Publications

Plasma Proteomics of the Fontan Circulation Reveal Signatures of Oxidative Stress and Cell Death

Lecointe J, Gan S, Tripathi D, Ichimura S, Clouthier KL, Kushwaha A, Mercer-Rosa L, Reddy S. Plasma Proteomics of the Fontan Circulation Reveal Signatures of Oxidative Stress and Cell Death. Circ Heart Fail. 2025 May;18(5):e012136. doi: 10.1161/CIRCHEARTFAILURE.124.012136. Epub 2025 Apr 16. PMID: 40235440; PMCID: PMC12084025

Abnormalities in Coronary Microvasculature in Pulmonary Atresia With Intact Ventricular Septum

Vincent AGB, Ichimura K, Ichimura S, Alden AO, Price E, Salmi D, Kushwaha A, Spiekerkoetter E, Reddy S. Abnormalities in Coronary Microvasculature in Pulmonary Atresia With Intact Ventricular Septum. Circ Cardiovasc Imaging. 2025 Apr;18(4):e017415. doi: 10.1161/CIRCIMAGING.124.017415. Epub 2024 Nov 26. PMID: 39588635; PMCID: PMC11999784

Cardiorenal Syndrome in Right Heart Failure Due to Pulmonary Arterial Hypertension-The Right Ventricle as a Therapeutic Target to Improve Renal Function

Ichimura K, Gross A, Mathew RO, Salman L, Reddy S, Spiekerkoetter E, Sidhu MS. Cardiorenal Syndrome in Right Heart Failure Due to Pulmonary Arterial Hypertension-The Right Ventricle as a Therapeutic Target to Improve Renal Function. Cardiovasc Drugs Ther. 2025 Apr;39(2):373-384. doi: 10.1007/s10557-024-07588-8. Epub 2024 Jun 7. PMID: 38847906

3D Imaging Reveals Complex Microvascular Remodeling in the Right Ventricle in Pulmonary Hypertension.

Ichimura K, Boehm M, Andruska AM, Zhang F, Schimmel K, Bonham S, Kabiri A, Kheyfets VO, Ichimura S, Reddy S, Mao Y, Zhang T, Wang G, Santana EJ, Tian X, Essafri I, Vinh R, Tian W, Nicolls MR, Yajima S, Shudo Y, MacArthur JW, Woo YJ, Metzger RJ, Spiekerkoetter E. Circ Res. 2024 May 21. doi: 10.1161/CIRCRESAHA.123.323546. Online ahead of print. PMID:38770652  

Effect of Sodium-Glucose Cotransporter 2 Inhibitors in Adults With Congenital Heart Disease.

Neijenhuis RML, MacDonald ST, Zemrak F, Mertens BJA, Dinsdale A, Hunter A, Walker NL, Swan L, Reddy S, Rotmans JI, Jukema JW, Jongbloed MRM, Veldtman GR, Egorova AD. J Am Coll Cardiol. 2024 Apr 16;83(15):1403-1414. doi: 10.1016/j.jacc.2024.02.017. Epub 2024 Mar 25. PMID: 38530688

Mitochondrial Targeted Therapies to Prevent Maternal Diabetes-Induced Congenital Heart Defects.

Reddy S. JACC Basic Transl Sci. 2024 Mar 28;9(3):319-321. doi: 10.1016/j.jacbts.2024.01.016. eCollection 2024 Mar.PMID: 38559633 

MicroRNA-34a-Dependent Attenuation of Angiogenesis in Right Ventricular Failure.

Reddy S, Hu DQ, Zhao M, Ichimura S, Barnes EA, Cornfield DN, Alejandre Alcázar MA, Spiekerkoetter E, Fajardo G, Bernstein D. J Am Heart Assoc. 2024 Feb 6;13(3):e029427. doi: 10.1161/JAHA.123.029427. Epub 2024 Jan 31.PMID: 38293915

Tetralogy of Fallot Across the Lifespan: A Focus on the Right Ventricle.

Ganni E, Ho SY, Reddy S, Therrien J, Kearney K, Roche SL, Dimopoulos K, Mertens LL, Bitterman Y, Friedberg MK, Saraf A, Marelli A, Alonso-Gonzalez R. CJC Pediatr Congenit Heart Dis. 2023 Oct 20;2(6Part A):283-300. doi: 10.1016/j.cjcpc.2023.10.009. eCollection 2023 Dec.PMID: 38161676

A Noninvasive Circulating Signature of Combined Right Ventricular Pressure and Volume Overload in Tetralogy of Fallot/Pulmonary Atresia/Major Aortopulmonary Collateral Arteries.

Clouthier KL, Taylor AC, Xuhuai J, Liu Y, Parker S, Van Eyk J, Reddy S. World J Pediatr Congenit Heart Surg. 2023 Dec 21:21501351231213626. doi: 10.1177/21501351231213626. Online ahead of print.PMID: 38128927

Biomarkers, Socioeconomic Factors, and Right Ventricular Function After Surgical Repair for Tetralogy of Fallot.

Jones AL, Faerber J, Huang J, Ampah S, Wang Y, DeCost G, Gardner M, Naim MY, Reddy S, Goldmuntz E, Mercer-Rosa L. Pediatr Cardiol. 2023 Aug;44(6):1232-1241. doi: 10.1007/s00246-023-03108-x. Epub 2023 Feb 16.PMID: 36797379

miR Profile of Chronic Right Ventricular Pacing: a Pilot Study in Children with Congenital Complete Atrioventricular Block.

Navarre BM, Clouthier KL, Ji X, Taylor A, Weldy CS, Dubin AM, Reddy S. J Cardiovasc Transl Res. 2023 Apr;16(2):287-299. doi: 10.1007/s12265-022-10318-w. Epub 2022 Sep 19.PMID: 36121621

Cardiac Fibrosis in the Pressure Overloaded Left and Right Ventricle as a Therapeutic Target.

Schimmel K, Ichimura K, Reddy S, Haddad F, Spiekerkoetter E. Front Cardiovasc Med. 2022 May 6;9:886553. doi: 10.3389/fcvm.2022.886553. eCollection 2022.PMID: 35600469

iPSC model of congenital heart disease predicts disease outcome.

Tripathi D, Reddy S. Cell Stem Cell. 2022 May 5;29(5):659-660. doi: 10.1016/j.stem.2022.04.010.PMID: 35523134

Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy.

Ranjbarvaziri S, Kooiker KB, Ellenberger M, Fajardo G, Zhao M, Vander Roest AS, Woldeyes RA, Koyano TT, Fong R, Ma N, Tian L, Traber GM, Chan F, Perrino J, Reddy S, Chiu W, Wu JC, Woo JY, Ruppel KM, Spudich JA, Snyder MP, Contrepois K, Bernstein D. Circulation. 2021 Nov 23;144(21):1714-1731. doi: 10.1161/CIRCULATIONAHA.121.053575. Epub 2021 Oct 21.PMID: 34672721

Improving Right Ventricular Function by Increasing BMP Signaling with FK506.

Boehm M, Tian X, Ali MK, Mao Y, Ichimura K, Zhao M, Kuramoto K, Dannewitz Prosseda S, Fajardo G, Dufva MJ, Qin X, Kheyfets VO, Bernstein D, Reddy S, Metzger RJ, Zamanian RT, Haddad F, Spiekerkoetter E. Am J Respir Cell Mol Biol. 2021 Sep;65(3):272-287. doi: 10.1165/rcmb.2020-0528OC.PMID: 33938785

Transcriptomic and Functional Analyses of Mitochondrial Dysfunction in Pressure Overload-Induced Right Ventricular Failure.

Hwang HV, Sandeep N, Nair RV, Hu DQ, Zhao M, Lan IS, Fajardo G, Matkovich SJ, Bernstein D, Reddy S. J Am Heart Assoc. 2021 Feb 16;10(4):e017835. doi: 10.1161/JAHA.120.017835. Epub 2021 Jan 30.PMID: 33522250

Diagnosis and treatment of right ventricular dysfunction in congenital heart disease.

Santens B, Van De Bruaene A, De Meester P, D'Alto M, Reddy S, Bernstein D, Koestenberger M, Hansmann G, Budts W. Cardiovasc Diagn Ther. 2020 Oct;10(5):1625-1645. doi: 10.21037/cdt-20-370.PMID: 33224777

Circulating whole genome miRNA expression corresponds to progressive right ventricle enlargement and systolic dysfunction in adults with tetralogy of Fallot.

Weldy CS, Syed SA, Amsallem M, Hu DQ, Ji X, Punn R, Taylor A, Navarre B, Reddy S. PLoS One. 2020 Nov 11;15(11):e0241476. doi: 10.1371/journal.pone.0241476. eCollection 2020.PMID: 33175850

Noncanonical WNT Activation in Human Right Ventricular Heart Failure.

Edwards JJ, Brandimarto J, Hu DQ, Jeong S, Yucel N, Li L, Bedi KC Jr, Wada S, Murashige D, Hwang HTV, Zhao M, Margulies KB, Bernstein D, Reddy S, Arany Z. Front Cardiovasc Med. 2020 Oct 7;7:582407. doi: 10.3389/fcvm.2020.582407. eCollection 2020.PMID: 33134326

4HNE Impairs Myocardial Bioenergetics in Congenital Heart Disease-Induced Right Ventricular Failure.

Hwang HV, Sandeep N, Paige SL, Ranjbarvaziri S, Hu DQ, Zhao M, Lan IS, Coronado M, Kooiker KB, Wu SM, Fajardo G, Bernstein D, Reddy S. Circulation. 2020 Oct 27;142(17):1667-1683. doi: 10.1161/CIRCULATIONAHA.120.045470. Epub 2020 Aug 18.PMID: 32806952

Proceedings From the 2019 Stanford Single Ventricle Scientific Summit: Advancing Science for Single Ventricle Patients: From Discovery to Clinical Applications.

Reddy S, Handler SS, Wu S, Rabinovitch M, Wright G. J Am Heart Assoc. 2020 Apr 7;9(7):e015871. doi: 10.1161/JAHA.119.015871. Epub 2020 Mar 19.PMID: 32188306

Delineating the molecular and histological events that govern right ventricular recovery using a novel mouse model of pulmonary artery de-banding.

Boehm M, Tian X, Mao Y, Ichimura K, Dufva MJ, Ali K, Dannewitz Prosseda S, Shi Y, Kuramoto K, Reddy S, Kheyfets VO, Metzger RJ, Spiekerkoetter E. Cardiovasc Res. 2020 Aug 1;116(10):1700-1709. doi: 10.1093/cvr/cvz310.PMID: 31738411

Right ventricular failure in congenital heart disease.

Friedberg MK, Reddy S. Curr Opin Pediatr. 2019 Oct;31(5):604-610. doi: 10.1097/MOP.0000000000000804.PMID: 31356354

Loss of Endothelium-Derived Wnt5a Is Associated With Reduced Pericyte Recruitment and Small Vessel Loss in Pulmonary Arterial Hypertension.

Yuan K, Shamskhou EA, Orcholski ME, Nathan A, Reddy S, Honda H, Mani V, Zeng Y, Ozen MO, Wang L, Demirci U, Tian W, Nicolls MR, de Jesus Perez VA. Circulation. 2019 Apr 2;139(14):1710-1724. doi: 10.1161/CIRCULATIONAHA.118.037642.PMID: 30586764

MicroRNA-34a-Dependent Attenuation of Angiogenesis in Right Ventricular Failure.

Reddy S, Hu DQ, Zhao M, Ichimura S, Barnes EA, Cornfield DN, Alejandre Alcázar MA, Spiekerkoetter E, Fajardo G, Bernstein D. J Am Heart Assoc. 2024 Feb 6;13(3):e029427. doi: 10.1161/JAHA.123.029427. Epub 2024 Jan 31.PMID: 38293915