We focus on the rare disease, Moyamoya disease (MMD). MMD has known etiology and can lead to hemorrhage and/or seizures. We use biochemical, genetic and biological approaches to advance our understanding of why this disease occurs and what the mechanisms of action are, with the ultimate goal of developing therapies that improve diagnosis and treatment.
This disease is challenging to study, however, as no in vivo or in vitro disease models exist. Our highly translational research is based entirely on human samples and facilitated by our close relationship Stanford MMD patients.
Our group has benefited greatly from the talented undergraduate researchers who have worked with us on these two rare diseases.