THE STUART B. GOODMAN LAB
DEPARTMENT OF ORTHOPAEDIC SURGERY
Our research seeks to understand the mechanisms of various musculoskeletal conditions related to fractures and bone defects, total joint replacement, arthritis, and osteonecrosis etc. based on the cross-talk between cells in the mesenchymal and the hematopoietic lineages.
In particular, the key role that macrophages play in the recruitment and differentiation of mesenchymal stem cells (MSCs) during bone regeneration has been brought to focus. Currently, we concentrate on the following areas:
1. the biological aspects of the interface between orthopaedic implants/biomaterials and bone,
2. the innate immune system and macrophages,
3. tissue engineering and mesenchymal tissue differentiation,
4. total joint replacement: prosthesis design, biomechanics, biomaterials, mechanisms of failure, imaging etc.,
5. arthritis: etiology, diagnosis, imaging, treatment, outcomes,
6. and osteonecrosis.
Our research is highly interdisciplinary. We work at the interface of immunology, biomaterials, bioengineering and medicine. Please visit our Research and Publications pages to learn more.
Recent Publications
