Sheng-Yao Dai, Ph.D.

Sheng-Yao did his Ph.D. with Prof Dan Yang. During this, he developed a photoactivatable small-molecule fluorescent probe for covalent labeling of proteins, which also demonstrated that this method allows visualization of endogenous proteins in living cells. He was also involved in the development of novel synthetic ion transporters for killing cancer stem cells and mechanistic exploration of ROS species generation from drug-like small molecules.

Education details (BS to Ph.D.)

BS: Chemistry, The University of Hong Kong, Hong Kong

MPhil: Organic Chemistry, The University of Manchester, UK

Ph.D.: Chemical Biology, The University of Hong Kong, Hong Kong

List of publications

1. Dai S. -Y.; Yang, D.*, A Visible and Near-Infrared Light Activatable Diazo-Coumarin Probe for Fluorogenic Protein Labeling in Living Cells. J. Am. Chem. Soc. 2020, 142, 17156-17166. Preprint: ChemRxiv DOI:10.26434/chemrxiv.12725666.v1.

2. Shen, F. -F.; Dai S. -Y.; Wong, N. K.; Deng, S.; Wong, A. S. -T.; Yang, D.*, Mediating K+/H+ Transport to Eradicate Cancer Stem Cells by Synthetic Cation Transporters. J. Am. Chem. Soc. 2020, 142, 10769-10779.

3. Li, M. D.; Wong, N. K.; Xiao, J.; Zhu, R.; Wu, L.; Dai, S. -Y.; Chen, F.; Huang, G.; Xu, L.; Bai, X.; Geraskina, M. R.; Winter, A. H.; Chen, X.; Liu, Y.; Fang, W.; Yang, D.; Phillips, D. L.*, Dynamics of Oxygen-Independent Photocleavage of Blebbistatin as a One-Photon Blue or Two-Photon Near-Infrared Light-Gated Hydroxyl Radical Photocage. J. Am. Chem. Soc. 2018, 140, 15957-15968.

4. Dai, S. -Y.; Yang, D.*, Visible Light and Infrared Light Fluorogenic Photoaffinity Labeling Agents and Methods Thereof. U.S. Pat. Appl. No. 62/479,476. March 2017.

5. Levick, M. T.; Grace, I.; Dai, S. Y.; Kasch, N.; Muryn, C.; Lambert, C.; Turner, M. L.; Procter, D.* J., A Sm(II)-mediated Cascade Approach to Dibenzoindolo[3,2-b]carbazoles: Synthesis and Evaluation. Org. Lett. 2014, 16, 2292-2295.

6. Rumer, J. W.*; Levick, M.; Dai, S. Y.; Rossbauer, S.; Huang, Z.; Biniek, L.; Anthopoulos, T. D.; Durrant, J. R.; Procter, D. J.; McCulloch, I., BPTs: Thiophene-flanked Benzodipyrrolidone Conjugated Polymers for Ambipolar Organic Transistors. Chem. Commun. 2013, 49, 4465-4467.

7. Rumer, J. W.*; Dai, S.-Y.; Levick, M.; Kim, Y.; Madec, M.-B.; Ashraf, R. S.; Huang, Z.; Rossbauer, S.; Schroeder, B.; Biniek, L.; Watkins, S. E.; Anthopoulos, T. D.; Janssen, R. A. J.; Durrant, J. R.; Procter, D. J.; McCulloch, I.,

8. Dihydropyrroloindoledione-based Copolymers for Organic Electronics. J. Mat. Chem. C 2013, 1, 2711-2716.

Rumer, J. W.*; Dai, S.-Y.; Levick, M.; Biniek, L.; Procter, D. J.; McCulloch, I., Synthesis of Two Dihydropyrroloindoledione-based Copolymers for Organic Electronics. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 1285-1291.