E.M. Trans (Eds.) 7th Dresden, Sept. 1-4, 2004.

Utz P.J., M.C. Genovese and W.H. Robinson, 2004.Unlocking the "PAD" lock on rheumatoid arthritis. Ann. Rheum. Dis. 4:330-332. PDF.

Utz P.J., L. Steinman and W.H. Robinson, 2004. Protein microarrays for analysis of immune responses in animals and humans. In: Protein Micoarrays , pp 365-376, Edited by Michael Schena. Jones and Bartlett, Sudbury, MA.

2003

Chen, R.J., S. Bangsaruntip, K. A. Drouvalakis, N.W.S. Kam, M. Shim, Y. Li, W. Kim, P.J. Utz and H. Dai, 2003. Noncovalent functionalization of carbon nanotubes for highly specific electronic sensors. Proc. Natl. Acad. Sci. USA 100:4984-4989. PDF.

Herr, A.E., J.I. Molho, K.A. Drouvalakis, J.C. Mikkelsen, P.J. Utz, J.G. Santiago and T.W. Kenny, 2003. On-Chip Coupling of Isoelectric Focusing and Free Solution Electrophoresis for Multi-Dimensional Separations. Anal. Chem. 75:1180-1187. PDF.

Hueber, W. and .J. Utz, 2003. Modifications of RNA during apoptosis. In: Apoptosis and Autoimmunity , pps. 299-315. Edited by Joachim Kalden and Martin Herrmann.

Hueber W., P.J. Utz and W.H, Robinson, 2003. Autoantibodies in early arthritis: advances in diagnosis and prognostication. Clin Exp Rheumatol . 21(5 Suppl 21): S59-64. Review. PDF.

Neuman de Vegvar, H.E., R.R. Amara, L. Steinman, P.J. Utz, H.L. Robinson and W.H. Robinson, 2003. Microarray profiling of antibody responses against Simian-Human immunodeficiency virus: Postchallenge of host histocompatibility type and vaccine regimen. J. Virol.77:11125-11138. PDF.

Robinson, W.H., P. Fontoura, B.J. Lee, H.E. Neuman de Vegvar, J. Tom, R. Pedotti, C.D. DiGennaro, D.J. Mitchell, D. Fong, P.P-K. Ho, P. Ruiz, E. Maverakis, D.B. Stevens, C.C.A. bernard, R. Martin, V.K. Kuchroo, J.M. van Noort, C.P. Genain, S. Amor, T. Olsson, P.J. Utz*, H. Garren* and L. Steinman*, 2003. Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nature Biotechnol . 21:1033-1039. *All three authors contributed equally to this paper. PDF.

Robinson, W.H., L. Steinman, and P.J. Utz, 2003. Protein arrays for autoantibody profiling and fine-specificity mapping. Proteomics , 3:2077-84. PDF.

Robinson, W.H., P.J. Utz, and L. Steinman, 2003. Genomic and proteomic analysis of multiple sclerosis. Opinion. Curr Opin Immunol. 15:660-7. PDF.

Thibault, D.L and P.J. Utz, 2003. Interpreting interest in interferon-alpha. Arthritis Res. and Res. The r. 5(5):246-248. PDF.

2002

Hueber W., P.J. Utz, L. Steinman and W.H,Robinson, 2002. Autoantibody profiling for the study and treatment of autoimmune disease. Arthritis Res. 4(5):290-5. Review. PDF.

Kamachi M. T.M. Le, S. Kim, M.E. Geiger, P. Anderson and P.J. Utz, 2002. Human Autoimmune Sera: Molecular Probes for the Identification of a Novel Autoantigen Kinase Signalling Pathway. J. Exp. Med . 196:1213-1226. PDF.

Robinson W.H., H. Garren, P.J. Utz and L. Steinman, 2002. Millennium Award. Proteomics for the development of DNA tolerizing vaccines to treat autoimmune disease. Clin Immunol. 103(1):7-12. Review. PDF.

Robinson W.H., L. Steinman and P.J. Utz, 2002. Protein and peptide array analysis of autoimmune disease. Biotechniques. Suppl:66-9. Review. PDF.

2001

Gensler T., M. Hottelet, C. Zhang, S. Schlossman, P. Anderson and P.J. Utz, 2001. Monoclonal antibodies derived from Balb/c mice immunized with apoptotic Jurkat T cells recognize known autoantigens. J. Autoimm . 16:59-69. PDF.

Utz, P.J., 2001. Report of the XXX EWRR, Vienna, Austria, March 2001. Arthritis Research .3:237-240. PDF.

2000

Degen, W.G.J., Y. van Aarssen, P. Piepers, G.J.M. Pruijn, P.J. Utz and W.J. van Venrooij, 2000. The fate of the U1 small nuclear RNP complex during anti-Fas induced apoptosis: specific cleavage of the U1 snRNA molecule. Cell Death and Differentiation . 7:70-80. PDF.

Overzet K., T.J. Gensler, M.E. Geiger, S.J. Kim, M. Hottelet, W.J. van Venrooij, K.M. Pollard, P. Anderson and P.J. Utz, 2000. Small nucleolar ribonucleoprotein (snoRNP) scleroderma autoantigens associate with phosphorylated serine arginine (SR) splicing factors during apoptosis.Arth. Rheum . 43:1327-1336. PDF.

Utz, P.J. and P. Anderson, 2000. Review: Life and Death Decisions: Regulation of Apoptosis by Proteolysis of Signaling Molecules. Cell Death and Differentiation . 7:589-602. PDF.

Utz P.J., T.J. Gensler and P. Anderson, 2000. Review: Death, autoantigen modifications, and tolerance. Arth. Res . 2:101-114. PDF.

1999

Rutjes S.A., A. van der Heijden, P.J. Utz, W.J. van Venrooij and G.J Pruijn, 1999. Rapid nucleolytic degradation of the small cytoplasmic Y RNAs during apoptosis. Journal of Biological Chemistry . 1999. 274(35):24799-807. PDF

Rutjes, S.A., P.J. Utz, C. Broekhuis, A. van der Heijden, W.J. van Venrooij, and G.J.M. Pruijn, 1999. The La (SS-B) autoantigen, a key protein in RNA biogenesis, is dephosphorylated and cleaved early during apoptosis. Cell Death and Differentiation . 6:976-986. PDF

1998

Utz. P.J. and P. Anderson, 1998. Review: Posttranslational Protein Modifications, Apoptosis, and the Bypass of Tolerance to Autoantigens. Arthritis and Rheumatism . 41:1152-1160. PDF.

Utz. P.J., M. Hottelet, S. Kim, M. Geiger, T. Le, W.J. vanVenrooij and P. Anderson, 1998. The 72 kDa component of signal recognition particle (SRP) is cleaved during apoptosis. Journal of Biological Chemistry . 273:35299-35361. PDF.

Utz. P.J., M. Hottelet, W.J. van Venrooij and P. Anderson, 1998. Association of phosphorylated serine/arginine (SR) splicing factors with the U1-snRNP autoantigen complex accompanies apoptotic cell death. Journal of Experimental Medicine . 187:547-560. PDF.

1997

Utz. P.J., M. Hottelet, P.H. Schur and P. Anderson, 1997. Proteins phosphorylated during stress-induced apoptosis are common targets for autoantibody production in patients with systemic lupus erythematosus. Journal of Experimental Medicine . 185:843-854. PDF.

1991

Varon, J., J.R. Hamilton, J. Hostetler, P.J. Utz and A. Ganer, 1991. Meningitis due to Group C streptococci. Hospital Physician . December 31-33.

1989

Naumovski, L., P.J. Utz, S.K. Bergstrom, R. Morgan, A. Molina, J.J. Toole, B.E. Glader, P. McFall, L.M. Weiss, R. Warnke, and S.D. Smith, 1989. SUP-HD1: A new Hodgkin's Disease-derived cell line with lymphoid features produces interferon gamma. Blood . 74(8): 2733-2742. PDF.

1988

Shaw, J.P., P.J. Utz, D.B. Durand, J.J. Toole, E.A. Emmel, and G.R. Crabtree. Identification of a putative regulator of early T-cell activation genes. Science . 1988. 241:202-205. PDF.

Sylvester, P.W., P.J. Utz, and M.M. Ip, 1988. . Effects of the thiazolidinedione derivative CGP 19984 on growth and endocrine function of the MtTW10 transplantable mammosomatotropic pituitary tumor in the female rat. International Journal of Cancer . 1988. 42:289-294. PDF.