About
Obsessive-compulsive disorder (OCD) was described as early as the seventeenth century, when the Oxford Don, Robert Burton, reported a case in his compendium, The Anatomy of Melancholy (1621). Modern concepts of OCD began to evolve in France and Germany in the nineteenth century. In the late twentieth century we have begun to understand the biology of this mental disorder, as neurochemical assay and brain imaging techniques have become available.