Publications
Scientific publications using patient-derived iPSCs from the Stanford CVI Biobank
2023
Generation of two iPSC lines from long QT syndrome patients carrying SNTA1 variants. Jimenez-Tellez N, Vera CD, Yildirim Z, Guevara JV, Zhang T, Wu JC. Stem Cell Research 66 (2023): 103003
Generation of two human iPSC lines with exon 3 mutations in BCL2-associated athanogene 3 (BAG3) from dilated cardiomyopathy patients. Zushin PJH, Zhou Y, Li A, Ashley EA, Wheeler MT, Wu JC. Stem Cell Research 67 (2023): 103019
Generation of two induced pluripotent stem cell lines from spinal muscular atrophy type 1 patients carrying no functional copies of SMN1 gene. Zeng WS, Kong XH, Alamana C, Liu Y, Guzman J, Pang PD, Day JW, Wu JC. Stem Cell Research 69 (2023): 103095
2022
Heterozygous LMNA mutation-carrying iPSC line from three cardiac laminopathy patients. Cho S, Lee C, Lai C, Zhuge Y, Haddad F, Fowler M, Sallam K, Wu JC. Stem Cell Research 2022 Jan 03;59:102657
Generation of two iPSC lines from hypertrophic cardiomyopathy patients carrying MYBPC3 and PRKAG2 variants. Manhas A, Jahng JW, Vera CD, Shenoy SP, Knowles JW, Wu JC. Stem Cell Research 2022 May;61:102774. doi: 10.1016/j.scr.2022.102774
Generation of two induced pluripotent stem cell lines carrying the phospholamban R14del mutation for modeling ARVD/C. Vera CD, Manhas A, Shenoy SP, Wheeler MT, Sallam K, Wu JC. Stem Cell Research 2022 Jun 6;63:102834. doi: 10.1016/j.scr.2022.102834
The effects of xeno-free cryopreservation on the contractile properties of human iPSC derived cardiomyocytes. Orlando Chirikia, Samuel D. Feinstein, Mohamed A. Faynus, Anna A. Kim, Kerry V. Lane, Gabriela V. Torres, Jeffrey V. Pham, Zachary Singh, Amanda Nguyen, Dilip Thomas, Dennis O. Clegg, Joseph C. Wu, Beth L. Pruitt. Journal of Molecular and Cellular Cardiology 2022 July v168:p107-114
Generation of human induced pluripotent stem cell lines carrying heterozygous PLN mutation from dilated cardiomyopathy patients. Caudal A, Mondéjar-Parreño G, Vera CD, Williams DR, Shenoy SP, Liang D, Wu JC. Stem Cell Research 63 (2022):102855
Heterozygous LMNA mutation-carrying iPSC lines from three cardiac laminopathy patients. Cho S, Lee C, Lai C, Zhuge Y, Haddad F, Fowler M, Sallam K, Wu JC. Stem Cell Research 59 (2022): 102657
Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients carrying heterozygous FLNC mutations. Kojic A, Kim H, Guevara JV, Ravada S, Sallam K, Wu JC. Stem Cell Research 64 (2022): 102928
Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients carrying TTN mutations. Zhang T, Zhao S, Alamana C, Shen MC, Parikh V, Wheeler MT, Wu JC. Stem Cell Research 65 (2022): 102941
Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients caused by heterozygous mutations in the HCN4 gene. Yildirim Z, Kokic A, Yan C, Wu MA, Vagelos R, Wu JC. Stem Cell Research 65 (2022): 102951
The effects of xeno-free cryopreservation on the contractile properties of human iPSC derived cardiomyocytes. Orlando Chirikia, Samuel D. Feinstein, Mohamed A. Faynus, Anna A. Kim, Kerry V. Lane, Gabriela V. Torres, Jeffrey V. Pham, Zachary Singh, Amanda Nguyen, Dilip Thomas, Dennis O. Clegg, Joseph C. Wu, Beth L. Pruitt. Journal of Molecular and Cellular Cardiology 2022 July v168:p107-114
Generation of three induced pluripotent stem cell lines to model and investigate diseases affecting Hispanics. Chen Ian Y, Olshausen J, Thomas D, Lai C, McLaughlin TL, Wu JC. Stem Cell Research 65 (2022): 102969
2021
Generation of three induced pluripotent stem cell lines from hypertrophic cardiomyopathy patients carrying TNNI3 mutations. Zhao S, Shen MC, Lee C, Zha YJ, Guevara JV, Wheeler MT, Wu JC. Stem Cell Research 2021 Dec. 57:102597
Generation of two heterozygous MYBPC3 mutation-carrying human iPSC lines, SCVIi001-A and SCVIi002-A, for modeling hypertrophic cardiomyopathy. Liu L, Shenoy SP, Jahng JWS, Liu Y, Knowles JW, Zhuge Y, Wu JC. Stem Cell Res. 2021 05;53:102279.
Generation of three induced pluripotent stem cell lines, SCVIi003-A, SCVIi004-A, SCVIi005-A, from patients with ARVD/C caused by heterozygous mutations in the PKP2 gene. Jahng JWS, Black KE, Liu L, Bae HR, Perez M, Ashley EA, Sallam K, Wu JC. Stem Cell Res. 2021 05;53:102284.
Generation of three heterozygous KCNH2 mutation-carrying human induced pluripotent stem cell lines for modeling LQT2 syndrome. Mondéjar-Parreño G, Jahng JWS, Belbachir N, Wu BC, Zhang X, Perez MV, Badhwar N, Wu JC. Stem Cell Res. 2021 07;54:102402.
Generation of three induced pluripotent stem cell lines (SCVIi014-A, SCVIi015-A, and SCVIi016-A) from patients with LQT1 caused by heterozygous mutations in the KCNQ1 gene. Zhang H, Jahng JWS, Liu Y, Chase AJ, Perez MV, Wu JC. Stem Cell Res. 2021 08;55:102492.
Generation of three induced pluripotent stem cell lines from hypertrophic cardiomyopathy patients carrying MYH7 mutations. Cao X, Jahng JWS, Lee C, Zha Y, Wheeler MT, Sallam K, Wu JC. Stem Cell Res. 2021 08;55:102455.
Generation of three induced pluripotent stem cell lines from hypertrophic cardiomyopathy patients carrying TNNI3 mutations. Zhao S, Shen MC, Lee C, Zha YJ, Guevara JV, Wheeler MT, Wu JC. Stem Cell Res. 2021 Dec. 57:102597
Generation of two induced pluripotent stem cell lines from Brugada syndrome affected patients carrying SCN5A mutations. Belbachir N, Lai C, Rhee JW, Zhuge Y, Perez MV, Sallam K, Wu JC. Stem Cell Res. 57 (2021) 102605
2020
Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy. Sayed, Nazish et al., Science Translational Medicine 2020 Jul 29;12(554)
RNA Sequencing Analysis of Induced Pluripotent Stem Cell-Derived Cardiomyocytes From Congenital Heart Disease Patients. Kitani, Tomoya et al., Circulation Research 2020;126:923-925
2019
A premature termination codon mutation in MYBPC3 causes hypertrophic cardiomyopathy via chronic activation of nonsense-mediated decay. Seeger T et al., Circulation 2019;139(6):799-811.
Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients. Wu, Haodi et al., European Heart Journal 2019;40(45):3685-3695.
2018
Determining the Pathogenicity of a Genomic Variant of Uncertain Significance Using CRISPR/Cas9 and Human-Induced Pluripotent Stem Cells. Ma, Ning et al., Circulation 2018;138:2666-2681
2017
A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell–Based Models for Cardiovascular Diseases. Karakikes et al., Circulation Research 2017 May 12;120(10):1561-1571
2012
Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy. Sun, Ning et al. Science Translational Medicine 2012 Apr 18;4(130):130ra47