Reversed metabolic reprogramming as a measure of cancer treatment efficacy in rat C6 glioma model

Summary

Tumor metabolism shifts from oxidative phosphorylation to inefficient glycolysis resulting in overproduction of lactate (Warburg effect), and cancers may be effectively treated if this imbalance were corrected. The aim of this longitudinal study of glioblastoma in a rat model was to determine whether the ratio of lactate (surrogate marker for glycolysis) to bicarbonate (for oxidative phosphorylation), as measured via in vivo magnetic resonance imaging of hyperpolarized 13C-labeled pyruvate accurately predicts survival. We found that, following lthe bolus injection of hyperpolarized 13C-labeled pyruvate, the resulting  13C Lactate to 13C Bicarbonate ratio (Lac/Bic) at 48 hours post-treatment is highly predictive of survival (p = 0.003). These results suggest a potential role for the 13C Lac/Bic ratio serving as a valuable measure of tumor metabolism and predicting therapeutic response.

Figure

Datta K, Lauritzen MH, Merchant M, Jang T, Liu SC, Hurd R, Recht L, Spielman DM. Reversed metabolic reprogramming as a measure of cancer treatment efficacyin rat C6 glioma model. PLoS One. 2019 Dec 12;14(12):e0225313. doi:10.1371/journal.pone.0225313. PMID: 31830049; PMCID: PMC6907781.