DoD Amyotrophic Lateral Sclerosis Research Program

DoD Amyotrophic Lateral Sclerosis Research Program 
Therapeutic Development Award
Amount of funding: Direct costs budgeted will not exceed $1,000,000.
Purpose:  The FY21 ALSRP Therapeutic Development Award supports research ranging from validation of therapeutic leads through U.S. Food and Drug Administration (FDA) Investigational New Drug (IND)-enabling studies. The proposed studies are expected to be empirical in nature and product-driven. Applicants with limited ALS experience are strongly encouraged to include collaborators with substantial experience in the relevant ALS model systems, endpoints, and pathophysiology. 
Eligibility: Independent investigators - Faculty with PI eligibility and CE faculty (with an approved CE faculty PI waiver obtained through their RPM in RMG prior to the pre-application/letter of intent) may be the PI.
Not eligible: Instructors, Clinical Instructors, Academic staff-research (i.e., research associates), and postdocs are not eligible for this RFP because Stanford does not consider them to be independent positions.
Timeline:
Pre-application/Letter of intent (required) deadline: April 9, 2021 via eBrap
Please include your RPM’s name as business official in the pre-application.
Institutional representative (RPM/RMG or CGO/OSR) deadline: July 8, 2021
Full proposal deadline: July 15, 2021 via grants.gov
Guidelines: https://cdmrp.army.mil/funding/alsrp

DoD Amyotrophic Lateral Sclerosis Research Program 
Therapeutic Idea Award
Amount of funding: Direct costs budgeted will not exceed $500,000.
Purpose:  The FY21 ALSRP Therapeutic Idea Award supports hypothesis-driven therapeutic development and is designed to promote new ideas aimed at drug or treatment discovery that are still in the early stages of development. Development and/or modification of preclinical model systems or the application of high-throughput screens to define or assess lead compounds for ALS treatment may also be proposed. All research projects should include a well-formulated, testable hypothesis based on strong scientific rationale that holds translational potential to improve ALS treatment and/or advance a novel treatment modality. Preliminary data are not required.
Eligibility: Independent investigators - Faculty with PI eligibility and CE faculty (with an approved CE faculty PI waiver obtained through their RPM in RMG prior to the pre-application/letter of intent) may be PI. Early career investigators (defined as independent, non-mentored investigators within 5 years of their last training position e.g., postdoctoral fellowship, medical residency, clinical fellowship as of the application submission deadline) are encouraged to apply.
Not eligible: Instructors, Clinical Instructors, Academic staff-research (i.e., research associates), and postdocs are not eligible for this RFP because Stanford does not consider them to be independent positions.
Timeline:
Pre-application/Letter of intent (required) deadline: April 9, 2021 via eBrap
Please include your RPM’s name as business official in the pre-application.
Institutional representative (RPM/RMG or CGO/OSR) deadline: July 8, 2021
Full proposal deadline: July 15, 2021 via grants.gov
Guidelines: https://cdmrp.army.mil/funding/alsrp

DoD Amyotrophic Lateral Sclerosis Research Program 
Therapeutic Development Award
Amount of funding: Direct costs budgeted will not exceed $300,000.
Purpose: The intent of the FY21 ALSRP Clinical Development Award is to support correlative studies leveraging human-based ALS resources to enrich clinical trials or to optimize components of current ALS clinical care. Leveraging can refer to the use of existing well-characterized and highly curated resources or collaboration with ongoing clinical research to amplify potential gains in knowledge. Analysis of results and/or biosamples collected under these projects should be made broadly available through deposition in existing publicly available curated repositories and data platforms. 
Eligibility: Independent investigators - Faculty with PI eligibility and CE faculty (with an approved CE faculty PI waiver obtained through their RPM in RMG prior to the pre-application/letter of intent) may be PI. Early career investigators (defined as independent, non-mentored investigators within 5 years of their last training position e.g., postdoctoral fellowship, medical residency, clinical fellowship as of the application submission deadline) are encouraged to apply.
Not eligible: Instructors, Clinical Instructors, Academic staff-research (i.e., research associates), and postdocs are not eligible for this RFP because Stanford does not consider them to be independent positions.
Timeline:
Pre-application/Letter of intent (required) deadline: April 9, 2021 via eBrap
Please include your RPM’s name as business official in the pre-application.
Institutional representative (RPM/RMG or CGO/OSR) deadline: July 8, 2021
Full proposal deadline: July 15, 2021 via grants.gov
Guidelines: https://cdmrp.army.mil/funding/alsrp

DoD Amyotrophic Lateral Sclerosis Research Program
Therapeutic/Biomarker Pilot Trial Award
Amount of funding: Direct costs budgeted will not exceed $2,000,000.
Purpose: The ALSRP Therapeutic/Biomarker Pilot Trial Award supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of ALS. Clinical trials may be designed to evaluate promising drugs, biologics, or devices with anticipated therapeutic impact that is supported by strong scientific rationale and existing preclinical data. Projects may range from Phase 1 to small-scale Phase 2 trials and should be designed to de-risk and inform the design of more advanced trials, by investigating safety, feasibility, biomarker application, and therapeutic efficacy in relevant patient populations.
Eligibility: Independent investigators - Faculty with PI eligibility and CE faculty (with an approved CE faculty PI waiver obtained through their RPM in RMG prior to the pre-application/letter of intent) may be PI. Early career investigators (defined as independent, non-mentored investigators within 5 years of their last training position e.g., postdoctoral fellowship, medical residency, clinical fellowship as of the application submission deadline) are encouraged to apply.
Not eligible: Instructors, Clinical Instructors, Academic staff-research (i.e., research associates), and postdocs are not eligible for this RFP because Stanford does not consider them to be independent positions.
Timeline:
Pre-application/Letter of intent (required) deadline: April 9, 2021 via eBrap
Please include your RPM’s name as business official in the pre-application.
Institutional representative (RPM/RMG or CGO/OSR) deadline: July 8, 2021
Full proposal deadline: July 15, 2021 via grants.gov
Guidelines: https://cdmrp.army.mil/funding/alsrp

Please include your institutional official's name (RPM/RMG or CGO/OSR) as business official in the pre-application/LOI.

eBRAP Funding Opportunities and Forms (including the General Application Instructions).