The clinical relevance of necroinflammation
Oct 22, 2018 (Mon) | 3:00 PM -4:00 PM
Beckman Center, Room B200
: STANFORD, CA
Necroinflammation is defined as the inflammatory response to necrotic cell death. Different necrotic cell death pathways exhibit different immune responses, despite a comparable level of intracellular content release (referred to as damage associated molecular patterns or DAMPs). In addition to DAMP release, which is inevitably associated with necrotic cell death, the active production of pro-/anti-inflammatory cytokines characterizes certain necrotic pathways. Necroptosis, ferroptosis and pyroptosis, therefore, are immunogenic to a different extent. In this lecture, the focus will be on the clinical relevance of necroinflammation. Given the efforts to develop inhibitors of necrotic cell death (ferrostatins, necrostatins etc), it is likely that interference with necroinflammation reaches c
Department: Institute for Immunity, Transplantation and Infection
Contact: Michele King | 650 723 3084 | mking
Presenter(s):
- PD Dr. med. Andreas Linkermann, FASN Principle Investigator
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