M. T. Jeena, Ph.D.

Jeena received her PhD from UNIST, Republic of Korea. Her PhD research introduced a novel strategy called organelle localization induced self-assembly of amphiphilic peptide/ small molecules for the therapeutic applications. Exploring the chemistry of small molecules inside the live cell for imaging and therapy is her major research interest.   

Education details (BS to PhD)


Thesis: Organelle localization induced self-assembly of peptide amphiphilic (OLISA) to control the cellular fate.

Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.

M.S. Applied Chemistry

Department of Applied Chemistry, Cochin University of Science and Technology, Kerala, India.

B.S. Chemistry 

Department of Chemistry, Payanur collage, Kerala, India.


1) Jeena, M. T.; Jeong, K.; Cho, Y.; Jin, S.; Kim, C.; Lee, J. H.; Lee, S.; Hwang, S. W.; Kwak, S. K.; Kim, S.; Ryu, J. H. “Drug-free supramolecular therapy” (Under revision)  

2) Jeena, M. T.; Lee, S.; Barui, A. K.; Jin, S.; Park, S. A.; Min, S. K.; Kim, C.; Ryu, J. H*. “Intra-Mitochondrial self-assembly to overcome the intracellular enzymatic degradation of L-peptides.” Chem. Commun 2020, 56, 6265-6268.

3) Jeena, M. T.; Kim, S.; Jin, S.; Ryu, J. –H*. “Recent progress of mitochondria-targeted drug and drug-free agents for cancer therapy.” Cancers, 2020, 12, 4 (Invited review).   

4) Jeena, M. T.; Jeong, K.; Go, E. M.; Cho, Y.; Lee, S.; Jin, S.; Hwang, S, -W.; Jang, J. H.; Kang, C. S.; Bang, W, -Y.; Lee, E.; Kwak, S. K.; Kim, S, Ryu, J. –H*.“Heterochiral assembly of amphiphilic peptides inside the mitochondria for supramolecular cancer therapeutics.” ACS Nano 2019, 13, 11022-11033.

5) Jeena, M. T.; Choi, H, Y.; Ryu, J. –H.“Chapter 2: Bioactive supramolecular assembly of peptide amphiphiles to control cellular fate.” Soft Nanomaterials, 2019, 27-65. (Book Chapter).

6) Jeena, M. T.; Palanikumar, L.; Go, E. M.; Kim, I.; Kang, M. G.; Lee, S.; Park, S.; Choi, H.; Kim, C.; Jin, S.-M.; Bae, S. C.; Rhee, H. W.; Lee, E.; Kwak, S. K.; Ryu, J.-H*. Mitochondria Localization Induced Self-Assembly of Peptide Amphiphiles for Cellular Dysfunction. Nat. Commun. 2017, 8, 26.

7) Jeena, M. T.; Bok, T.; Kim, S. H.; Park, S.; Kim, J.-U.; Park, S.*, Ryu, J.-H.*  “Siloxane incorporated copolymer as an in situ cross-linkable binder for high performance silicon anode in Li-ion battery" Nanoscale  2016, 8, 9245-9253.

8) Jeena, M. T.; Lee, J.-I; Kim, S. H.; Kim, C.; Kim, J.-Y.; Park, S.*; Ryu, J.-H.* “Multifunctional Molecular Design as an Efficient Polymeric Binder for Silicon Anodes in Lithium-Ion Batteries” ACS Appl. Mater.  Interfaces 20146, 18001–18007.

10) Palanikumar, L.; Jeena, M. T.; Kim, C.; Ryu, J.-H.* “Hydrophobic/Hydrophilic Dual-Drug Delivery from Noncovalent Polymer Gatekeeper in Hollow Mesoporous Silica Nanoparticle with pH-activated Charge Conversion for Enhanced Tumor Cellular Uptake ". Scientific Reports, 2017, 7, 46540.

11) Choi, H.; Jeena, M.T.; Palanikumar, L.; Jeong, Y.; Park, S.; Lee, E.*; Ryu, J.-H.* "HA-incorporated nanostructure of peptide-drug amphiphile for targeted anticancer drug delivery" Chem. Commun. 2016, 52, 5637-5640. 

12) Jin, S., Jeena, M. T., Jana, B., Moon, M., Choi, H., Lee, E., Ryu, J.-H. "Spatiotemporal Self-Assembling Peptides Dictates Cancer-Selective ToxicityBiomacromolecules 2020, accepted.

13. Kim, D. J.; Jeena, M. T.; Kim, O. H.; Hong, H. E.; Seo, H.; Ryu, J.-H.; Kim, S.-J. "Novel Therapeutic Application of Self-Assembly Peptides Targeting the Mitochondria in In Vitro and In Vivo Experimental Models of Gastric CancerInt. J. Mol. Sci.  202021, 6126

14. Park, H.; Choi, Y.; Jeena, M. T.; Ahn, E.; Choi, Y.; Kang, M, -G.; Lee, C. G.; Kwon, T, -H.; Rhee, H. –W, Ryu, J. –H, Kim, B. –S. “Reduction-Triggered Self-Cross-Linked Hyperbranched Polyglycerol Nanogel for Intracellular Delivery of Drugs and Proteins. Macromol. Biosci. 2018, 1700356.

15. Thomas, A. P.; Palanikumar, L.; Jeena, M. T.; Kim, K.; Ryu, J.-H.* "Cancer Mitochondria-Targeted Photodynamic Therapy with Supramolecular Assembly of HA and Near IR Cyanine Dye" Chem. Sci. 20178, 8351.

16. Kim, S.; Palanikumar, L.; Choi, H.; Jeena, M. T.; Kim, C*. Ryu, J. –H* "Intra-Mitochondrial Bio mineralization for Inducing Apoptosis of Cancer Cells" Chem. Sci. 2018, 9, 2474-2479.

17. Palanikumar, L.; Kim, H. Y.; Oh, J. Y.; Thomas, A. P.; Choi, E. S.; Jeena, M. T.; Joo, S. H.; Ryu, J. –H*. Noncovalent Surface Locking of Mesoporous Silica Nanoparticles for Exceptionally High Hydrophobic Drug Loading and Enhanced Colloidal Stability. Biomacromolecules 2015, 16, 2701-2714.  


Ryu, J. –H.; Jeena, M. T. Conjugate including peptide molecule capable of self-assembly in cell organelle and pharmaceutical composition for preventing or treating cancer including conjugate. US20180133330A1. (US Patent).