• Dysregulated Smooth Muscle Cell BMPR2 - ARRB2 Axis Causes Pulmonary Hypertension. Wang L, Moonen JR, Cao A, Isobe S, Li CG, Tojais NF, Taylor S, Marciano DP, Chen PI, Gu M, Li D, Harper RL, El-Bizri N, Kim YM, Stankunas K, Rabinovitch M. Circ Res. 2023;132:545–564 (PMCID: PMC10008520)
• KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress. Moonen JR, Chappell J, Shi M, Shinohara T, Li D, Mumbach MR, Zhang F, Nair RV, Nasser J, Mai DH, Taylor S, Wang L, Metzger RJ, Chang HY, Engreitz JM, Snyder MP, Rabinovitch M.  Nat Commun. 2022 Aug 23;13(1):4941. (PMCID: PMC9399231)
• KMT2D-Notch Mediates Coronary Abnormalities in Hypoplastic Left Heart Syndrome. Yu Z, Zhou X, Liu Z, Pastrana-Gomez V, Liu Y, Guo M, Tian L, Nelson TJ, Wang N, Mital S, Chitayat D, Wu JC, Rabinovitch M, Wu SM, Snyder MP, Miao Y, Gu M. Circ Res. 2022 Jul 22;131(3):280-282. (PMID: 35762338)
  
• Endogenous retroviral elements generate pathologic neutrophils in pulmonary arterial hypertension. Taylor S, Isobe S, Cao A, Contrepois K, Benayoun BA, Jiang L, Wang L, Melemenidis S, Ozen MO, Otsuki S, Shinohara T, Sweatt AJ, Kaplan J, Moonen JR, Marciano DP, Gu M, Miyagawa K, Hayes B, Sierra RG, Kupitz CJ, Del Rosario PA, Hsi A, Thompson AAR, Ariza ME, Demirci U, Zamanian RT, Haddad F, Nicolls MR, Snyder MP, Rabinovitch M.  Am J Resp Crit Care Med. 2022 Oct 15;206(8):1019-34. (PMID: 35696338; PMCID in progress)
• Role of endothelial cells in pulmonary fibrosis via SREBP2 activation. Martin M, Zhang J, Miao Y, He M, Kang J, Huang HY, Chou CH, Huang TS, Hong HC, Su SH, Wong SS, Harper RL, Wang L, Bhattacharjee R, Huang HD, Chen ZB, Malhotra A, Rabinovitch M, Hagood JS, Shyy JY. JCI Insight. 2021 Nov 22;6(22):e125635. doi: 10.1172/jci.insight.125635. PMID: 34806652
  

Computational simulation-derived hemodynamic and biomechanical properties of the pulmonary arterial tree early in the course of ventricular septal defects. Dong ML, Lan IS, Yang W, Rabinovitch M, Feinstein JA, Marsden AL. Biomech Model Mechanobiol. 2021 Dec;20(6):2471-89. (PMID: 34585299)

• Monocyte released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition
  Otsuki S, Saito T, Taylor S, Li D, Moonen JR, Marciano D, Harper RL, Cao A, Wang L, Ariza ME, Rabinovitch M. JCI Insight 2021 Jun 29:146416.
  
• Severe Pulmonary Arterial Hypertension is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency
  Sweatt AJ, Miyagawa K, Rhodes CJ, Taylor S, del Rosario PA, His A, Haddad F, Spiekerkoetter E, Roof MB, Bland RD, Swietlik EM, Graf S, Wilkins MR, Morrell NW, Nicolls MR, Rabinovitch M, Zamanian RT. Chest 2021 Jun 25:S0012-3692(21)01255-1.
  
• Frataxin deficiency promotes endothelial senescence in pulmonary hypertension.Frataxin deficiency promotes endothelial senescence in pulmonary hypertension
  Culley MK, Zhao J, Tai YY, Tang Y, Perk D, Negi V, Yu Q, Woodcock CC, Handen A, Speyer G, Kim S, Lai YC, Satoh T, Watson AM, Aaraj YA, Sembrat J, Rojas M, Goncharov D, Goncharova EA, Khan OF, Anderson DG, Dahlman JE, Gurkar AU, Lafyatis R, Fayyaz AU, Redfield MM, Gladwin MT, Rabinovitch M, Gu M, Bertero T, Chan SY. J Clin Invest 2021 Jun 1;131(11):136459.
• iPSC-Endothelial Cell Phenotypic Drug Screening and in Silico Analyses Identify Tryphostin-AG1296 for Pulmonary Arterial Hypertension
  Gu M, Donato M, Miao Y, Mao S, Saito T, Otsuki S, Wang L, Harper RL, Sa S, Khatri P, Rabinovitch M. Science Transl Med 2021 May 5;13(592):eaba6480.
• ALDH1A3 Coordinates Metabolism with Gene Regulation in Pulmonary Arterial Hypertension
  Li D, Shao N-Y, Moonen J-R, Zhao A, Shi M, Otsuki S, Wang L, Nguyen T, Yan E, Maricano DP, Contrepois K, Li CG, Wu JC, Snyder MP, Rabinovitch M. Circulation 2021 May 25;143(2):2074-90.
• Targeted proteomics of right heart adaptation to pulmonary arterial hypertension
  Amsallem M, Sweatt AJ, Arthur Ataam J, Guihaire J, Lecerf F, Lambert M, Ghigna MR, Ali MK, Mao Y, Fadel E, Rabinovitch M, de Jesus Perez V, Spiekerkoetter E, Mercier O, Haddad F, Zamanian RT. Eur Respir J 2021 Apr 8;57(4):2002428.
• PPARgamma-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension
  Hennigs JK, Cao A, Li CG, Shi M, Mienert J, Miyagawa K, Körbelin J, Marciano DP, Chen PI, Roughley M, Elliott MV, Harper RL, Bill MA, Chappell J, Moonen JR, Diebold I, Wang L, Snyder MP, Rabinovitch M. Circ Res 2021; Feb 5;128(3):401-18.
• Patient-Specific Induced Pluripotent Stem Cells Implicate Intrinsic Impaired Contractility in Hypoplastic Left Heart Syndrome
  Paige SL, Galdos FX, Lee S, Chin ET, Ranjbarvaziri S, Feyen DAM, Darsha AK, Xu S, Ryan JA, Beck AL, Qureshi MY, Miao Y, Gu M, Bernstein D, Nelson TJ, Mercola M, Rabinovitch M, Ashley EA, Parikh VN, Wu SM. Circulation. 2020 Oct 20;142(16):1605-08.
• Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome
  Miao Y, Tian L, Martin M, Paige SL, Galdos FX, Li J, Klein A, Zhang H, Ma N, Wei Y, Stewart M, Lee S, Moonen JR, Zhang B, Grossfeld P, Mital S, Chitayat D, Wu JC, Rabinovitch M, Nelson TJ, Nie S, Wu SM, Gu M. Cell Stem Cell. 2020 Oct 1;27(4):574-89.
• Image-based scaling laws for somatic growth and pulmonary artery morphometry from infancy to adulthood
  Dong M, Yang W, Tamaresis JS, Chan FP, Zucker EJ, Kumar S, Rabinovitch M, Marsden AL, Feinstein JA. Am J Physiol Heart Circ Physiol. 2020 Aug 1;319(2):H432-42.
• Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program
  Kanchan K, Iyer K, Yanek LR, Carcamo-Orive I, Taub MA, Malley C, Baldwin K, Becker LC, Broeckel U, Cheng L, Cowan C, D'Antonio M, Frazer KA, Quertermous T, Mostoslavsky G, Murphy G, Rabinovitch M, Rader DJ, Steinberg MH, Topol E, Yang W, Knowles JW, Jaquish CE, Ruczinski I, Mathias RA. Stem Cell Res. 2020 Jul;46:101803.
• Cellular senescence impairs the reversibility of pulmonary arterial hypertension
  van der Feen DE, Bossers GPL, Hagdorn QAJ, Moonen JR, Kurakula K, Szulcek R, Chappell J, Vallania F, Donato M, Kok K, Kohli JS, Petersen AH, van Leusden T, Demaria M, Goumans MTH, De Boer RA, Khatri P, Rabinovitch M, Berger RMF, Bartelds B. Sci Transl Med. 2020 Jul 29;12(554):eaaw4974.
• Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy
  Sayed N, Liu C, Ameen M, Himmati F, Zhang JZ, Khanamiri S, Moonen JR, Wnorowski A, Cheng L, Rhee JW, Gaddam S, Wang KC, Sallam K, Boyd JH, Woo YJ, Rabinovitch M, Wu JC. Sci Transl Med. 2020 Jul 29;12(554):eaax9276.
• Landscape of Cohesin-Mediated Chromatin Loops in the Human Genome
  Grubert F, Srivas R, Spacek DV, Kasowski M, Velasco MR, Sinnott-Armstrong N, Greenside P, Narasimha A, Liu Q, Geller B, Sanghi A, Kulik M, Sa S, Rabinovitch M, Kundaje A, Dalton S, Zaugg J, Snyder MP. Nature. 2020 Jul;583(7818):737-743. 
• PPARgamma Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis
  Li, C. G., Mahon, C., Sweeney, N. M., Verschueren, E., Kantamani, V., Li, D., Hennigs, J. K., Marciano, D. P., Diebold, I., Abu-Halawa, O., Elliott, M., Sa, S., Guo, F., Wang, L., Cao, A., Guignabert, C., Sollier, J., Nickel, N. P., Kaschwich, M., Cimprich, K. A., Rabinovitch, M. Cell Reports. 2019; 26 (5): 1333.
  
• Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension. 
  Reyes-Palomares A, Gu M, Grubert F, Berest I, Sa S, Kasowski M, Arnold C, Shuai M, Srivas R, Miao S, Li D, Snyder MP, Rabinovitch M, Zaugg JB. Nat Commun. 2020 Apr 3;11(1):1673.
• Smooth Muscle Contact Drives Endothelial Regeneration by BMPR2-Notch1 Mediated Metabolic and Epigenetic Changes
  Miyagawa, K., Shi, M., Chen, P., Hennigs, J. K., Zhao, Z., Wang, M., Li, C. G., Saito, T., Taylor, S., Sa, S., Cao, A., Wang, L., Snyder, M. P., Rabinovitch, M. Circ Res. 2019 Jan 18;124(2):211-24.
• Elafin treatment rescues EGFR-Klf4 signaling and lung cell survival in ventilated newborn mice
  Alejandre Alcazar MA, Kaschwich M, Ertsey R, Preuss S, Milla C, Mujahid S, Masumi J, Khan S, Mokres LM, Tian L, Mohr J, Hirani DV, Rabinovitch M, Bland RD. Am J Respir Cell Mol Biol. 2018 Nov;59(5):623-34.
• Right ventricular stroke work correlates with outcomes in pediatric pulmonary arterial hypertension
  Yang W, Marsden AL, Ogawa MT, Sakarovitch C, Hall KK, Rabinovitch M, Feinstein JA. Pulm Circ. 2018 Jul-Sep;8(3):2045894018780534.
• Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary Hypertension
  Tamosiuniene R, Manouvakhova O, Mesange P, Saito T, Qian J, Sanyal M, Lin YC, Nguyen LP, Luria A, Tu AB, Sante JM, Rabinovitch M, Fitzgerald DJ, Graham BB, Habtezion A, Voelkel NF, Aurelian L, Nicolls MR. Circ Res. 2018 Jun 8;122(12):1689-1702.
  
• Upregulation of Human Endogenous Retrovirus-K is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension
  Saito T, Miyagawa K, Chen SY, Tamosiuniene R, Wang L, Sharp O, Samayoa E, Harada D, Moonen JAJ, Cao A, Chen PI, Hennigs JK, Gu M, Li CG, Leib RD, Li D, Adams CM, Del Rosario PA, Bill MA, Haddad F, Montoya JG, Robinson W, Fantl WJ, Nolan GP, Zamanian RT, Nicolls MR, Chiu CY, Ariza ME, Rabinovitch M. Circulation. 2017 Nov 14;136(20):1920-1935.
• Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-β in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension
  Tojais NF, Cao A, Lai YJ, Wang L, Chen PI, Alcazar MAA, de Jesus Perez V, Hopper RK, Rhodes CJ, Bill MA, Sakai LY, Rabinovitch M. Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1559-69.
  
• Amphetamines Promote Mitochondrial Dysfunction and DNA Damage in Pulmonary Hypertension
  Chen P-I, Cao A, Miyagawa K, Tojais NF, Hennigs JK, Li CG, Sweeney NM, Inglis AS, Wang L, Li D, Ye M, Feldman BJ, and Rabinovitch M.  JCI Insight 2017, Jan 26;2(2):e90427
• iPSC Model of Pulmonary Arterial Hypertension Reveals Novel Gene Expression and Patient Specificity
  Sa S, Gu M, Chappell JC, Shao N-Y, Li D, Ameen M, Elliot K, Grubert F, Li CG, Taylor S, Cao A, Ma Y, Fong R, Nguyen L, Wu JC, Snyder MP, Rabinovitch M. Am J Respir Crit Care Med. 2017 Apr 1;195(7):930-41
• Patient-Specific iPSC Derived Endothelial Cells Uncover Pathways that Protect Against Pulmonary Hypertension in BMPR2 Mutation Carriers
  Gu M, Shao N-Y, Silin Sa S, Li D, Termglinchan V, Ameen M, Karakikes I, Sosa G, Grubert F, Lee J, Cao A, Taylor S, Ma Y, Zhao Z, Chappell J, Hamid R, Austin ED, Gold JD, Wu JC, Snyder MP,  Rabinovitch M. Cell Stem Cell. 2017 Apr 6;20(4):490-504
• In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition Via HMGA1 and its Target Slug
  Hopper RK, Moonen JA, Diebold I, Cao A, Rhodes CJ, Tojais NF, Hennigs JK, Gu M, Wang L, Rabinovitch M. Circulation. 2016 May 3;133(18):1783-94
  
• RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension
  Rhodes, C. J., Im, H., Cao, A., Hennigs, J. K., Wang, L., Sa, S., Chen, P., Nickel, N. P., Miyagawa, K., Hopper, R. K., Tojais, N. F., Li, C. G., Gu, M., Spiekerkoetter, E., Xian, Z., Chen, R., Zhao, M., Kaschwich, M., del Rosario, P. A., Bernstein, D., Zamanian, R. T., Wu, J. C., Snyder, M. P., Rabinovitch, M. Am J Respir Crit Care Med.  2015; 192 (3): 356-366
• Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling
  Nickel, N. P., Spiekerkoetter, E., Gu, M., Li, C. G., Li, H., Kaschwich, M., Diebold, I., Hennigs, J. K., Kim, K., Miyagawa, K., Wang, L., Cao, A., Sa, S., Jiang, X., Stockstill, R. W., Nicolls, M. R., Zamanian, R. T., Bland, R. D., Rabinovitch, M. Am J Respir Crit Care Med. 2015; 191 (11): 1273-1286
• BMPR2 Preserves Mitochondrial Function and DNA during Reoxygenation to Promote Endothelial Cell Survival and Reverse Pulmonary Hypertension
  Diebold, I., Hennigs, J. K., Miyagawa, K., Li, C. G., Nickel, N. P., Kaschwich, M., Cao, A., Wang, L., Reddy, S., Chen, P., Nakahira, K., Alcazar, M. A., Hopper, R. K., Ji, L., Feldman, B. J., Rabinovitch, M. Cell Metabolism.  2015; 21 (4): 596-608
• Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension
  Rabinovitch, M., Guignabert, C., Humbert, M., Nicolls, M. R. Circ Res.  2014; 115 (1): 165-175
• Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension
  Sawada, H., Saito, T., Nickel, N. P., Alastalo, T., Glotzbach, J. P., Chan, R., Haghighat, L., Fuchs, G., Januszyk, M., Cao, A., Lai, Y., Perez, V. D., Kim, Y., Wang, L., Chen, P., Spiekerkoetter, E., Mitani, Y., Gurtner, G. C., Sarnow, P., Rabinovitch, M. J Exp Med. 2014; 211 (2): 263-280
• FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.
  Spiekerkoetter, E., Tian, X., Cai, J., Hopper, R. K., Sudheendra, D., Li, C. G., El-Bizri, N., Sawada, H., Haghighat, R., Chan, R., Haghighat, L., de Jesus Perez, V., Wang, L., Reddy, S., Zhao, M., Bernstein, D., Solow-Cordero, D. E., Beachy, P. A., Wandless, T. J., ten Dijke, P., Rabinovitch, M.   J Clin Invest. 2013; 123 (8): 3600-3613
• Combining induced pluripotent stem cell with next generation sequencing technology to gain new insights into pathobiology and treatment of pulmonary arterial hypertension. Rabinovitch, M. Pulmonary Criculation. 2013; 3 (1): 153-155
• Loss of adenomatous poliposis coli-a3 integrin interaction promotes endothelial apoptosis in mice and humans.
  de Jesus Perez, V. A., Yuan, K., Orcholski, M. E., Sawada, H., Zhao, M., Li, C. G., Tojais, N. F., Nickel, N., Rajagopalan, V., Spiekerkoetter, E., Wang, L., Dutta, R., Bernstein, D., Rabinovitch, M. Circ Res. 2012; 111 (12): 1551-1564
• Neutrophil Elastase Is Produced by Pulmonary Artery Smooth Muscle Cells and Is Linked to Neointimal Lesions
  Kim, Y., Haghighat, L., Spiekerkoetter, E., Sawada, H., Alvira, C. M., Wang, L., Acharya, S., Rodriguez-Colon, G., Orton, A., Zhao, M., Rabinovitch, M. Am J Pathol. 2011; 179 (3): 1560-1572
• Disruption of PPAR gamma/beta-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
  Alastalo, T., Li, M., Perez, V. D., Pham, D., Sawada, H., Wang, J. K., Koskenvuo, M., Wang, L., Freeman, B. A., Chang, H. Y., Rabinovitch, M.  J Clin Invest.  2011; 121 (9): 3735-3746
• Inhibition of Transforming Growth Factor beta Worsens Elastin Degradation in a Murine Model of Kawasaki Disease Alvira, C. M., Guignabert, C., Kim, Y., Chen, C., Wang, L., Duong, T. T., Yeung, R. S., Li, D. Y., Rabinovitch, M. Am J Pathol.  2011; 178 (3): 1210-1220
• BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways
  Perez, V. A., Ali, Z., Alastalo, T., Ikeno, F., Sawada, H., Lai, Y., Kleisli, T., Spiekerkoetter, E., Qu, X., Rubinos, L. H., Ashley, E., Amieva, M., Dedhar, S., Rabinovitch, M. J Cell Biol.  2011; 192 (1): 171-188
  This article is featured in biobytes podcast, http://jcb.rupress.org/content/192/1/171/suppl/DC2
• Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization Guignabert, C., Alvira, C. M., Alastalo, T., Sawada, H., Hansmann, G., Zhao, M., Wang, L., El-Bizri, N., Rabinovitch, M..  Am J Physiol Lung Cell Mol Physiol. 2009; 297 (6): L1082-L1090
• S100A4 and Bone Morphogenetic Protein-2 Codependently Induce Vascular Smooth Muscle Cell Migration via Phospho-Extracellular Signal-Regulated Kinase and Chloride Intracellular Channel 4
  Spiekerkoetter, E., Guignabert, C., Perez, V. D., Alastalo, T., Powers, J. M., Wang, L., Lawrie, A., Ambartsumian, N., Schmidt, A., Berryman, M., Ashley, R. H., Rabinovitch, M. Circ Res. 2009; 105 (7): 639-U37
• Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways
  Perez, V. A., Alastalo, T., Wu, J. C., Axelrod, J. D., Cooke, J. P., Amieva, M., Rabinovitch, M. J Cell Biol.  2009; 184 (1): 83-99
• SM22 alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis
  El-Bizri, N., Guignabert, C., Wang, L., Cheng, A., Stankunas, K., Chang, C., Mishina, Y., Rabinovitch, M. Development . 2008; 135 (17): 2981-2991
• Marlene Rabinovitch, MD — All Publications