Neurological Testing

Two main neurological tests are used to assess motor and behavioral deficits in rat models of CNS disorders. Both the Garcia test and the 28-point Neuroscore test involve a battery of motor tests, ranging from simple observation to traversing a horizontal bar. These tests are well-suited for assessing neurological damage due to ischemia and the effects of novel chemical entities on motor performance.

Garcia Test  The Garcia test is a composite neurological test in which the rats are evaluated for various sensorimotor deficits. The 6 tests used are as follows:

  1. Spontaneous activity
  2. Symmetry in four limb movement
  3. Forepaw outstretching
  4. Climbing
  5. Body proprioception
  6. Response to vibrissae touch

Maximum score: 18 points

28-Point Neuroscore: A 28-point Neuroscore test is used to assess post-ischemic motor and behavioral deficits. The following parameters are analyzed:

  • Circling
  • Motility
  • General condition
  • Righting reflex
  • Paw placement
  • Behavior on a horizontal bar
  • Behavior on an inclined platform
  • Grip strength
  • Contralateral reflex
  • Visual forepaw reaching
  • Contralateral rotation

Maximum score : 28 points