MRI of [2-13C] Lactate without J-coupling artifacts


Imaging of [2‐13C]lactate, a metabolic product of [2‐13C]pyruvate, is of considerable interest in hyperpolarized 13C studies. However, artifact‐free imaging of a J‐coupled nuclear spin species can be challenging due to the peak‐splitting induced by the spin‐spin interactions. In this work, two new techniques resolving these J‐modulated artifacts are presented. Quadrature imaging and the narrowband excitation techniques are shown to resolve the J‐coupling induced ghosting and blurring artifacts present with conventional MRI of J‐coupled signals such as [2‐13C]lactate.


Datta K, Spielman D. MRI of [2-13C] Lactate without J-coupling artifacts. Magn Reson Med. 2020 Oct 15. doi: 10.1002/mrm.28532. Epub ahead of print. PMID: 33058240.