Cissarek et al: Gefaessmedizin: Therapie und Praxis. Spiekerkoetter Edda Kapitel: Die akute Lungenembolie und pulmonale arterielle Hypertonie. ABW Wissenschaftsverlag, Berlin 2009.
Cissarek et al: Vascular Medicine: Therapy And Practice. Spiekerkoetter Edda: Chapter: Acute pulmonary embolism and pulmonary Arterial Hypertension. Mcgraw-hill Professional Publishing 2010.
Edda Spiekerkoetter and Marlene Rabinovitch. Genomics in Pulmonary Arterial Hypertension. Braunwald’s Heart Disease 9th edition, electronic version 2013.
R01 HL158868 (PI Spiekerkoetter)
NIH/NHLBI
07/2021-05/2025
Understanding and targeting molecular as well as structural events governing right ventricular adaptation, failure and recovery in pulmonary hypertension using repurposed drugs
R01 HL169787 (PI Spiekerkoetter)
NIH/NHLBI
9/2023-08/2027
Understanding and targeting molecular and cellular events responsible for pulmonary arteriovenous malformation development, growth and regression
R01 HL152250 (PI Kheyfets, Co-Investigator Spiekerkoetter)
NIH/NHLBI
02/2023-12/2026
What triggers RV Fiber Re-Orientation in response to RV pressure overload, and what is its Consequence on Inter-Ventricular Decoupling?
R01HL163013 (PI Kumar, Co-Investigator Spiekerkoetter)
NIH/NHLBI
03/2022-02/2026
Defining the cellular and molecular mechanisms driving neointimal lesion growth in pulmonary hypertension
R01 HL165245 (PI Reddy, Co-Investigator Spiekerkoetter)
NIH/NHLBI
07/2023-06/2028
Lipid Peroxidation-Induced Mitochondrial Injury Inhibits Vascular Function in Single Ventricle Congenital Heart Disease
K08 Career development award 1K08HL107450-01
09/01/2011 - 07/31/2016
National Institutes of Health Modulating BMPRII Signaling in Pulmonary Arterial Hypertension The goals of this project are to use new technologies to modulate BMP signaling using High Throughput Screening of FDA approved drugs and bioactive compounds as well as microRNA mimics and antagomirs.
Mentors: Marlene Rabinovitch, Phil Beachy
Role on Project: PI
2011 Pulmonary Hypertension Association (PHA) supplemental grant for awarded K08 in PAH In conjunction with 1K08HL107450-0-NIH
09/01/2011 - 08/31/2016 Modulating: BMPRII Signaling in Pulmonary Arterial Hypertension
Role on Project: PI
Wall Center Faculty Research Scholar Award: 1144545-101-GHDCK Vera Moulton Wall Center for Pulmonary Vascular Disease
06/01/2012 - 05/30/2017 Developing novel therapies for pulmonary arterial hypertension by targeting the BMP pathway
Role on Project: PI
Helmholtz International Research Group
5/1/2013 – 4/30/2016 Increasing BMP signaling in neonatal chronic lung disease Joint project with Anne Hilgendorff, Helmholtz Zentrum Munich, Germany with the goal to establish a collaboration amongst young investigators as well as to develop an exchange program for postdoctoral research fellows from both institutions.
Role on Project: Co-PI
Bernstein, Daniel – Project 117996
07/01/2016–06/30/2019
Department of Defense Non-cardiomyocyte MicroRNAs Mediate Susceptibility to Right Heart Failure
Major goals: To determine whether RV-specific miRs 34a and 148a, through direct effects in endothelial cells and through crosstalk with cardiomyocytes, are responsible for the attenuated angiogenic response in RV failure.
Role on Project: Co-Investigator
1 R01 HL128734-01A1
04/01/2016-03/31/2021
National Institutes of Health Targeting Novel BMPR2 modifiers in Pulmonary Hypertension with Repurposed Drugs Major goals: To identify modifier genes of BMPR2 that could be targeted with repurposed drugs to increased BMPR2 signaling and improve pulmonary hypertension, using siRNA high throughout screening as well as publicly available gene expression data bases of samples from pulmonary hypertension patients.
Role on the Project: PI
VPUE Faculty Grants for Undergraduate Research 10/1/2014 – 09/30/2015
Stanford University
Spark Research Grant SPARK Scholar (For Translational Research)
03/1/2014– 04/30/2015 Phase II trial of Tacrolimus in Pulmonary Hypertension
The goal of this project is to perform a phase II tolerability and efficacy study with Tacrolimus in patients with pulmonary arterial hypertension with dysfunctional BMPRII signaling.
Role on Project: Co-PI
Spectrum Pilot Grant, Stanford University NIH CTSA award UL1 RR025744
02/01/2012 – 01/31/2013 Phase II trial of Tacrolimus in Pulmonary Hypertension
The goal of this project is to perform a phase II tolerability and efficacy study with Tacrolimus in patients with pulmonary arterial hypertension with dysfunctional BMPRII signaling. Our previous research has shown that low dose Tacrolimus can prevent and reverse experimental pulmonary hypertension in mice and rats by restoring BMPR2 signaling and improving endothelial dysfunction.
PI: Harry Greenberg
Role on Project: Co-PI
Wall Center Seed Grant 1/11/2011 – 31/10/2014
Vera Moulton Wall Center for Pulmonary Vascular Disease Phase II trial of Tacrolimus in Pulmonary Hypertension
The goal of this project is to perform a phase II tolerability and efficacy study with Tacrolimus in patients with pulmonary arterial hypertension with dysfunctional BMPRII signaling.
Role on Project: Co-PI
Wall Center Seed Grant: 1149670 -111-GHDGQ 09/01/2011- 12/31/2013
Vera Moulton Wall Center for Pulmonary Vascular Disease Small Molecule Screen for compounds that activate BMPRII signaling
The goal of this project is to use High Throughput Screening to find new small molecules that could potentially increase or inhibit BMP signaling.
Role on Project: PI
Cardiovascular Institute Seed Grant 01/01/2013 – 012/31/2013 Increasing BMP signaling to improve right ventricular function in congenital heart disease
Role on Project: PI
Collaborators: Dres Bernstein and Reddy, Pediatric Cardiology, Stanford
K12 Career Development Award, Genetics and Genomics of Pulmonary Diseases 09/2009 – 08/2011
Director Prof. M Krasnow, Co-director Prof. M Rabinovitch
Development of High-Throughput Screen of drugs that modulates bone morphogenetic protein receptor II Role on Project: Trainee
AHA 0325750H 7/1/2003 – 6/30/2005
Pulmonary Hypertension Association (PHA) and American Heart Association (AHA) Postdoctoral Research Fellowship Award Stromal Derived factor modulates homing and differentiation of stem cells in pulmonary hypertension
The goals of the project were to identify the role of the chemokine stromal derived factor-1 (SDF-1) and its receptor CXCR4 in pulmonary hypertension (PH).
Role on Project: PI
