Our laboratory has been focusing on liver fibrogenesis, elucidating the links between activation of redox pathways, hepatocyte cell death, stellate cell activation and transdifferentiation to myofibroblasts. We have been interested in the role of NADPH oxidases and their cell-specific roles in liver injury and repair.   We are also investigating the role of extracellular matrix in guiding wound healing and focusing on how cells perceive changes in their environment. Non-alcoholic steatohepatitis (NASH) is becoming the most common liver disease in the US and worldwide and our ultimate goal is to translate our findings and develop novel therapeutic approaches that reverse fibrosis in NASH and improve patient outcomes.