Current Lab News (2025)
Super fun sashimi and sake lab party celebrating successful summer and of course our new RO1ššš¾š„š„³šš!!
— Gen Shinozaki, MD (@GenShinozakiMD) August 31, 2024
I thank my lab members and collaborators for their strong work!šŖš» pic.twitter.com/hqN4O7ClCo
Three papers out from our lab!š„³š„³š„³
— Gen Shinozaki, MD (@GenShinozakiMD) July 28, 2024
(I should do summary posts on those, but sometime later when I am done with weekend clinical work...š)https://t.co/vGNCfc0jmNhttps://t.co/EnEbekmK6Yhttps://t.co/qW8uVqrykJ
Our new paper out!
— Gen Shinozaki, MD (@GenShinozakiMD) June 16, 2024
We tested our BSEEG method to assess recovery process after head mount surgery comparing young and aged mice.
Clear differences based on age and consistent with post operative delirium in human. Please check it out!https://t.co/spp0dsibnN
November 19th-22nd, 2025- PI, GenĀ ShinozakiĀ MD, delivered a keynote presentation and served as a mentor for young CL physician-scientist at the ACLP 2025 Developing Scholarship and Research Colloquium in San Antonio, TX.
- He also presented our new data as an oral presentation, titled āāDirect Evidence of Human Microglial Function in Delirium Pathophysiology.July 18, 2025
November 16th, 2025
New preprint out! We investigated the impact of pain for vulnerability to #delirium using #BSEEG mouse model.
Linking Pain and Delirium via Microglial Activation: A Mouse Study Using BSEEG, Behavioral Assays, Immunohistochemistry, and RNA Sequencing
November 13th, 2025Ā
New paper out! We reported the establishment of new organization called Japanese Delirium Society (JDS)! Inspired by colleagues across the globe, including ADS, ADA and EDA, we will work together to help patients with delirium through clinical practice, education and research!
Establishment and Future Prospects of the Japanese Delirium Society
October 21st, 2025
Exciting new paper out! We summarize the history and recent advancement ofĀ #EEGĀ technology for detection ofĀ #delirium. BSEEG can not only detect delirium but also predict patient mortality!
Bedside EEG for rapid diagnosis of delirium
- CONGRATULATIONS to everyone in the Shinozaki Lab! We are so proud to announce that the following papers have been published in Summer 2025! View the papers below:Ā
- Associations of metformin use history with delirium and mortality in patients with type 2 diabetes mellitus: A retrospective cohort study.
- Seki T, Yamanashi T, Shimura A, Chang G, Santiago TA, Phuong NJ, Nguyen HD, Gorantla N, Nishiguchi T, Yamanishi K, Ishii T, Aoyama B, Inoue T,Ā Shinozaki G.
The age-related susceptibility to postoperative delirium quantified by bispectral electroencephalography correlates with postoperative delirium-like behavior in mice.- Nishiguchi T, Yamanishi K, Shimura A, Seki T, Ishii T, Aoyama B, Gorantla N, Nguyen HD, Phuong NJ, Yamanashi T, Iwata M,Ā Shinozaki G.
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July 10, 2025
Congratulations to Nipun Gorantla, who was accepted into the Icahn School of Medicine at Mt. Sinai through their highly competitive FlexMed Early Assurance Program!
July 4, 2025
Dr. Shinozaki delivered a high-impact presentation, āGame changing approach for delirium: prediction of patient outcomes with novel bispectral EEG device and epigenetics mechanism of pathophysiology,ā at the Department of Psychiatry, Nagasaki University, Nagasaki, Japan ā demonstrating the labās leadership on the global stage.
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Shinozaki Lab at the American Delirium Society!
The Shinozaki Lab made a major multi-presentation impact at the Annual Meeting of the American Delirium Society in Nashville, TN:
Dr. Shinozaki presented āEstablishment of Japanese Delirium Society.ā
- Dr. Shinozaki presented two pivotal talks: āPostoperative Cognitive Dysfunction and Outcomes: Clinical Characteristics, Biomarkers, and Pathophysiology Following Cardiac and Non-Cardiac Surgeryā and āFrom Genes to Symptoms: Exploring Genetic and Epigenetic Pathways in Delirium.ā These sessions showcased groundbreaking links between clinical outcomes and molecular mechanisms.
Dr. ShinozakiĀ presented āEEG Signatures of Delirium: Bridging Insights from Bench to Bedsideā at theĀ Annual Meeting of the American Delirium Society, emphasizing the translational reach of the labās EEG technology.Dr. Aoyama and Dr. Shinozaki presented āExploring the Preventive Effects of Treadmill Exercise on Infection-Induced Delirium in Young Mice.ā
Dr. Ishii and Dr. Shinozaki presented āEpigenetic and Molecular Analysis of Resected Brain with Neurosurgery Patients Provide New Insights into Post-operative Delirium Pathogenesis.ā
Dr. Yamanishi and Dr. Shinozaki presented āThe Epigenetic Investigation of Human Induced Microglia-like (iMG) Cells Derived from Patients with Post-operative Delirium after Liver Transplant Surgery,ā earning the Best Basic Science Abstract Award ā a major accolade for the labās basic science contributions.5
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June 19ā21, 2025
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Dr. ShinozakiĀ served as a symposium panelist forĀ āUpdate on the delirium pathophysiological mechanismāĀ at the Japanese Society of Psychiatry and Neurologyās 121st Annual Convention in Kobe, Japan ā reinforcing international collaborations.
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June 17, 2025
Dr. ShinozakiĀ presentedĀ āGame changing approach for deliriumāĀ at the Division of Integrated Omics Research, Research Center for Experimental Modeling of Human Disease, Kanazawa University, Kanazawa, Japan.
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June 16, 2025
Dr. ShinozakiĀ presentedĀ āGame changing approach for deliriumāĀ at the Department of Psychiatry, Tokyo Medical and Dental University, Tokyo, Japan.
June 5th, 2025
Shinozaki Lab BBQ Party!
Welcome party for our new visiting scholar, Dr. Rika Sakuma, and also farewell party for our RA, Therese, who will be starting med school at UCSF this summer.
Welcome Rika!
We will miss you Therese, but you will be nearby, so we can get together again!
May 9th, 2025
A huge congratulations to the students of the Shinozaki Lab:Ā
Therese Santiago has been accepted to UCSF Medical School on a full-ride scholarship!Ā
Hieu Nguyen was recently awarded a highly competitive VPUE Grant to conduct research at the lab over the Summer!Ā
Nipun Gorantla was accepted to a competitive clinical internship at Johnson and Johnson for this Summer!Ā
Congratulations again to the Shinozaki Lab students, and we hope to see more great accomplishments to come!
February 28th, 2025
This week, we bid a warm farewell to Tsuyoshi, Tomo, and Takaya as they wrap up their time with us, and we welcome our newest lab members, Shota and Ilgin! To celebrate new beginnings and say thank you to our departing colleagues, we gathered for a sashimi party.Ā Here's to great memories, exciting futures, and the continued spirit of collaboration in our lab!
January 24, 2025
Dr. Shinozaki presented āGame changing approach for deliriumā at the Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN.
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January 23, 2025
Dr. Shinozaki delivered an inspiring lecture, āLife as a Physician-Scientist,ā at the Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN.
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January 14, 2025
Dr. Shinozaki presented āGame changing approach for deliriumā at the Department of Psychiatry and Behavioral Sciences, University of Texas Health Houston, McGovern Medical School, Houston, TX.
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