Current Projects

Screenomics

Digital experiences capture an increasingly large part of life, making them a preferred, if not required, method to describe and theorize about human behavior. Digital media also shape behavior by enabling people to switch between different content easily, and create unique threads of experiences that pass through numerous information categories.  The Stanford Screenomics Lab is building a framework to study moment-by-moment changes in how people use digital media by recording screen shots from personal digital devices every five seconds.  We are currently recruiting adolescents and their parents for  The Family Smartphone Study, a national study on smartphone use and health.

WISE

Wise Social Psychological Interventions to Improve Outcomes of Behavioral Weight Control in Children with Obesity (funded by NIH RO1 DK123286)

The modest, transient and highly variable outcomes from many behavioral treatments for pediatric obesity may be, in part, because of the psychological barriers children with obesity face when trying to control their weight. This randomized controlled trial in 8-12 year old children with obesity tests our hypothesis that adding two innovative, brief, social psychological interventions (termed “wise” interventions, growth mindset and self-affirmation) to a behavioral weight control program, will produce better results than the behavioral program alone.  This approach has the potential to substantially reduce the variability and improve outcomes of pediatric weight control treatments and significantly reduce concurrent and future health, psychological and social harms from childhood obesity.

Stanford CORD 3.0 (funded by CDC U18 DP006423)

Packaging and Spreading the Stanford Pediatric Weight Control Program - A Family-Based, Group, Behavioral Weight Control Program for Children with Obesity and their Families

Efficacious treatments for children exist but are not widely available. We are utilizing technology, design, behavioral theory and biomedical business innovation strategies to package and spread the Stanford Pediatric Weight Control Program to reach low-income children throughout the U.S. To accomplish this aim, we are guided by an approach that merges design thinking, behavioral science, and business development strategy.

iPOP: SPHERE Project 2

Integrative Personalized Omics Profiling (iPOP) in Overweight and Obese Latinx Children (funded by NIH U54 MD010724, Project 2

Our long-term goal is to reduce health disparities by developing and applying omics technologies (genomics, transcriptomics, epigenomics, metabolomics, microbiomics) to more effectively prevent and treat excess weight gain and diabetes risk. The first step toward this goal, is to quantify metabolic and biomolecular differences that are associated with and/or predict obesity and diabetes risk, and to characterize the heterogeneous biological responses and moderators and mediators to interventions to reduce weight gain, among Latinx children participating in a randomized trial. The results of this study will enable discovery of new associations, predictions, and precision interventions not previously possible and will potentially inform future studies among Latinx and other minority populations.

Telomeres

Telomere Length Changes as a Marker of Chronic Disease Risk Among Children Participating in Lifestyle Behavior Change (funded by NIH, NCATS, Stanford CTSA to SPECTRUM UL1 TR001085)

To (1) examine variability in leukocyte telomere length within children over time and (2) test whether telomere length and changes in telomere length over time are associated with behavioral and physiological cardiovascular disease and diabetes risk factors and their changes among a 18-month cohort of 192 well-phenotyped, racially/ethnically-diverse obese 8-12-year-old children who participated in a family-based behavioral weight control program including nutrition, physical activity and screen time reduction.

 

CHEAR

Perfluoroalkly and Polyfluoroalkyl Substances, protein biomarkers, and adiposity in a 3-year Cohort of Low-Income Latino Children with Overweight and Obesity from the Stanford GOALS Trial (funded by NIH, Children’s Health Exposure Analysis Resource – CHEAR, Project 2017-1967)

This study investigates the cross-sectional and longitudinal relationships between plasma perfluoroalkyl and polyfluoroalkyl substances (PFAS), protein biomarkers and adiposity and cardiometabolic risk factors for cardiovascular disease and type 2 diabetes mellitus among low-income primarily Latinx children from the Stanford GOALS trial.


Gardner GOALS

Gardner GOALS is a home- and family-based weight control program that draws on our experience working in the homes of hundreds of families in the Stanford GOALS community-based research trial, insights and recommendations from Gardner Packard pediatricians delivering community-based primary care, and a small feasibility trial recently completed at Gardner Packard Children's Health.