Peer Reviewed Journal Articles

1.       Fu J, Yang Z, Melemenidis S, Viswanathan V, Dutt S, Manjappa R, Lau B, Soto LA, Ashraf MR, Skinner L, Yu SJ, Surucu M, Casey KM, Rankin EB, Graves E, Lu W, Loo BW, Gu X. Exploring deep learning for estimating the isoeffective dose of FLASH irradiation from mouse intestinal histological images. Int J Radiat Oncol Biol Phys. 2024 Jan 1:S0360-3016(23)-08306-2. Doi: 10.1016/j.ijrobp.2023.12.032. PMID: 38171387    * Material support and drafting/revision of manuscript.

2.       Li AM, He B, Karagiannis D, Li Y, Jiang H, Srinivasan P, Ramirez Y, Zhou MN, Curtis C, Gruber JJ, Lu C, Rankin EB, Ye J. Serine starvation silences estrogen receptor signaling through histone hypoacetylation. PNAS. 2023 Sep 19;120(38):e2302489120. doi: 10.1073/pnas.2302489120. Epub 2023 Sep 11. PMID: 37695911   * Analysis and interpretation of data, material support and drafting/revision of manuscript.

3.       Klett KC, Martin-Villa BC, Villarreal VS, Melemenidis S, Viswanathan V, Manjappa R, Ashraf MR, Soto L, Lau B, Dutt S, Rankin EB, Loo BW, Heilshorn SC. Human enteroids as a tool to study conventional and ultra-high dose rate radiation. Integr Biol (Camb). 2023 Apr 11:15. doi: 10.1093/intbio/zyad013. PMID: 37874173                         * Conception and design and drafting/revision of manuscript.

4.       Jiang H, Greathouse RL, Tiche SJ, Zhao M, He B, Li Y, Li AM, Forgo B, Yip M, Li A, Shih M, Banuelos S, Zhou MN, Gruber JJ, Rankin EB, Hu Z, Shimada H, Chiu B, Ye J. Mitochondrial uncoupling induces epigenome remodeling and promotes differentiation in neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029. PMID: 36318118. * Analysis and interpretation of data, material support and drafting/revision of manuscript.

5.       Kimura T, Panaroni C, Rankin EB, Purton LE, Wu JY. Loss of parathyroid hormone receptor signaling in osteoprogenitors is associated with accumulation of multiple hematopoietic lineages in the bone marrow. J Bone Miner Res. 2022 July. doi: 10.1002/jbmr.4568. PMID: 35490308  * Conception and design, data analysis and drafting/revision of manuscript.

6.       Eggold JT, Chow S, Melemenidis S, Wang J, Natarajan S, Loo PE, Manjappa R, Viswanathan V, Kidd EA, Engleman E, Dorigo O, Loo BW, Rankin EB. Abdominopelvic FLASH irradiation improves PD-1 immune checkpoint inhibition in preclinical models of ovarian cancer. Mol Cancer Ther. 2022 Feb;21(2):371-381. doi: 10.1158/1535-7163.MCT-21-0358. PMID: 34866044

7.       Mullen MM, Lomonosova E, Toboni MD, Oplt A, Cybulla E, Blachut B, Zhao P, Noia H, Wilke D, Rankin EB, Kuroki LM, Hagemann AR, Hagemann IS, McCourt CK, Thaker PH, Mutch DG, Powell MA, Mosammaparast N, Vindigni A, Fuh KC. GAS6/AXL inhibition enhances ovarian cancer sensitivity to chemotherapy and PARP inhibition through increased DNA damage and enhanced replication stress. Mol Cancer Res. 2022 Feb;20(2):265-279. doi: 10.1158/1541-7786.MCR-21-0302. PMID: 34670865                 * Conception and design, resources and drafting/revision of manuscript.

8.       Qian J, LeSavage BL, Hubka KM, Ma C, Natarajan S, Eggold JT, Xiao Y, Fuh KC, Krishnan V, Enejder A, Heilshorn SC, Dorigo O, Rankin EB. Cancer associated-mesothelial cells promote ovarian cancer chemoresistance through paracrine osteopontin signaling. J Clin Invest. 2021 Aug 16;131(16):e146186. doi: 10.1172/JCI146186. PMID: 34396988 

9.       Mehibel M, Xu Y, Li CG, Moon EJ, Thakkar KN, Diep AN, Kim RK, Bloomstein JD, Xiao Y, Bacal J, Saldivar JC, Le QT, Cimprich KA, Rankin EB, Giaccia AJ. Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models. J Clin Invest. 2021 Jun 1;131(11):146256. doi: 10.1172/JCI146256. PMID: 34060485  * Conception and design of manuscript.

10.    Miao YR, Thakkar KN, Qian J, Kariolis MS, Huang W, Nandagopal S, Yang TTC, Diep AN, Cherf GM, Xu Y, Moon EJ, Xiao Y, Alemany H, Li T, Yu W, Wei B, Rankin EB, Giaccia AJ. Neutralization of PD-L2 is essential for overcoming immune checkpoint blockade resistance in ovarian cancer. Clin Cancer Res. 2021 May 19:clincanres.0482.2020. doi: 10.1158/1078-0432.CCR-20-0482. PMID: 34011561  * Analysis and interpretation of data and material support.

11.    Levy K, Natarajan S, Wang J, Chow S, Eggold J, Loo P, Manjappa R, Lartey FM, Schüler E, Skinner L, Rafat M, Ko R, Kim A, Rawi DA, Eyben RV, Dorigo O, Casey KM, Graves EE, Bush K, Yu AS, Koong AC, Maxim PG, Loo BW, Rankin EB. Abdominal FLASH irradiation reduces radiation-induced gastrointestinal toxicity for the treatment of ovarian cancer in mice. Sci Rep. 2020 Dec 10;10(1):21600. doi: 10.1038/s41598-020-78017-7.

12.    Ko RB, Soto LA, von Eyben R, Melemenidis S, Rankin EB, Maxim PG, Graves EE, Loo BW. Evaluating the reproducibility of mouse anatomy under rotation in a custom immobilization device for conformal FLASH radiotherapy. Radiat Res. 2020 Dec 1;194(6):600-606. doi: 10.1667/RADE-20-00095. PMID: 32857849  * Supervision and critical revision of the manuscript.

13.    Krishnan V, Tallapragada S, Schaar B, Kamat K, Chanana AM, Zhang Y, Patel S, Parkash V, Rinker-Schaeffer C, Folkins AK, Rankin EB, Dorigo O. Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1. Commun Biol. 2020 Sep 22;3(1):524. doi: 10.1038/s42003-020-01246-z. PMID: 32963283  * Supervision and critical revision of the manuscript.

14.    Xiao Y, Thakkar KN, Zhao H, Broughton J, Li Y, Seoane JA, Diep AN, Metzner TJ, von Eyben R, Dill DL, Brooks JD, Curtis C, Leppert JT, Ye J, Peehl DM, Giaccia AJ, Sinha S, Rankin EB. The m⁶A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor.  Proc Natl Acad Sci U S A. 2020 Aug 19:202000516. doi: 10.1073/pnas.2000516117. PMID: 32817424

15.    Bloomstein JD, von Eyben R, Chan A, Rankin EB, Fregoso DR, Wang-Chiang J, Lee L, Xie LX, David SM, Stehr H, Esfahani MS, Giaccia AJ, Kidd EA. Validated limited gene predictor for cervical cancer lymph node metastases. Oncotarget. 2020 Jun 16;11(24):2302-2309. doi: 10.18632/oncotarget.27632.  * Acquisition of data and supervision.

16.    Aguilera TA, Elghonaimy EA, Shehade H, Rafat M, Castellini L, Jiang D, Kariolis M, Koong AC, Le QT, Ellies LG, Rankin EB, Graves EE, Giaccia AJ. Induced tumor heterogeneity reveals factors informing radiation and immunotherapy combinations. Clin Cancer Res. 2020 Jun 15;26(12):2972-2985. doi: 10.1158/1078-0432.CCR-19-4220. Epub 2020 Feb 25. PMID: 32098769  * Acquisition of data.

17.    Li AM, Ducker GS, Li Y, Seoane JA, Xiao Y, Melemenidis S, Zhou Y, Liu L, Vanharanta S, Graves EE, Rankin EB, Curtis C, Massagué J, Rabinowitz JD, Thompson CB, Ye J. Metabolic profiling reveals a dependency of human metastatic breast cancer on mitochondrial serine and one-carbon unit metabolism. Mol Cancer Res. 2020 Apr;18(4):599-611. doi: 10.1158/1541-7786.MCR-19-0606. Epub 2020 Jan 15. PMID: 31941752  * Conception, design and acquisition of data.

18.    Xiao Y, Zhao H, Tian L, Nolley R, Diep AN, Ernst A, Fuh KC, Miao YR, von Eyben R, Leppert JT, Brooks JD, Peehl DM, Giaccia AJ, Rankin EB. S100A10 is a critical mediator of GAS6/AXL-induced angiogenesis in renal cell carcinoma. Cancer Res. 2019 Nov 15;79(22):5758-5768. doi: 10.1158/0008-5472.CAN-19-1366. PMID: 31585940

19.    Natarajan S, Foreman KM, Soriano MI, Rossen NS, Shehade H, Fregoso DR, Eggold JT, Krishnan V, Dorigo O, Krieg AJ, Heilshorn SC, Sinha S, Fuh KC, Rankin EB. Collagen remodeling in the hypoxic tumor-mesothelial niche promotes ovarian cancer metastasis. Cancer Res. 2019 May 1;79(9):2271-2284 doi: 10.1158/0008-5472.CAN-18-2616 PMID: 30862717

20.    Wu PH, Onodera Y, Ichikawa Y, Rankin EB, Giaccia AJ, Watanabe Y, Qian W, Hashimoto T, Shirato H, Nam JM. Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells. Int J Nanomedicine. 2017 Jul 14; 12:5069-5085 doi: 10.2147/IJN.S137833 PMCID: PMC5560413

21.    Sinha S, Thomas D, Chan S, Gao Y, Brunen D, Torabi D, Reinisch A, Hernandez D, Chan A, Rankin EB, Bernards R, Majeti R, Dill DL. Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data. Nat Commun. 2017 May 31; 8:15580 doi: 10.1038/ncomms15580 PMCID: PMC5460027

22.    Kariolis MS, Miao YR, Diep A, Nash SE, Olcina MM, Jiang D, Jones DS 2^nd, Kapur S, Mathews II, Koong AC, Rankin EB, Cochran JR, Giaccia AJ. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest. 2017 Jan 3;127(1):183-198. doi: 10.1172/JCI85610 PMCID: PMC5199716

23.    Aguilera TA, Rafat M, Castellini L, Shehade H, Kariolis MS, Hui AB, Stehr H, von Eyben R, Jiang D, Ellies LG, Koong AC, Diehn M, Rankin EB, Graves EE, Giacca AJ. Reprogramming the immunological microenvironment through radiation and targeting Axl. Nat Commun. 2016 Dec 23;7:13898. doi: 10.1038/ncomms13898 PMCID: PMC5196438

24.    Divine LM, Nguyen MR, Meller E, Desai RA, Arif B, Rankin EB, Bligard KH, Meyerson C,Hagemann IS, Massad M, Thaker PH, Hagemann AR, McCourt CK, Powell MA, Mutch DG, Fuh KC. AXL modulates extracellular matrix protein expression and is essential for invasion and metastasis in endometrial cancer. Oncotarget. 2016 Nov 22;7(47):77291-77305. doi: 10.18632/oncotarget.12637 PMCID: PMC5340229

25.    Zhao H, Nolley R, Chan AM, Rankin EB, Peehl DM. Cabozantinib inhibits tumor growth and metastasis of a patient-derived xenograft model of papillary renal cell carcinoma with MET mutation. Cancer Biol Ther. 2017 Nov 2;18(11):863-871. doi: 10.1080/15384047.2016.1219816 PMCID: PMC5710673

26.    Mirzamohammadi F, Papaioannou G, Inloes JB, Rankin EB, Xie H, Schipani E, Orkin SH, Kobayashi T. Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signaling. Nat Commun. 2016 Jun 22;7:12047. doi: 10.1038/ncomms12047 PMCID: PMC4917962

27.    Zhou L, Liu XD, Sun M, Zhang X, German P, Bai S, Ding Z, Tannir N, Wood CG, Matin SF, Karam JA, Tamboli P, Sircar K, Rao P, Rankin EB, Laird DA, Hoang AG, Walker CL, Giaccia AJ, Jonasch E. Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma. Oncogene. 2016 May;35(21):2687-97. doi: 10.1038/onc.2015.343 PMCID: PMC4791213

28.    Wu C, Rankin EB, Castellini L, Fernandez-Alcudia J, LaGory EL, Andersen R, Rhodes SD, Wilson TL, Mohammad KS, Castillo AB, Guise TA, Schipani E, Giaccia AJ. Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin. Genes Dev. 2015 Apr 15;29(8):817-31. doi: 101101/gad.255000.114 PMCID: PMC4403258

29.    Finger EC, Castellini L, Rankin EB, Vilalta M, Krieg AJ, Jiang D, Banh A, Zundel W, Powell MB, Giaccia AJ. Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells. Proc Natl Acad Sci USA. 2015 Apr 7;112(14):4441-6. doi: 10.1073/pnas.1418164112 PMCID: PMC4394282

30.    Rankin EB, Fuh KC, Castellini L, Viswanathan K, Finger EC, Diep A, LaGory EL, Kariolis MS, Chan A, Lindgren D, Axelson H, Miao YR, Krieg AJ, Giaccia AJ.  Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET. Proc Natl Acad Sci USA. 2014 Sep 16;111(37):13373-8. doi: 10.1073/pnas.1404848111 PMCID: PMC4169907

31.    Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O’Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E.  Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development.  Dev Biol. 2014 Sep 1;393(1):124-36. doi: 10.1016/j.ydbio.2014.06 PMCID: PMC4335807

32.    Taniguchi CM, Miao YR, Diep AN, Wu C, Rankin EB, Atwood TF Xing L, Giaccia AJ.  PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2. Sci Transl Med. 2014 May 14;6(236):236ra64. doi: 10.1126/scitranslmed.3008523 PMCID: PMC4136475

33.    Finger EC, Cheng CF, Williams TR, Rankin EB, Bedogni B, Tachiki L, Spong S, Giaccia AJ, Powell MB. CTGF is a therapeutic target for metastatic melanoma.  Oncogene. 2014 Feb 27;33(9):1093-100. doi: 10.1038/onc.2013.47 PMCID: PMC3965577

34.    Rankin EB*, Wu C*, Khatri R, Wilson TL, Anderson R, Araldi E, Rankin AL, Yuan J, Kuo CJ, Schipani E, Giaccia AJ. The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Cell. 2012 Mar 30;149(1):63-74. doi: 10.1016/j.cell.2012.01.051 PMCID: PMC3408231. * co-first author

35.    Rankin EB, Fuh KC, Taylor TE, Krieg AJ, Musser M, Yuan J, Wei K, Kuo CJ, Longacre TA, Giaccia AJ.  AXL is an essential factor and therapeutic target for metastatic ovarian cancer. Cancer Res. 2010 Oct 1;70(19):7570-9. doi: 10.1158/0008-5472.CAN-10-1267 PMCID: PMC3408227

36.    Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ.  Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol. 2010 Jan;30(1):344-53. doi: 10.1128/MCB.00444-09 PMCID: PMC2798291

37.    Rankin EB, Rha J, Selak MA, Unger TL, Keith B, Liu Q and Haase VH.  Hypoxia-inducible factor 2 regulates hepatic lipid metabolism. Mol Cell Biol. 2009 Aug;29(16):4527-38. doi: 10.1128/MCB.00200-09 PMCID: PMC2725738

38.    Kimura K, Iwano M, Higgins DF, Yamaguchi Y, Nakatani K, Harada K, Kubo A, Akai Y, Rankin EB, Neilson EG, Haase VH, Saito Y. Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis. Am J Physiol Renal Physiol. 2008 Oct;295(4): F1023-9. doi: 10.1152/ajprenal.90209.2008 PMCID: PMC4250235

39.    Rankin EB, Rha J, Unger TL, Wu CH, Shutt HP, Johnson RS, Simon MC, Keith B and Haase VH. Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene. 2008 Sep11;27(40):5354-8. doi: 10.1038/onc.2008.160 PMCID: PMC2575082

40.    Rankin EB, Biju MP, Liu Q, Rha J, Johnson RS, Simon CM, Keith B and Haase VH.   Hypoxia inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest. 2007 Apr;117(4):1068-77 PMCID: PMC1838939

41.    Rankin EB, Tomaszewski JE and Haase VH.    Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor. Cancer Res. 2006 Mar 1;66(5):2576-2583 PMCID: PMC3514875

42.    Rankin EB, Higgins DF, Walisser JA, Johnson RS, Bradfield CA and Haase VH. Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol. 2005 Apr;25(8):3163-72 PMCID: PMC1069599

43.    Rankin EB, Xu W, Silberg DG and Suh E. Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine. Am J Physiol Gastrointest Liver Physiol. 2004 May;286(5):G872-80. doi: 10.1152/ajpgi.00326.2003 PMID: 14715525

44.    Rankin EB, Yu D, Jiang J, Shen H, Pearce EJ, Goldschmidt MH, Levy DE, Golovkina TV, Hunter CA and Thomas-Tikhonenko A. An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth. Cancer Biol Ther. 2003 Nov-Dec;2(6):687-93. PMID: 14688478

45.    Suh ER, Ha CS, Rankin EB, Toyota M and Traber PG. DNA methylation down regulates CDX1 gene expression in colorectal cancer cell lines. J Biol Chem. 2002 Sep 27;277(39):35795-800. doi: 10.1074/jbc.M205567200. PMID: 1212493

Peer –Reviewed Review Articles

1.       Miao YR, Rankin EB, Giaccia AJ. Therapeutic targeting of the functionally elusive TAM receptor family. Nat Rev Drug Discov. 2023 Dec13. doi: 10.1038/s41573-023-00846-8. PMID: 38092952  * Drafting and critical revision of the manuscript.

2.       Zhang D, Wornow S, Peehl DM, Rankin EB, Brooks JD. The controversial role and therapeutic development of the m6A demethylase FTO in renal cell carcinoma. Transl Oncol. 2022 Nov;25:101518. doi: 10.1016/j.tranon.2022.101518. Epub 2022 Aug 27. PMID: 36037557  * Drafting and critical revision of the manuscript.

3.       Qian J and Rankin EB. Hypoxia-induced phenotypes that mediate tumor heterogeneity. Adv Exp Med Biol. 2019;1136:43-55. doi: 10.1007/978-3-030-12734-3_3. PubMed PMID: 31201715.

4.       Eggold JT and Rankin EB. Erythropoiesis, EPO, macrophages, and bone. Bone. 2019 Feb;119:36-41. doi: 10.1016/j.bone.2018.03.014 PMCID: PMC 6139082

5.       Rankin EB. Genomics and molecular mechanisms of high grade serous ovarian cancer: the 12th Biennial Rivkin Center Ovarian Cancer Research Symposium. Int J Gynecol Cancer. 2019 Aug;29(Suppl 2):s7-s11. doi: 10.1136/ijgc-2019-000490.PMID: 31462542

6.       Rankin EB and Giaccia AJ. The receptor tyrosine kinase AXL in cancer progression. Cancers (Basel). 2016 Nov 9;8(11). PMID: PMC5126763

7.       Rankin EB, Nam JM, and Giaccia AJ. Hypoxia: Signaling in the metastatic cascade. Trends in Cancer. 2016 Jun 2;(6):295–304. doi: 10.1016/j.trecan.2016.05.006 PMCID: PMC5808868

8.       Rankin EB and Giaccia AJ. Hypoxic control of metastasis. Science. 2016 Apr 8;352(6282):175-80. doi:10.1126/science.aaf4405 PMCID: PMC4898055

9.       Rankin EB, Narla A, Park JK, Lin S and Sakamoto KM.  Biology of the bone marrow microenvironment and myelodysplastic syndromes. Mol Genet Metab. 2015 Sep-Oct; 116(1-2):24-8. doi: 10.1016/j.ymgme.2015.07.004 PMCID: PMC4618471

10.    Wu C, Giaccia AJ, and Rankin EB. Osteoblasts: A novel source of erythropoietin. Curr Osteoporos Rep. 2014 Dec;12(4):428-32. doi: 10.1007/s11914-014-0236-x PMCID: PMC4349388

11.    Schipani E, Wu C, Rankin EB, and Giaccia AJ. Regulation of bone marrow angiogenesis by osteoblasts during bone development and homeostasis. Front Endocrinol (Lausanne) 2013 Jul 10;4:85. doi: 10.3389/fendo.2013.00085 PMCID: PMC3706978

12.    Wu C, Rankin EB, and Giaccia AJ. Blood and bones: Osteoblastic HIF signaling regulates erythropoiesis. Cell Cycle 2012 Jun 15;11(12)2221-2. doi: 10.4161/cc.20635 PMCID: PMC3383578

13.    Rankin EB, Giaccia AJ and Schipani E.  A central role for hypoxia signaling in cartilage, bone, and hematopoiesis.  Curr Osteoporosis Rep. 2011 Jun;9(2):46-52. doi: 10.007/s11914-011-0047-2 PMCID: PMC40125

14.    Rankin EB, Giaccia AJ and Hammond EM.  Bringing H2AX into the angiogenesis family. Cancer Cell. 2009 Jun 2;15(6):459-61. doi: 10.1016/j.ccr.2009.05.004 PMCID: PMC3408225

15.    Rankin EB and Giaccia AJ. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ. 2008 Apr;15(4):678-85. doi: 10.1038/cdd.2008.21 PMCID: PMC 3050610