MIPs (Molecular Inversion Probe) in cancer
Computer Tomography showing liver metastases
Personnel
Hanlee Ji1
Mike Zhang
Jochen Kumm1
James Ford2
Kyle Farnam
Affiliation
1SGTC
2Stanford Oncology
Related Info
Potential application of MIP
To address this issue, we describe the potential application of the molecular inversion probe (MIP) assay in genome-wide detection of gene copy alterations in cancer. Molecular inversion probes combine quantitative DNA detection specificity and sensitivity with the potential to analyze large numbers of target sequences in parallel. For genome-wide gene copy number / allelic imbalance analysis, MIPs have many potential advantages over current high-throughput technologies, including the ability to interrogate gene copy number quantitatively at a large number of designated, unrestricted positions across the entire genome.