Ultra-high-resolution Diffusion MRI (dMRI)

dMRI is hampered by low-SNR & artifacts at high resolutions. We developed ‘gSLIDER’ acquisition and used it with ultra-high-strength gradient & AC/DC shim-array hardware to achieve > 10× smaller voxel size than in conventional dMRI.

Liao C, Bilgic B, Tian Q, Stockmann JP, Cao X, Fan Q, Iyer SS, Wang F, Ngamsombat C, Lo WC, Manhard MK, Huang SY, Wald LL, Setsompop K. Distortion-free, high-isotropic-resolution diffusion MRI with gSlider BUDA-EPI and multicoil dynamic B0 shimming. Magn Reson Med. 2021 Mar 10. doi: 10.1002/mrm.28748. [PMID 33748985]

Haldar JP, Liu Y, Liao C, Fan Q, Setsompop K. Fast submillimeter diffusion MRI using gSlider-SMS and SNR-enhancing joint reconstruction. Magn Reson Med. 2020 Aug;84(2):762-776. doi: 10.1002/mrm.28172. [PMC7968733]

Wang F, Bilgic B, Dong Z, Manhard MK, Ohringer N, Zhao B, Haskell M, Cauley SF, Fan Q, Witzel T, Adalsteinsson E, Wald LL, Setsompop K. Motion-robust sub-millimeter isotropic diffusion imaging through motion corrected generalized slice dithered enhanced resolution (MC-gSlider) acquisition. Magn Reson Med. 2018 Nov;80(5):1891-1906. doi: 10.1002/mrm.27196. [PMC6107445]

Setsompop K, Fan Q, Stockmann J, Bilgic B, Huang S, Cauley SF, Nummenmaa A, Wang F, Rathi Y, Witzel T, Wald LL. High-resolution in vivo diffusion imaging of the human brain with generalized slice dithered enhanced resolution: Simultaneous multislice (gSlider-SMS). Magn Reson Med. 2018 Jan;79(1):141-151. doi: 10.1002/mrm.26653. [PMC5585027]

Setsompop K, Kimmlingen R, Eberlein E, Witzel T, Cohen-Adad J, McNab JA, Keil B, Tisdall MD, Hoecht P, Dietz P, Cauley SF, Tountcheva V, Matschl V, Lenz VH, Heberlein K, Potthast A, Thein H, Horn JV, Toga A, Schmitt F, Lehne D, Rosen BR, Wedeen V, Wald LL. Pushing the limits of in vivo diffusion MRI for the Human Connectome Project. Neuroimage. 2013 Oct 15;80:220-33. doi: 10.1016/j.neuroimage.2013.05.078. [PMC3725309]

Setsompop K, Gagoski BA, Polimeni JR, Witzel T, Wedeen VJ, Wald LL. Blipped-controlled aliasing in parallel imaging for simultaneous multislice echo planar imaging with reduced g-factor penalty. Magn Reson Med. 2012 May;67(5):1210-24. doi: 10.1002/mrm.23097. [PMC3323676]