10:00 AM - 11:00 AM
Iron imaging in myocardial infarction reperfusion injury
RSL Future Leaders Seminar Series
Restoration of coronary blood flow after a heart attack can cause reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and heart failure. Iron is an essential biometal that may have a pathologic role in this process. There is a clinical need for a precise noninvasive method to detect iron for risk stratification of patients and therapy evaluation. Here, we report that magnetic susceptibility imaging in a large animal model shows an infarct paramagnetic shift associated with duration of coronary artery occlusion and the presence of iron. Iron validation techniques used include histology, immunohistochemistry, spectrometry and spectroscopy. Further mRNA analysis shows upregulation of ferritin and heme oxygenase. While conventional imaging corroborates the findings of iron deposition, magnetic susceptibility imaging has improved sensitivity to iron and mitigates confounding factors such as edema and fibrosis. Myocardial infarction patients receiving reperfusion therapy show magnetic susceptibility changes associated with hypokinetic myocardial wall motion and microvascular obstruction, demonstrating potential for clinical translation.
Moon BF, Iyer SK, Hwuang E, Solomon MP, Hall AT, Kumar R, Josselyn N, Higbee-Dempsey, Tsourkas A, Imai A, Okamoto K, Saito Y, Pilla JJ, Gorman JH, Gorman RC, Tschabrunn C, Keeney SJ, Castillero E, Ferrari G, Jockusch S, Wehrli FW, Shou H, Ferrari VA, Han Y, Gulhane A, Litt H, Matthai W, Witschey WR. Iron imaging in myocardial infarction reperfusion injury. Nat Commun. 2020 Jun 29;11(1):3273. doi: 10.1038/s41467-020-16923-0. [PMID 32601301; PMC7324567].
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1201 Welch Road
Palo Alto, CA 94305
Lucas Center for Imaging1201 Welch Road
Palo Alto CA, 94305
Brianna Moon, PhD
Brianna Moon recently earned her Ph.D. in bioengineering as a Medical Imaging Interfaces Scholar in the Advanced Cardiovascular Imaging Lab at the University of Pennsylvania advised by Dr. Walter Witschey. Through the Interfaces program she completed the didactic medical school curriculum at the Perelman School of Medicine. Her thesis work focused on imaging iron in myocardial infarction reperfusion injury using quantitative susceptibility mapping in a large animal study and in STEMI patients. Upon graduating she joined Dr. Peter Caravan’s research team at the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital. Brianna received her B.S. in Biomedical Engineering, Summa Cum Laude, at the University of Arizona, where she was a MARC trainee and part of the Contrast Agent Molecular Engineering Laboratory. Over the years, her work and collaboration have culminated into several peer-reviewed articles including a first-authored Nature Communications publication.