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Research Interests

With a research background in molecular biology, bioengineering, and immunology, I am generally interested in understanding how biological systems can be modulated to restore or develop novel function in the context of disease. As a postdoc in the Roncarolo lab, I am working to optimize the LV-10 Tr1 induction and expansion protocol for clinical use and compare the survival, safety, and efficacy of alloantigen-specific vs polyclonal cell products. I am also interested in developing a nanoparticle-based artificial antigen presenting cell system to expand Tr1 cell cultures and interrogate the signaling requirements that control Tr1 identity.

Publications

1. Roelants FM, Leskoske KL, Pedersen RT, Muir A, Liu JM, Finnigan GC, Thorner J. TOR Complex 2-Regulated Protein Kinase Fpk1 Stimulates Endocytosis via Inhibition of Ark1/Prk1-Related Protein Kinase Akl1 in Saccharomyces cerevisiae. Mol Cell Biol. 2017 Apr 1; 37(7): e00627-16
2. Liu JMH, Zhang J, Zhang X, Hlavaty KA, Ricci, CF, Leonard JN, Shea LD, Gower RM. Transforming growth factor-beta 1 delivery from microporous scaffolds decreases inflammation post-implant and enhances function of transplanted islets. Biomaterials. 2016 Feb;80:11–19.