Publications

Peer Reviewed Journal Articles

1. Wu PH, Onodera Y, Ichikawa Y, Rankin EB, Giaccia AJ, Watanabe Y, Qian W, Hashimoto T, Shirato H, Nam JM. Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells. Int J Nanomedicine. 2017 Jul 14;12:5069-5085.

2. Sinha S, Thomas D, Chan S, Gao Y, Brunen D, Torabi D, Reinisch A, Hernandez D, Chan A, Rankin EB, Bernards R, Majeti R, Dill DL. Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data. Nat Commun. 2017 May 31;8:15580

3. Kariolis MS, Miao YR, Diep A, Nash SE, Olcina MM, Jiang D, Jones DS 2nd, Kapur S, Math II, Koong AC, Rankin EB, Cochran JR, Giaccia AJ. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest. 2017 Jan 3;127(1):183-198. doi: 10.1172/JCI85610. (PMCID: PMC5199716)

4. Aguilera TA, Rafat M, Castellini L, Shehade H, Kariolis MS, Hui AB, Stehr H, von Eyben R, Jiang D, Ellies LG, Koong AC, Diehn M, Rankin EB, Graves EE, Giacca AJ. Reprogramming the immunological microenvironment through radiation and targeting Axl. Nat Commun. 2016 Dec 23;7:13898. doi: 10.1038/ncomms13898. (PMCID: PMC5196438)

5. Divine LM, Nguyen MR, Meller E, Desai RA, Arif B, Rankin EB, Bligard KH, Meyerson C,Hagemann IS, Massad M, Thaker PH, Hagemann AR, McCourt CK, Powell MA, Mutch DG, Fuh KC. AXL modulates extracellular matrix protein expression and is essential for invasion and metastasis in endometrial cancer. Oncotarget. 2016 Nov 22;7(47):77291-77305. doi: 10.18632/oncotarget.12637. (PMID: 27764792)

6. Zhao H, Nolley R, Chan AM, Rankin EB, Peehl DM. Cabozantinib inhibits tumor growth and metastasis of a patient-derived xenograft model of papillary renal cell carcinoma with MET mutation. Cancer Biol Ther. 2016 Aug 11:0. doi: 10.1080/15384047.2016.1219816. [Epub ahead of print] (PMID: 27715452)

7. Mirzamohammadi F, Papaioannou G, Inloes JB, Rankin EB, Xie H, Schipani E, Orkin SH, Kobayashi T. Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signaling. Nat Commun. 2016 Jun 22;7:12047. doi: 10.1038/ncomms12047. (PMCID: PMC4917962)

8. Zhou L, Liu XD, Sun M, Zhang X, German P, Bai S, Ding Z, Tannir N, Wood CG, Matin SF, Karam JA, Tamboli P, Sircar K, Rao P, Rankin EB, Laird DA, Hoang AG, Walker CL, Giaccia AJ, Jonasch E. Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma. Oncogene. 2016 May,35(21):2687-97. doi: 10.1038/onc.2015.343. Epub 2015 Sep 14. (PMCID: PMC4791213)

9. Wu C, Rankin EB, Castellini L, Fernandez-Alcudia J, LaGory EL, Andersen R, Rhodes SD, Wilson TL, Mohammad KS, Castillo AB, Guise TA, Schipani E, Giaccia AJ. Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin. Genes Dev. 2015 Apr 15;29(8):817-31. doi: 101101/gad.255000.114. Epub 2015 Apr 6. (PMCID: PMC4403258)

10. Finger EC, Castellini L, Rankin EB, Vilalta M, Krieg AJ, Jiang D, Banh A, Zundel W, Powell MB, Giaccia AJ. Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells. Proc Natl Acad Sci USA. 2015 Apr 7;112(14):4441-6. doi: 10.1073/pnas.1418164112. Epub 2015 Mar 19. (PMCID: PMC4394282)

11. Rankin E, Fuh KC, Castellini L, Viswanathan K, Finger EC, Diep A, LaGory E, Kariolis M, Chan A, Lindgren D, Axelson H, Miao Y, Krieg A, Giaccia AJ.  Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET. Proc Natl Acad Sci USA. 2014 Sep 16;111(37):13373-8. doi: 10.1073/pnas.1404848111. Epub 2014 Sep 3. (PMCID: PMC4169907)

12. Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O’Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E. Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development.  Dev Biol. 2014 Sep 1;393(1):124-36. doi: 10.1016/j.ydbio.2014.06.013. Epub 2014 Jun 24. (PMCID: PMC4335807)

13. Taniguchi CM, Miao YR, Diep AN, Wu C, Rankin EB, Atwood TF Xing L, Giaccia AJ.  PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2. Sci Transl Med. 2014 May 14;6(236):236ra64. doi: 10.1126/scitranslmed.3008523. (PMCID: PMC4136475)

14. Finger E C, Cheng C-F, Williams T R, Rankin EB, Bedogni B, Tachiki L, Spong S, Giaccia  A J, Powell M B. CTGF is a therapeutic target for metastatic melanoma.  Oncogene. 2014 Feb 27;33(9):1093-100. doi: 10.1038/onc.2013.47. Epub 2013 Feb 25. (PMCID: PMC3965577)

15. Rankin EB, Wu C, Khatri R, Wilson TLS, Araldi E, Rankin AL, Yuan J, Kuo CJ,  Schipani E, Giaccia AJ. The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Cell. 2012 Mar 30;149(1):63-74. doi: 10.1016/j.cell.2012.01.051. (PMCID: PMC3408231)

16. Rankin EB, Fuh KC, Taylor TE, Krieg AJ, Musser M, Yuan J, Wei K, Kuo CJ, Longacre TA, Giaccia AJ.  AXL is an essential factor and therapeutic target for metastatic ovarian cancer. Cancer Res. 2010 Oct 1;70(19):7570-9. doi: 10.1158/0008-5472.CAN-10-1267. Epub 2010 Sep 21. (PMID: 20858715).

17. Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ.  Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol. 2010 Jan;30(1):344-53. doi: 10.1128/MCB.00444-09. (PMCID: PMC2798291)

18. Rankin EB, Rha J, SelakMA, Unger TL, Keith B, Liu Q and Haase VH.  HIF-2 regulates hepatic lipid metabolism. Mol Cell Biol. 2009 Aug;29(16):4527-38. doi: 10.1128/MCB.00200-09. Epub 2009 Jun 15. (PMCID: PMC2725738)

19. Rankin EB, Rha J, Unger TL, Wu CH, Shutt HP, Johnson RS, Simon MC, Keith B, Haase VH. Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene. 2008 Sep11;27(40):5354-8. doi: 10.1038/onc.2008.160 Epub 2008 May 19. (PMCID: PMC2575082)

20. Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Nizet V, Johnson RS. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest. 2007 Jul;117(7):1926-32. (PMCID: PMC1884690)

21. Rankin EB, Biju MP, Liu Q, Rha J, Johnson RS, Simon CM, Keith B, Haase VH. Hypoxia inducible factor (HIF)-2 regulates hepatic EPO expression in vivo. J Clin Invest. 2007 Apr;117(4):1068-77. (PMCID: PMC1838939)

22. Rankin EB, Tomaszewski JE, Haase VH. Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor. Cancer Res. 2006 Mar;66(5):2576-2583. (PMCID: PMC3514875)

23. Rankin EB, Higgins DF, Walisser JA, Johnson RS, Bradfield CA, Haase VH. Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease associated vascular tumors in mice. Mol Cell Biol. 2005 Apr;25(8):3163-72. (PMCID: PMC1069599)

24. Rankin EB, Xu W, Silberg DG, Suh E. Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine. Am J Physiol Gastrointest Liver Physiol. 2004 May;286(5):G872-80. doi: 10.1152/ajpgi.00326.2003. Epub 2004 Jan 8. (PMID: 14715525)

25. Rankin EB, Yu D, Jiang J, Shen H, Pearce EJ, Goldschmidt MH, Levy DE, Golovkina TV, Hunter CA, Thomas-Tikhonenko A. An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth. Cancer Biol Ther. 2003 Nov-Dec;2(6):687-93. (PMID: 14688478)

26. Suh ER, Ha CS, Rankin EB, Toyota M, Traber PG. DNA methylation down regulates CDX1 gene expression in colorectal cancer cell lines. J Biol Chem. 2002 Sep 27;277(39):35795-800. doi: 10.1074/jbc.M205567200. (PMID: 1212493)

 

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