DoD Amyotrophic Lateral Sclerosis Research Program

Amount of funding: Total costs budgeted for the entire period of performance will not exceed $2M.
Purpose: The FY25 ALSRP Therapeutic Development Award supports research ranging from preclinical validation of therapeutic leads through FDA IND-enabling studies. The proposed studies are expected to be empirical in nature and product driven. Applicants with limited ALS experience are strongly encouraged to include collaborators with substantial experience in the relevant ALS model systems, endpoints, and pathophysiology.
Eligibility: Independent investigators - Faculty with PI eligibility and CE faculty (with an approved CE faculty PI waiver obtained through their RPM in RMG prior to the pre-application/letter of intent) may be PI. 
Timeline:
REQUIRED Pre-Application (Pre-Proposal) Deadline: June 6, 2025 via eBrap
Please include your RPM’s name as business official in the pre-application.
Institutional representative (RPM/RMG or CGO/OSR) Deadline:  August 20, 2025
Application Submission Deadline: August 27, 2025 via grants.gov
Guidelines: https://ebrap.org/eBRAP/public/ProgramFY.htm?programFYId=663102

Amount of funding: Total costs budgeted for the entire period of performance will not exceed $840,000.
Purpose: The FY25 ALSRP Therapeutic Idea Award (TIA) supports new, innovative, high-risk, high-gain ideas aimed at Amyotrophic Lateral Sclerosis (ALS) drug or therapy discovery. The studies supported by this award mechanism are expected to be hypothesis-driven and generate preliminary data for future avenues of therapeutic investigation.
Eligibility: Independent investigators - Faculty with PI eligibility and CE faculty (with an approved CE faculty PI waiver obtained through their RPM in RMG prior to the pre-application/letter of intent) may be PI. 
Timeline:
REQUIRED Pre-Application (Pre-Proposal) Deadline: June 6, 2025 via eBrap
Please include your RPM’s name as business official in the pre-application.
Institutional representative (RPM/RMG or CGO/OSR) Deadline:  August 20, 2025
Application Submission Deadline: August 27, 2025 via grants.gov
Guidelines: https://ebrap.org/eBRAP/public/ProgramFY.htm?programFYId=663102

Amount of funding: Total costs budgeted for the entire period of performance will not exceed $2.8M.
Purpose: The FY25 ALSRP Pilot Clinical Trial Award supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or symptom management of ALS. Proposed projects may range from phase 1 to small-scale phase 2 trials.
Eligibility: Independent investigators - Faculty with PI eligibility and CE faculty (with an approved CE faculty PI waiver obtained through their RPM in RMG prior to the pre-application/letter of intent) may be PI. 
Timeline:
REQUIRED Pre-Application (Pre-Proposal) Deadline: June 6, 2025 via eBrap
Please include your RPM’s name as business official in the pre-application.
Institutional representative (RPM/RMG or CGO/OSR) Deadline:  August 20, 2025
Application Submission Deadline: August 27, 2025 via grants.gov
Guidelines: https://ebrap.org/eBRAP/public/ProgramFY.htm?programFYId=663102

Amount of funding: Total costs budgeted for the entire period of performance will not exceed $1M.
Purpose: The FY25 ALSRP COBA supports the development and/or validation of clinical outcomes and biomarkers to enrich clinical trials in Amyotrophic Lateral Sclerosis (ALS). Projects can be relevant to a specific therapy, a class of therapeutics, or to a specific ALS subtype (such as  a particular genetic mutation) and do not have to broadly apply to all patients.
Eligibility: Independent investigators - Faculty with PI eligibility and CE faculty (with an approved CE faculty PI waiver obtained through their RPM in RMG prior to the pre-application/letter of intent) may be PI. 
Timeline:
REQUIRED Pre-Application (Pre-Proposal) Deadline: June 6, 2025 via eBrap
Please include your RPM’s name as business official in the pre-application.
Institutional representative (RPM/RMG or CGO/OSR) Deadline:  August 20, 2025
Application Submission Deadline: August 27, 2025 via grants.gov
Guidelines: https://ebrap.org/eBRAP/public/ProgramFY.htm?programFYId=663102

Please include your institutional official's name (RPM/RMG or CGO/OSR) as business official in the pre-application/LOI.

eBRAP Funding Opportunities and Forms (including the General Application Instructions).