The research in our lab focuses on the development of new MRI acquisition technologies that can dramatically improve the speed, sensitivity and specificity of brain imaging. Our research explores approaches in designing tailored data acquisition & reconstruction algorithms using signal processing/optimization/ML methods, to take advantage of the underlying MR Physics and emerging hardware.
The goal is to create new imaging strategies that can help address important clinical & neuroscientific questions. The technologies that we have developed have enabled highly detailed brain data at unprecedented temporal and spatial resolutions, that have helped extract a wealth of quantitative information about brain structure and physiology. Some of these technologies have now been successfully translated as FDA-approved product, that are now being used daily in the clinic on the Siemens, GE and Phillips MRI scanners worldwide.
– Magn Reson MedIn Vivo Meso‐Scale Whole‐Brain Quantitative Imaging With Tailored MRF on the NexGen 7T Scanner
Purpose: To push the speed and resolution limit of in vivo quantitative imaging and enable estimation of quantitative tissue parameters of subtle brain structures that were previously difficult to as...
– Magn Reson MedThree‐dimensional high‐isotropic‐resolution MR fingerprinting optimized for 0.55 T
Purpose: To provide a fast quantitative imaging approach for a 0.55T scanner, where signal-to-noise ratio is limited by the field strength and k-space sampling speed is limited by a lower specificati...
– Magn Reson MedSpherical echo‐planar time‐resolved imaging (sEPTI) for rapid 3D quantitative T2* and susceptibility imaging
Purpose: To develop a 3D spherical EPTI (sEPTI) acquisition and a comprehensive reconstruction pipeline for rapid high-quality whole-brain submillimeter and QSM quantification.
– Magn Reson MedHigh‐resolution myelin‐water fraction and quantitative relaxation mapping using 3D ViSTa‐MR fingerprinting
Purpose: This study aims to develop a high-resolution whole-brain multi-parametric quantitative MRI approach for simultaneous mapping of myelin-water fraction (MWF), T1, T2, and proton-density (PD), all within a clinically feasible scan time.
