Down's Syndrome Models

Ts65Dn (B6EiC3Sn-a/A-Ts (1716)65Dn)

Ts65Dn mice are the most commonly used mouse model of Down Syndrome (DS). This mouse is generated by Robertsonian segmental translocation of mouse chromosome 16 (MMU16) to the MMU17 centromere1. This chromosomal segment contains an extra copy of more than 100 gene homologues to HSA212,3,4. Ts65Dn mice have shorter life expectancies and show morphological, neurological, and structural abnormalities that parallel those found in patients with DS5,6,7,8,9,10,11,12.