Singh Lab

Our lab studies the molecular basis of pathogenesis of two medically important parasites, Toxoplasma gondii and Entamoeba histolytica. The work is aimed at understanding the virulence determinant that each parasite uses in causing disease, specifically how T. gondii evades the human immune response by converting to a dormant bradyzoite stage and how E. histolytica causes invasive colonic and hepatic disease. In the recent past our efforts have been split evenly in studying both parasites, but we are now switching exclusively to the investigation of Entamoeba biology.

The work on E. histolytica is focused at identifying unique virulence mechanisms that the parasite has developed for causing invasive disease using a combination of genetic and genomics based approaches.