Our Team

Dr. Rabinovitch is proud to lead a team of talented individuals working together to advance cardiopulmonary research.

Lingli Wang, MD
Basic Life Research Scientist
Lab Manager

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Dr. Lingli Wang joined Dr. Rabinovitch’s group in July 2003 as lab manager, bringing over 10 years of experience in life science research to the group. Dr. Wang manages the transgenic mouse lines produced and used in the different research projects. With Dr. Cao, she trains new postdoctoral fellows and laboratory staff, and manages the day to day operations of the lab. In addition to managing the lab, Dr. Wang also investigates the cardiovascular phenotype in mice with tissue specific deletion of BMPRII. She found that loss of Bmpr2 in pulmonary artery smooth muscle cells (PASMC) causes congenital heart diseases in mice. The penetrance is about 50%, and the survivors developed pulmonary hypertension (PH) in a mouse model of reoxygenation after chronic hypoxia. She found that loss of Bmpr2 in PASMC leads to reduced contractility and heightened proliferation, caused by elevated SMAD2/3 and ARRB2 and consequent increase in pAKT mediated activation of β-Catenin and reduction in RHOA/RAC1.

Dr. Wang received her MD degree from the Fourth Army Medical University in Xi'an, China. She completed her postdoctoral studies at Stanford's Dept. of Pediatrics in 1997, where she investigated the mechanism of interferon resistance in rotavirus. Prior to Stanford, she worked at the University of Southern California, School of Medicine.  Following her postdoctoral studies, Dr. Wang worked in Stanford's Dept. of Pediatrics Hematology and Oncology Division, investigating multi-drug resistance, and found a novel inhibitor of apoptosis, ARMER; and in the Dept. of Pathology, where she investigated markers for human kidney tumors using cDNA and tissue microarrays and computer-assisted data analysis.

 


Lingli's project

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Kamakshi Dattatray Bichu
Life Science Research Professional 1

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Kamakshi earned her MS from Duke University in December 2023, where she conducted her research under the guidance of Dr. Dmitry Velmeshev. Her research focused on designing and fabricating 3D-printed scaffolds optimized for neuronal stem cell growth. Her work included differentiating iPSCs into neural stem cells and fostering organoid formation. She experimented with various bioink formulations and adhesion molecules, refining scaffold compatibility to support organoid development.

In May 2024, Kamakshi joined the Rabinovitch lab, where her research explores why some BMPR2 mutation carriers are protected from pulmonary arterial hypertension (PAH) despite carrying a mutation associated with the disease. By using metabolic labeling techniques, she aims to identify the regulatory mechanisms that may protect these unaffected carriers. Understanding these mechanisms could shed light on why similar regulatory pathways might be absent or altered in familial PAH patients, ultimately leading to disease onset.

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Yuxi Zhang
Basic Life Science Research Professional 1

 

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Yuxi Zhang joined the Rabinovitch Lab in August 2025 as a Life Science Research Professional. He is originally from Taiyuan, China, and completed his undergraduate training at the University of California, Berkeley, where he pursued a dual degree with honors in molecular biology and metabolic biology, and conducted two honors theses.

In the Rabinovitch Lab, Yuxi’s work focuses on animal models of pulmonary vascular disease. His primary responsibilities include managing transgenic mouse colonies, breeding and genotyping strategies, and supporting in vivo studies aimed at understanding the genetic and molecular mechanisms underlying pulmonary arterial hypertension (PAH).

Prior to joining Stanford, Yuxi conducted research at the Innovative Genomics Institute (IGI) at UC Berkeley in the Murthy Lab, where he worked on lipid nanoparticle engineering for therapeutic delivery. His research integrated molecular and biochemical approaches with in vitro and in vivo functional assays.

Yuxi’s research interests center on the use of animal models and molecular biology approaches to investigate disease mechanisms and support translational research in cardiovascular and pulmonary biology.

 

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Aiqin Cao, PhD
Life Science Research Professional 4

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Dr. Cao joined the Rabinovitch Laboratory in April 2011, where she manages day to day operations in the lab with Dr. Lingli Wang, supervises new fellows and performs key experiments to finalize projects for publication.  In addition to these duties, Dr. Cao investigates the mechanism of arterial and venous dysfunction in Hypoplastic Left Heart Syndrome (HLHS) using induced pluripotent stem cells (iPSCs) obtained from both healthy individuals and from HLHS patients.

Dr. Aiqin Cao received her PhD degree in Biology from Purdue University. Her graduate research in the laboratory of Dr. K.G. Raghothama focused on the molecular mechanism of plant response to phosphate (Pi) stress. Dr. Cao showed that Phosphate differentially regulates 14-3-3 family members, and GRF9 plays a role in Pi-starvation induced responses in Arabidopsis thaliana, and that a protein phosphatase gene family from tomato (LePS2;1) and from Arabidopsis thaliana (AtPS2) are induced during phosphate starvation. The studies shed a light on the adaptive response of plants to Pi deficiency that could be altered in a genetically modified plant to allow it to adapt to natural Pi stress.  For her postdoctoral studies, Dr. Cao joined Stanford’s Division of Endocrinology investigating the molecular mechanism of human oncostatin M (OM) mediated signal transductions in lipid metabolism. She identified long chain acyl-CoA synthetase-3 (ACSL3) as a molecular target for peroxisome proliferator-activated receptor delta, and, in a second project, demonstrated that the suppression of proprotein convertase subtilisin/kexin type 9 (PCSK9) expression by OM as a mechanism that increases LDLR protein in liver cells.

 

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Patricia A. del Rosario,  BSN, RN, PHN
Clinical Research Coordinator 2

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Patricia Del Rosario joined the Rabinovitch lab in May 2009. is the clinical research coordinator for the Stanford Transplant Tissue Bank, formerly part of the Pulmonary Hypertension Breakthrough Initiative (PHBI) led by Drs. Zamanian and Rabinovitch, and a research nurse for PH clinical trial studies at Stanford’s Adult PH Program. With Dr. Roof, Ms. del Rosario played a key role in the coordination and oversight of the Phase 1 clinical trial “Safety and Tolerability of Escalating Doses of Subcutaneous Elafin (Tiprelestat) Injection in Healthy Normal Subjects”, including the development of the study protocol, eCRFs, sample collection kits, obtaining and maintaining regulatory approvals.

Patricia earned a BS in Biochemistry from San Francisco State University and a BS in Nursing from Dominican University of California. Prior to working at Stanford, she worked at Exelixis, Inc. as a research associate in combinatorial chemistry and, after pursuing her nursing education, in Marin General Hospital as a labor and delivery/NICU nurse.

 

 

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