The research in our lab focuses on the development of new MRI acquisition technologies that can dramatically improve the speed, sensitivity and specificity of brain imaging. Our research explores approaches in designing tailored data acquisition & reconstruction algorithms using signal processing/optimization/ML methods, to take advantage of the underlying MR Physics and emerging hardware.
The goal is to create new imaging strategies that can help address important clinical & neuroscientific questions. The technologies that we have developed have enabled highly detailed brain data at unprecedented temporal and spatial resolutions, that have helped extract a wealth of quantitative information about brain structure and physiology. Some of these technologies have now been successfully translated as FDA-approved product, that are now being used daily in the clinic on the Siemens, GE and Phillips MRI scanners worldwide.
- – NeuroImage
High-fidelity mesoscale in-vivo diffusion MRI through gSlider-BUDA and circular EPI with S-LORAKS reconstruction
Purpose: To develop a high-fidelity diffusion MRI acquisition and reconstruction framework with reduced echo-train-length for less T2* image blurring compared to typical highly accelerated echo-planar imaging (EPI) acquisitions at sub-millimeter isotropic resolution.
- – PubMed Central (PMC)
Deep Learning Initialized Compressed Sensing (Deli-CS) in Volumetric Spatio-Temporal Subspace Reconstruction
Spatio-temporal MRI methods enable whole-brain multi-parametric mapping at ultra-fast acquisition times through efficient k-space encoding, but can have very long reconstruction times, which limit their integration into clinical practice.
- – Wiley Online Library
High‐resolution motion‐ and phase‐corrected functional MRI at 7 T using shuttered multishot echo‐planar imaging
Purpose: To achieve high-resolution multishot echo-planar imaging (EPI) for functional MRI (fMRI) with reduced sensitivity to in-plane motion and between-shot phase variations.
- – Nat Commun.
Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer’s disease
Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer’s Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others.
- – Eur Radiol
Validation of a highly accelerated post-contrast wave-controlled aliasing in parallel imaging (CAIPI) 3D-T1 MPRAGE compared to standard 3D-T1 MPRAGE for detection of intracranial enhancing lesions on 3-T MRI - European Radiology
Objectives: High-resolution post-contrast T1-weighted imaging is a workhorse sequence in the evaluation of neurological disorders. The T1-MPRAGE sequence has been widely adopted for the visualization of enhancing pathology in the brain. However, this three-dimensional (3D) acquisition is lengthy and prone to motion artifact, which often compromises diagnostic quality.
- – Radiology
Congratulations to Congyu Liao and Nan Wang for being selected as 2022 ISMRM Junior Fellows!
Congyu Liao, PhD, an Instructor in Radiology, and Nan Wang, PhD, a Postdoctoral Scholar, both in the Setsompop Lab, were inducted as Junior Fellows. The ISMRM Junior Fellow Program was established to recognize outstanding researchers and clinicians at an early stage in their careers, with an established and long-term commitment to ISMRM.
- – Doctoral Thesis: MRI techniques for quantitative and microstructure imaging
Congratulation to Zijing Dong for his successful thesis defense!
This thesis aims at overcoming these challenges and providing efficient microstructure imaging for the human brain with higher speed, SNR, resolution, and motion robustness. Thesis Supervisor(s): Kawin Setsompop, Elfar Adalsteinsson (co-advisor)
ISMRM quantitative MR Study Group - 2021 Best Abstract in the Validation category to Fuyixue Wang
Title: Fast and repeatable multi-parametric mapping using 3D Echo-Planar Time-resolved Imaging (3D-EPTI). Synopsis: 3D-EPTI is a recent multi-parametric mapping technique capable of rapid T1,T2,and T2* quantification. In this work, we characterize the repeatability of two optimized 3D-EPTI whole-brain protocols at 1-mm and 0.7-mm isotropic resolutions (3- and 9-minutes), suitable for a range of clinical and neuroscientific applications...
- – Harvard-MIT Health Sciences and Technology
Congratulations to Fuyixue Wang for completing her Medical Engineering and Medical Physics (MEMP) PhD program at MIT
Thesis: Spatiotemporal encoding methods for brain magnetic resonance imaging. Thesis Supervisor: Kawin Setsompop, PhD - Associate Professor of Radiology, Stanford University