LOSS Clinical Study

Neural Mechanisms of Decision Making in Hoarding Disorder

about the loss study

Hoarding disorder (HD) is a highly disabling condition in which individuals have persistent difficulty parting with personal possessions (i.e. loss aversion), which results in clutter and inability to use the rooms in the home for their intended use. It causes public health problems when clutter leads to pest infestations or obstructs fire exits in apartment buildings, endangering both personal and neighbors’ safety. There are currently no FDA approved drugs for hoarding disorder, perhaps because there is limited information on HD's underlying mechanisms.

This project will test the neural and behavioral correlates of loss aversion in HD, providing the first test of our novel model for the underlying neural mechanisms of HD.

Purpose: The overall goal of this project is to test a novel model for the underlying neural mechanisms of hoarding disorder. To accomplish this, we will assess loss aversion-related behavior and neural activation in participants suffering from hoarding disorder, and healthy participants.

This study is listed on ClinicalTrials.gov.

participate in loss study

The Rodriguez Lab is looking for adults 18-70 years old with difficulty in discarding items to take part in a study providing these possible benefits:

  • Free diagnostic evaluation
  • Free test of your memory and attention
  • Compensation up to $50

You can participate if:

  • You are between the ages of 18-70
  • You are acquiring items and have difficulty to discard them
  • You are willing and able to understand and complete consent procedures 
  • You have the capacity to provide informed consent

You cannot participate if:

  • You are pregnant or nursing female
  • You have major medical or neurological condition that will make your participation unsafe
  • You have metallic device or dental braces that will prevent you from receiving an MRI scan

Duration of Study Involvement

  • Each individual will participate in a free diagnostic evaluation by experienced clinicians
  • If eligible, the study will involve a single (1) in-person visit of 3-4 hours

Contact us


401 Quarry Rd

Stanford, CA 94305-5715



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