Publications

MRI of [2‐13C] Lactate without J-coupling artifacts. Datta K, Spielman D. Magn Reson Med. 2020 Oct 15. doi: 10.1002/mrm.28532. Epub ahead of print. PMID: 33058240.

Thalamic and prefrontal GABA concentrations but not GABA receptor densities are altered in high-functioning adults with autism spectrum disorder. Fung LK, Flores RE, Gu M, Sun KL, James D, Schuck RK, Jo B, Park JH, Lee BC, Jung JH, Kim SE, Saggar M, Sacchet MD, Warnock G, Khalighi MM, Spielman D, Chin FT, Hardan AY. Mol Psychiatry. 2020 May 6. doi: 10.1038/s41380-020-0756-y. Epub ahead of print. PMID: 32376999.

Reversed metabolic reprogramming as a measure of cancer treatment efficacy in rat C6 glioma model. Datta K, Lauritzen MH, Merchant M, Jang T, Liu SC, Hurd R, Recht L, Spielman DM. PLoS One. 2019 Dec 12;14(12):e0225313. doi: 10.1371/journal.pone.0225313. PMID: 31830049; PMCID: PMC6907781.

Comparison of dynamic brain metabolism during antegrade cerebral perfusion versus deep hypothermic circulatory arrest using proton magnetic resonance spectroscopy. Hanley FL, Ito H, Gu M, Hurd R, Riemer RK, Spielman D. J Thorac Cardiovasc Surg. 2020 Oct;160(4):e225-e227. doi: 10.1016/j.jtcvs.2019.10.103. Epub 2019 Nov 5. PMID: 31780069.

Effects of acute N-acetylcysteine challenge on cortical glutathione and glutamate in schizophrenia: A pilot in vivo proton magnetic resonance spectroscopy study. Girgis RR, Baker S, Mao X, Gil R, Javitt DC, Kantrowitz JT, Gu M, Spielman DM, Ojeil N, Xu X, Abi-Dargham A, Shungu DC, Kegeles LS. Psychiatry Res. 2019 May;275:78-85. doi: 10.1016/j.psychres.2019.03.018. Epub 2019 Mar 12. PMID: 30884334; PMCID: PMC6515541.

Multimodality Hyperpolarized C-13 MRS/PET/Multiparametric MR Imaging for Detection and Image- Guided Biopsy of Prostate Cancer: First Experience in a Canine Prostate Cancer Model. Bachawal SV, Park JM, Valluru KS, Loft MD, Felt SA, Vilches-Moure JG, Saenz YF, Daniel B, Iagaru A, Sonn G, Cheng Z, Spielman DM, Willmann JK. Mol Imaging Biol. 2019 Oct;21(5):861-870. doi: 10.1007/s11307-018-1235-6. PMID: 30793241.

Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology. Kurhanewicz J, Vigneron DB, Ardenkjaer-Larsen JH, Bankson JA, Brindle K, Cunningham CH, Gallagher FA, Keshari KR, Kjaer A, Laustsen C, Mankoff DA, Merritt ME, Nelson SJ, Pauly JM, Lee P, Ronen S, Tyler DJ, Rajan SS, Spielman DM, Wald L, Zhang X, Malloy CR, Rizi R. Neoplasia. 2019 Jan;21(1):1-16. doi: 10.1016/j.neo.2018.09.006. Epub 2018 Nov 23. PMID: 30472500; PMCID: PMC6260457.

PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose. Tee SS, Park JM, Hurd RE, Brimacombe KR, Boxer MB, Massoud TF, Rutt BK, Spielman DM. Oncotarget. 2017 Jul 26;8(53):90959-90968. doi: 10.18632/oncotarget.19630. PMID: 29207616; PMCID: PMC5710897.

A proton MR spectroscopy study of the thalamus in twins with autism spectrum disorder. Hegarty JP 2nd, Gu M, Spielman DM, Cleveland SC, Hallmayer JF, Lazzeroni LC, Raman MM, Frazier TW, Phillips JM, Reiss AL, Hardan AY. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 2;81:153-160. doi: 10.1016/j.pnpbp.2017.09.016. Epub 2017 Sep 21. PMID: 28941767; PMCID: PMC5731458.

Hyperpolarized Sodium 1-13C-Glycerate as a Probe for Assessing Glycolysis In Vivo. Park JM, Wu M, Datta K, Liu SC, Castillo A, Lough H, Spielman DM, Billingsley KL. J Am Chem Soc. 2017 May 17;139(19):6629-6634. doi: 10.1021/jacs.7b00708. Epub 2017 May 8. PMID: 28467066; PMCID: PMC5519508.

Real-Time in Vivo Detection of H2O2 Using Hyperpolarized 13C-Thiourea. Wibowo A, Park JM, Liu SC, Khosla C, Spielman DM. ACS Chem Biol. 2017 Jul 21;12(7):1737-1742. doi: 10.1021/acschembio.7b00130. Epub 2017 Jun 5. PMID: 28452454; PMCID: PMC5584590.

GABA editing with macromolecule suppression using an improved MEGA-SPECIAL sequence. Gu M, Hurd R, Noeske R, Baltusis L, Hancock R, Sacchet MD, Gotlib IH, Chin FT, Spielman DM. Magn Reson Med. 2018 Jan;79(1):41-47. doi: 10.1002/mrm.26691. Epub 2017 Mar 31. PMID: 28370458; PMCID: PMC5623603.

In vivo assessment of intracellular redox state in rat liver using hyperpolarized [1-13C]Alanine. Park JM, Khemtong C, Liu SC, Hurd RE, Spielman DM. Magn Reson Med. 2017 May;77(5):1741-1748. doi: 10.1002/mrm.26662. Epub 2017 Mar 5. PMID: 28261868; PMCID: PMC5523144.

Doublet asymmetry for estimating polarization in hyperpolarized 13C-pyruvate studies. Datta K, Spielman DM. NMR Biomed. 2017 Feb;30(2): 10.1002/nbm.3670. doi: 10.1002/nbm.3670. Epub 2016 Dec 22. PMID: 28004867; PMCID: PMC5330392.

Hyperpolarized (13)C-lactate to (13)C-bicarbonate ratio as a biomarker for monitoring the acute response of anti-vascular endothelial growth factor (anti- VEGF) treatment. Park JM, Spielman DM, Josan S, Jang T, Merchant M, Hurd RE, Mayer D, Recht LD. NMR Biomed. 2016 May;29(5):650-9. doi: 10.1002/nbm.3509. Epub 2016 Mar 14. PMID: 26990457; PMCID: PMC4833516.

Metabolite-selective hyperpolarized (13)C imaging using extended chemical shift displacement at 9.4T. Yang S, Lee J, Joe E, Lee H, Choi YS, Park JM, Spielman D, Song HT, Kim DH. Magn Reson Imaging. 2016 May;34(4):535-40. doi: 10.1016/j.mri.2015.12.023. Epub 2015 Dec 18. PMID: 26707851; PMCID: PMC4801652.

Volumetric spiral chemical shift imaging of hyperpolarized [2-(13) c]pyruvate in a rat c6 glioma model. Park JM, Josan S, Jang T, Merchant M, Watkins R, Hurd RE, Recht LD, Mayer D, Spielman DM. Magn Reson Med. 2016 Mar;75(3):973-84. doi: 10.1002/mrm.25766. Epub 2015 May 6. PMID: 25946547; PMCID: PMC4636489.

Assessing inflammatory liver injury in an acute CCl4 model using dynamic 3D metabolic imaging of hyperpolarized [1-13C]pyruvate. Josan S, Billingsley K, Orduna J, Park JM, Luong R, Yu L, Hurd R, Pfefferbaum A, Spielman D, Mayer D.NMR Biomed. 2015 Dec;28(12):1671-7. doi: 10.1002/nbm.3431. Epub 2015 Oct 16. PubMed PMID: 26474216;

Hyperpolarized 13C NMR observation of lactate kinetics in skeletal muscle. Park JM, Josan S, Mayer D, Hurd RE, Chung Y, Bendahan D, Spielman DM, Jue T.J Exp Biol. 2015 Oct;218(Pt 20):3308-18. doi: 10.1242/jeb.123141. Epub 2015 Sep 7. PubMed PMID: 26347554.

Volumetric spiral chemical shift imaging of hyperpolarized [2-13C]pyruvate in a rat c6 glioma model. Park JM, Josan S, Jang T, Merchant M, Watkins R, Hurd RE, Recht LD, Mayer D, Spielman DM. Magn Reson Med. 2015 May 6. doi: 10.1002/mrm.25766. [Epub ahead of print] PMID: 25946547

Multivendor implementation and comparison of volumetric whole-brain echo-planar MR spectroscopic imaging. Sabati M, Sheriff S, Gu M, Wei J, Zhu H, Barker PB, Spielman DM, Alger JR, Maudsley AA. Magn Reson Med. 2014 Oct 29. doi: 10.1002/mrm.25510. [Epub ahead of print] PMID: 25354190

The feasibility of assessing branched-chain amino acid metabolism in cellular models of prostate cancer with hyperpolarized [1-(13)C]-ketoisocaproate. Billingsley KL, Park JM, Josan S, Hurd R, Mayer D, Spielman-Sun E, Nishimura DG, Brooks JD,Spielman D. Magn Reson Imaging. 2014 Sep;32(7):791-5. doi: 10.1016/j.mri.2014.04.015. Epub 2014 Apr 28. PMID: 24907854

Hyperpolarized [1,4-(13)C]-diethylsuccinate: a potential DNP substrate for in vivo metabolic imaging. Billingsley KL, Josan S, Park JM, Tee SS, Spielman-Sun E, Hurd R, Mayer D, Spielman D. NMR Biomed. 2014 Mar;27(3):356-62. doi: 10.1002/nbm.3071. Epub 2014 Jan 13. PMID: 24421249

Volumetric spiral chemical shift imaging of hyperpolarized [2-13C]pyruvate in a rat C6 glioma model. Park JM, Josan S, Jang T, Merchant M, Watkins R, Hurd RE, Recht LD, Mayer D, Spielman DM. Magn Reson Med. 2015 May 6. doi: 10.1002/mrm.25766. [Epub ahead of print] PMID: 25946547

Hyperpolarized [1,4-(13)C]-diethylsuccinate: a potential DNP substrate for in vivo metabolic imaging. Billingsley KL, Josan S, Park JM, Tee SS, Spielman-Sun E, Hurd R, Mayer D,Spielman D. NMR Biomed. 2014 Mar;27(3):356-62. doi: 10.1002/nbm.3071. Epub 2014 Jan 13. PMID: 24421249

Measuring mitochondrial metabolism in rat brain in vivo using MR Spectroscopy of hyperpolarized [2-¹³C]pyruvate. Park JM, Josan S, Grafendorfer T, Yen YF, Hurd RE, Spielman DM, Mayer D. NMR Biomed. 2013 Oct;26(10):1197-203. doi: 10.1002/nbm.2935. Epub 2013 Apr 2. PMID: 23553852

Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging. Park JM, Recht LD, Josan S, Merchant M, Jang T, Yen YF, Hurd RE, Spielman DM, Mayer D. Neuro Oncol. 2013 Apr;15(4):433-41. doi: 10.1093/neuonc/nos319. Epub 2013 Jan 17. PMID: 23328814

Quantification of glutamate and glutamine using constant-time point-resolved spectroscopy at 3 T. Gu M, Zahr NM, Spielman DM, Sullivan EV, Pfefferbaum A, Mayer D. NMR Biomed. 2013 Feb;26(2):164-72. doi: 10.1002/nbm.2831. Epub 2012 Jul 4. PMID: 22761057

In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate. Josan S, Xu T, Yen YF, Hurd R, Ferreira J, Chen CH, Mochly-Rosen D, Pfefferbaum A, Mayer D, Spielman D. NMR Biomed. 2013 Jun;26(6):607-12. doi: 10.1002/nbm.2897. Epub 2012 Dec 6. PMID: 23225495

In vivo MRSI of hyperpolarized [1-(13)C]pyruvate metabolism in rat hepatocellular carcinoma. Darpolor MM, Yen YF, Chua MS, Xing L, Clarke-Katzenberg RH, Shi W, Mayer D, Josan S, Hurd RE, Pfefferbaum A, Senadheera L, So S, Hofmann LV, Glazer GM, Spielman DM. NMR Biomed. 2011 Jun;24(5):506-13. doi: 10.1002/nbm.1616. Epub 2010 Dec 12. PMID: 21674652

Designing adiabatic radio frequency pulses using the Shinnar-Le Roux algorithm. Balchandani P, Pauly J, Spielman D. Magn Reson Med. 2010 Sep;64(3):843-51. doi: 10.1002/mrm.22473. PMID: 20806378

Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate. Hurd RE, Yen YF, Mayer D, Chen A, Wilson D, Kohler S, Bok R, Vigneron D, Kurhanewicz J, Tropp J, Spielman D, Pfefferbaum A. Magn Reson Med. 2010 May;63(5):1137-43. doi: 10.1002/mrm.22364. PMID: 20432284

In vivo application of sub-second spiral chemical shift imaging (CSI) to hyperpolarized 13C metabolic imaging: comparison with phase-encoded CSI. Mayer D, Yen YF, Levin YS, Tropp J, Pfefferbaum A, Hurd RE, Spielman DM. J Magn Reson. 2010 Jun;204(2):340-5. doi: 10.1016/j.jmr.2010.03.005. Epub 2010 Mar 9. PMID: 20346717

Parallel spectroscopic imaging reconstruction with arbitrary trajectories using k-space sparse matrices. Gu M, Liu C, Spielman DM. Magn Reson Med. 2009 Feb;61(2):267-72. doi: 10.1002/mrm.21838. PMID: 19165883

Slice-selective tunable-flip adiabatic low peak-power excitation pulse. Balchandani P, Pauly J, Spielman D. Magn Reson Med. 2008 May;59(5):1072-8. doi: 10.1002/mrm.21540. PMID: 18429017

Fast CT-PRESS-based spiral chemical shift imaging at 3 Tesla. Mayer D, Kim DH, Adalsteinsson E, Spielman DM. Magn Reson Med. 2006 May;55(5):974-8. PMID: 16586451

Regularized higher-order in vivo shimming. Kim DH, Adalsteinsson E, Glover GH, Spielman DM. Magn Reson Med. 2002 Oct;48(4):715-22. PMID: 12353290

Volumetric spectroscopic imaging with spiral-based k-space trajectories. Adalsteinsson E, Irarrazabal P, Topp S, Meyer C, Macovski A, Spielman DM. Magn Reson Med. 1998 Jun;39(6):889-98. PMID: 9621912

Estimating NAA in cortical gray matter with applications for measuring changes due to aging. Lim KO, Spielman DM. Magn Reson Med. 1997 Mar;37(3):372-7. PMID: 9055227

Magnetic resonance fluoroscopy using spirals with variable sampling densities. Spielman DM, Pauly JM, Meyer CH. Magn Reson Med. 1995 Sep;34(3):388-94. PMID: 7500878