Wire Hang Test

The Wire Hang test seeks to evaluate motor function and deficit in rodent models of CNS disorders. The test begins with the animal hanging from an elevated wire cage top. The animal is placed on the cage top, which is then inverted and suspended above the home cage; the latency to when the animal falls is recorded. This test is performed three days per week with three trials per session. The average performance for each session is presented as the average of the three trials. Testing typically lasts one week, but can continue up to three weeks. This test is used to phenotype strains of transgenic mice and evaluate novel chemical entities for their effect on motor performance.